Relevance of pharmacokinetics and pharmacodynamics

This ex post facto study investigated the relationship of social support from two workplace sources, unit managers and registered nurse (RNs) coworkers, to work-related stress among staff nurses. Sample participants included 51 full-time RNs from a variety of clinical specialties in one nursing organization. The three theoretical components--affect, affirmation, and aid--were measured by the Norbeck Social Support Questionnaire. The Nursing Stress Scale was used to quantify the levels of perceived work-related stress. Statistically significant negative correlations were found between affect from unit managers (r = -299; P = 0.15) and aid from coworkers (r = -.294; P = .036) on levels of perceived work-related stress. Additionally, the increased age of the subjects (r = -.342; P = .007), years of nursing experience (r = -252; P = .037), and length of employment (r = -329; P = .009) had a negative relationship with work stress. The results of this research demonstrated that two components of social support--affect (emotional support) from unit managers and aid (services, information, materials) from coworkers--were linked to lower stress scores in this sample of staff nurses.     

A non-specific lipid transfer protein from Arabidopsis is a cell wall protein

Lipid transfer proteins (LTPs), mediate the transfer of phospholipids between membranes in vitro. However, the in vivo function of LTPs is not known. To determine the precise location of a non-specific LTP from Arabidopsis, a cDNA clone was used to produce an Arabidopsis LTP:protein A fusion. Antibodies raised against the fusion were used to localize the Arabidopsis LTP by immunoelectron microscopy. LTP was found to be located in the cell wall, mainly in epidermal cells. This location appears to be inconsistent with the proposed role of the protein in intracellular lipid transfer.     

An outbreak of hepatitis A among homosexual men in Melbourne

OBJECTIVE: To describe an outbreak of hepatitis A virus (HAV) infection that occurred in Melbourne in 1991. DESIGN: (i) We reviewed Health Department Victoria surveillance data from 1989 to 1991 (primary surveillance) and identified all notified cases of HAV infection with an onset of illness between 1 January and 31 December 1991 (secondary surveillance data). (ii) We studied HAV seroprevalence in Melbourne among homosexual men attending gay venues. RESULTS: (i) In the two years 1989-1990 there were only 55 notifications of HAV infection to Health Department Victoria, with a male:female ratio of 1.2:1. Of the 495 notifications for 1991, 407 (82%) were male, of whom 210 (52%) were known to be homosexual. Many reported sexual and social contact at Melbourne's gay venues and with the Sydney gay community. (ii) Of men attending gay venues, 27% had serological evidence of past infection with HAV, compared with 45.8% in a 1981 Melbourne study. CONCLUSION: The outbreak of HAV infection in Victoria largely affected homosexual males in their sexually active years. Contact with the Sydney gay community was commonly reported.     

The influence of trigger configurations and laminate lay-up on the failure mode of composite crush cylinders

In this paper the results are presented of a test program on the energy absorption of composite cylinders loaded in compression. The influence of the laminate lay-up and of the trigger configuration were determined. Two different failure modes for the different laminates and triggers were observed: a splaying mode and a fragmentation mode. The splaying mode is more efficient in absorbing energy. The failure mode did not change during the crushing process.     

Cable insulation density profile determined from ultrasonicvelocity measurements

Density results obtained on the same cable sample with a column and from ultrasonic measurements are reported. A calibration curve relating ultrasonic velocity and cable insulation density is given for PE and crosslinked PE (XLPE) cables. The limits and advantages of deducing density profiles of cable insulation using a focused, ultrasound beam rather than the more time-consuming column measurements are discussed     

Magnetic resonance imaging study on the results of surgery for cervical compression myelopathy

The morphologic changes and signal intensity of the spinal cord on preoperative magnetic resonance images were correlated with postoperative outcomes in 74 patients undergoing decompressive cervical surgery for compressive myelopathy. The transverse area of the spinal cord on T1-weighted images at the level of maximum compression was closely correlated with the severity of myelopathy, duration of disease, and recovery rate as determined by the Japanese Orthopaedic Association score. In patients with ossification of the posterior longitudinal ligament or cervical spondylotic myelopathy, the increased intramedullary T2-weighted magnetic resonance imaging signal at the site of maximal cord compression and duration of disease significantly influenced the rate of recovery. A multiple regression equation was then developed with these three variables to predict surgical outcomes.