Chemical Factors Affecting Preparation of Carboxymethyl Starch

Preparation of carboxymethyl starch using chloroacetic acid and sodium hydroxide was investigated under different conditions. The carboxymethylation reaction was studied with respect to the degree of substitution (D. S.) of the carboxymethyl starch and the reaction efficiency (R. E.) of carboxymethylation variables studied included concentration of reactants and liquor ratio as well as reaction time and temperature. D. S. and R. E. were greatly enhanced by decreasing the liquor ratio. D. S. and R. E. increased also by increasing the reaction time. On the other hand, increasing the monochloroacetic acid concentration was accompanied by enhancement in the D. S. and decrement in the R. E., while both the D. S. and R. E. exhibited maximum values at 4N sodium hydroxide. The combined effect of increasing both monochloroacetic acid and sodium hydroxide concentrations was to bring about increased D. S. and decreased R. E. irrespective of the reaction temperature. Of particular interest were the results obtained at 100°C for 1 h; carboxymethyl starch of D. S. 0.436 with R. E. of ca. 79% could be achieved using solid reactants/liquor ratio of 1: 1.     

A Novel Sprague-Dawley Rat Model Presents Improved NASH/NAFLD Symptoms with PEG Coated Vitexin Liposomes

Chronic liver disease (CLD) is a global threat to the human population, with manifestations resulting from alcohol-related liver disease (ALD) and non-alcohol fatty liver disease (NAFLD). NAFLD, if not treated, may progress to non-alcoholic steatohepatitis (NASH). Furthermore, inflammation leads to liver fibrosis, cirrhosis, and hepatocellular carcinoma. Vitexin, a natural flavonoid, has been recently reported for inhibiting NAFLD. It is a lipogenesis inhibitor and activates lipolysis and fatty acid oxidation. In addition, owing to its antioxidant properties, it appeared as a hepatoprotective candidate. However, it exhibits low bioavailability and low efficacy due to its hydrophobic nature. A novel rat model for liver cirrhosis was developed by CCL4/Urethane co-administration. Vitexin encapsulated liposomes were synthesized by the ‘thin-film hydration’ method. Polyethylene glycol (PEG) was coated on liposomes to enhance stability and stealth effect. The diseased rats were then treated with vitexin and PEGylated vitexin liposomes, administered intravenously and orally. Results ascertained the liposomal encapsulation of vitexin and subsequent PEG coating to be a substantial strategy for treating liver cirrhosis through oral drug delivery.     

Design modeling of lithium-ion battery performance

A computer design modeling technique has been developed for lithium-ion batteries to assist in setting goals for cell components, assessing materials requirements, and evaluating thermal management strategies. In this study, the input data for the model included design criteria from Quallion, LLC for Gen-2 18650 cells, which were used to test the accuracy of the dimensional modeling. Performance measurements on these cells were done at the electrochemical analysis and diagnostics laboratory (EADL) at Argonne National Laboratory. The impedance and capacity related criteria were calculated from the EADL measurements. Five batteries were designed for which the number of windings around the cell core was increased for each succeeding battery to study the effect of this variable upon the dimensions, weight, and performance of the batteries. The lumped-parameter battery model values were calculated for these batteries from the laboratory results, with adjustments for the current collection resistance calculated for the individual batteries.     

Determination of atmospheric turbidity in Bangladesh

Atmospheric turbidity parameters have been determined following Angstrom's method at three locations in Bangladesh namely, Dhaka city (23.7°N) and two rural locations, Haripur (26.03°N) and Sripur (24.11°N). The parameters were obtained from direct solar radiation data for specific spectral regions and for the whole spectrum as measured using a normal incidence pyrheliometer provided with cut-off glass filters. A considerable variation of Angstrom's turbidity parameters for Dhaka over the year was observed with a maximum value in March. The value for Sripur for the month of March was somewhat lower and the value for Haripur for the month of April was not much different from that of Dhaka. Linke turbidity factor T_L was also determined using the new value of solar constant 1367 W/m² for all three locations.     

Numerical analysis of natural convection heat transfer in a horizontal annulus partially filled with a fluid-saturated porous substrate

The current study centers around a numerical investigation of natural convection heat transfer within a two-dimensional, horizontal annulus that is partially filled with a fluid-saturated porous medium. In addition, the porous sleeve is considered to be press fitted to the inner surface of the outer cylinder. Both cylinders are maintained at constant and uniform temperatures with the inner cylinder being subjected to a relatively higher temperature than the outer one. Moreover, the Forchheimer and Brinkman effects are taken into consideration when simulating the fluid motion inside the porous sleeve. Furthermore, the local thermal equilibrium condition is assumed to be applicable for the current investigation. The working fluid is air while copper is used to represent the solid phase. The porosity is considered to be uniform and constant with ε = 0.9. The main objective of this study is to examine the effect of the porous sleeve on the buoyancy induced flow motion under steady-state condition. Such an effect is studied using the following dimensionless parameters: Pr = 0.05–50, Ra = 10²–10⁶ and Da = 10^?4–10^?6. Also, the study highlights the effect of the dimensionless porous sleeve thickness (b) and thermal conductivity ratio (k_s/k_f) in the range between 1.1–1.9 and 1–150, respectively.     

Automated brain tumor segmentation on multi-modal MR image using SegNet

Computational Visual Media - The potential of improving disease detection and treatment planning comes with accurate and fully automatic algorithms for brain tumor segmentation. Glioma, a type of...     

Three‐dimensional computational comparison of mini pinned heat sinks using different nanofluids: Part one—the hydraulic‐thermal characteristics

The hydraulic‐thermal characteristics of 3D pinned heat sink designs have been numerically compared as the first part of a three‐part investigation. Five different pin geometries (circular, square, triangular, strip, and elliptic pins) and an unpinned heat sink with three types of nanofluids (Al₂O₃–H₂O, SiO₂–H₂O, and CuO–H₂O) are considered for laminar forced convection. The range of Reynolds number is from 100 to 1000, and volume fractions vary between 0% and 5%. The finite volume method is employed to solve the Navier–Stokes and energy equations by employing a SIMPLE algorithm for a computational solution. Three parameters are presented—the Nusselt number, the bottom temperature, and the hydrothermal performance of the heat sink with pressure drop data. The findings indicated that the overall hydrothermal performance of elliptic‐pinned (EP) heat sinks produces the most substantial value of 3.10 for pure water. For different nanofluids, the SiO₂–water nanofluids with EPs have the most significant hydrothermal performance. Also, this factor is enhanced with an increase in nanofluid concentration up to nearly 3.34 for 5% of SiO₂–water. Consequently, applying the elliptic‐pinned heat sinks is recommended with pure water for considering an increase in the pressure drop, with 5% of SiO₂–water nanofluids, regardless of an enlargement of pressure drop for heat‐dissipation applications.     

Steerable Microinvasive Probes for Localized Drug Delivery to Deep Tissue

Enhanced understanding of neuropathologies has created a need for more advanced tools. Current neural implants result in extensive glial scarring and are not able to highly localize drug delivery due to their size. Smaller implants reduce surgical trauma and improve spatial resolution, but such a reduction requires improvements in device design to enable accurate and chronic implantation in subcortical structures. Flexible needle steering techniques offer improved control over implant placement, but often require complex closed‐loop control for accurate implantation. This study reports the development of steerable microinvasive neural implants (S‐MINIs) constructed from borosilicate capillaries (OD = 60 µm, ID = 20 µm) that do not require closed‐loop guidance or guide tubes. S‐MINIs reduce glial scarring 3.5‐fold compared to prior implants. Bevel steered needles are utilized for open‐loop targeting of deep‐brain structures. This study demonstrates a sinusoidal relationship between implant bevel angle and the trajectory radius of curvature both in vitro and ex vivo. This relationship allows for bevel‐tipped capillaries to be steered to a target with an average error of 0.23 mm ± 0.19 without closed‐loop control. Polished microcapillaries present a new microinvasive tool for chronic, predictable targeting of pathophysiological structures without the need for closed‐loop feedback and complex imaging.     

Formation and Phase Behavior of Winsor Type III <Emphasis Type="Italic">Jatropha curcas</Emphasis>-Based Microemulsion Systems

The formation and phase behavior of Jatropha curcas-based microemulsion systems, which could potentially be used in enhanced oil recovery applications, has been investigated. Winsor type III microemulsions were obtained by adding n-octane to Winsor type I microemulsion systems prepared using various concentrations of alkyl polyglucoside (APG). To optimize the formulation of type III microemulsion systems, five different types of co-surfactants, i.e. normal butyl alcohol (NBA), isobutyl alcohol, isopropyl alcohol, fatty acid alcohol C8 (FAC8) and fatty acid alcohol C8/C10 (FAC8/C10) were used. The microemulsion phase behavior was determined along with particle size distributions by dynamic light scattering measurements. Results show that the optimum Winston type III system can be achieved by mixing 3 wt% of NBA, 1 wt% APG and 3 wt% NaCl. At the optimum formulation, the IFT reached a minimum value (0.016 mN/m) and formed very small emulsion droplets with a narrow particle size distribution.