Thiamine pyrophosphatase activity in the Golgi apparatus of calcitonin-treated osteoclasts.

The thiamine pyrophosphatase (TPPase) activity described by Novikoff and Goldfisher was examined in osteoclasts affected by calcitonin in order to elucidate whether the morphological and functional changes of the osteoclasts have an influence over the secretion function of their Golgi apparatus. The Golgi apparatus of osteoclasts of which the ruffled border had disappeared and bone resorption discontinued as the result of treatment with calcitonin showed a slight TPPase activity. The reaction products of the enzyme in these inactive osteoclasts were distinctly fewer than that of control osteoclasts, which were not affected by calcitonin. From these results, it is suggested that there may be a connection between the morphological and functional changes of osteoclasts and the secretion function of the Golgi apparatus.     

Electrical and optical feedback in an InGaAs/InP light-amplifyingoptical switch (LAOS)

A circuit model for optical and electrical feedback has been developed to investigate the cause of negative differential resistance (NDR) switching in a series connected heterojunction phototransistor (HPT) light-emitting diode (LED) device. The model considers optical feedback from the light generated in the LED, electrical feedback from the holes thermally emitted over the LED cladding layer, nonlinear gain of the HPT, the Early effect, and leakage resistance. The analysis shows that either electrical or optical feedback can be the dominant cause for the NDR, depending upon their relative strengths. The NDR observed in the devices was caused primarily by electrical feedback since the optical feedback is weak. For low input power, avalanche breakdown appears to initiate the NDR in the devices although avalanching alone cannot cause NDR     

A Tuning Circuit with Two Half-Wave Distributed Junctions for All-NbN SIS Mixers

A novel broadband tuning circuit composed of two low-current-density half-wave NbN/MgO/NbN tunnel junctions connected by a half-wave NbN/MgO/NbN microstrip line has been successfully tested in a quasi-optical mixer at frequencies above 700 GHz. The circuit had a designed center frequency of 870 GHz, was integrated in a center-fed twin-slot antenna, and was fed via a quarter-wave impedance transformer. Heterodyne measurments showed double-side-band receiver noise temperatures equivalent to 6-9 quanta from 675 to 810 GHz for a mixer with a current density of 6.7 kA/cm². The RF bandwidth was broader than that of a conventional mixer using a full-wave junction with the same current density.     

Improved Poisson intensity estimation: denoising application using Poisson data

Recently, Timmermann and Nowak developed algorithms for estimating the means of independent Poisson random variables. The algorithms are based on a multiscale model where certain random variables are assumed to obey a beta-mixture density function. Timmermann and Nowak simplify the density estimation problem by assuming the beta parameters are known and only one mixture parameter is unknown. They use the observed data and the method of moments to estimate the unknown mixture parameter. Taking a different approach, we generate training data from the observed data and compute maximum likelihood estimates of all of the beta-mixture parameters. To assess the improved performance obtained by the proposed modification, we consider a denoising application using Poisson data.     

Protocol design for scalable and reliable group rekeying

We present the design and specification of a protocol for scalable and reliable group rekeying together with performance evaluation results. The protocol is based upon the use of key trees for secure groups and periodic batch rekeying. At the beginning of each rekey interval, the key server sends a rekey message to all users consisting of encrypted new keys (encryptions, in short) carried in a sequence of packets. We present a scheme for identifying keys, encryptions, and users, and a key assignment algorithm that ensures that the encryptions needed by a user are in the same packet. Our protocol provides reliable delivery of new keys to all users eventually. It also attempts to deliver new keys to all users with a high probability by the end of the rekey interval. For each rekey message, the protocol runs in two steps: a multicast step followed by a unicast step. Proactive forward error correction (FEC) multicast is used to reduce delivery latency. Our experiments show that a small FEC block size can be used to reduce encoding time at the server without increasing server bandwidth overhead. Early transition to unicast, after at most two multicast rounds, further reduces the worst-case delivery latency as well as user bandwidth requirement. The key server adaptively adjusts the proactivity factor based upon past feedback information; our experiments show that the number of NACKs after a multicast round can be effectively controlled around a target number. Throughout the protocol design, we strive to minimize processing and bandwidth requirements for both the key server and users.     

Service Load Effective Compression Flange Width in Fiber Reinforced Polymer Deck Systems Acting Compositely with Steel Stringers

This paper reports on the field study of a steel stringer-fiber reinforced polymer (FRP) deck composite bridge in Pennsylvania. The objective of the study is to assess the effective compression flange width in the FRP deck and floor systems when they act compositely with underlying steel girders at service conditions. The research results reported herein support the notion of employing a design approach, for both interior and exterior girders of a composite floor system, that is philosophically consistent with current practice related to steel girders acting compositely with concrete decking. It appears from the results presented herein that FRP decks and floors acting compositely with underlying steel girders exhibit an effective width that is close to the actual girder spacing for interior beams, and approximately one-half this value for exterior beams.     

High‐Tg Carbazole Derivatives as Blue‐Emitting Hole‐Transporting Materials for Electroluminescent Devices

A series of dicarbazolyl derivatives bridged by various aromatic spacers and decorated with peripheral diarylamines were synthesized using Ullmann and Pd‐catalyzed C–N coupling procedures. These derivatives emit blue light in solution. In general, they possess high glass‐transition temperatures (T_g > 125 °C) which vary with the bridging segment and methyl substitution on the peripheral amine. Double‐layer organic light‐emitting devices were successfully fabricated using these molecules as hole‐transporting and emitting materials. Devices of the configuration ITO/HTL/TPBI/Mg:Ag (ITO: indium tin oxide; HTL: hole‐transporting layer; TPBI: 1,3,5‐tris(N‐phenylbenzimidazol‐2‐yl)benzene) display blue emission from the HTL layer. The EL spectra of these devices appear slightly distorted due to the exciplex formation at the interfaces. However, for the devices of the configuration ITO/HTL/Alq₃/Mg:Ag (Alq₃ = tris(8‐hydroxyquinoline)aluminum) a bright green light from the Alq₃ layer was observed. This clearly demonstrates the facile hole‐transporting property of the materials described here.     

Cramer-Rao bounds for parametric shape estimation in inverse problems

We address the problem of computing fundamental performance bounds for estimation of object boundaries from noisy measurements in inverse problems, when the boundaries are parameterized by a finite number of unknown variables. Our model applies to multiple unknown objects, each with its own unknown gray level, or color, and boundary parameterization, on an arbitrary known background. While such fundamental bounds on the performance of shape estimation algorithms can in principle be derived from the Cramer-Rao lower bounds, very few results have been reported due to the difficulty of computing the derivatives of a functional with respect to shape deformation. We provide a general formula for computing Cramer-Rao lower bounds in inverse problems where the observations are related to the object by a general linear transform, followed by a possibly nonlinear and noisy measurement system. As an illustration, we derive explicit formulas for computed tomography, Fourier imaging, and deconvolution problems. The bounds reveal that highly accurate parametric reconstructions are possible in these examples, using severely limited and noisy data.