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81.
Heterozygous mutations in the gene for the Kit transmembrane receptor have been identified recently in human piebaldism and mouse "dominant spotting." Interestingly, all of the 14 known missense mutations that cause depigmentation in these species map to the tyrosine kinase domain of the receptor, whereas none have involved the extracellular ligand-binding domain. In an attempt to detect these uncommon mutations, we screened the nine exons encoding the extracellular portion of Kit for single-strand conformation polymorphisms (SSCP) in eight piebald subjects previously reported to be negative for kinase mutations. Four of these eight kindreds proved to carry novel mutations. The first mutation, found in two apparently unrelated probands with mild piebaldism and English ancestry, substitutes an arginine for a highly conserved cysteine at codon 136. This substitution disrupts a putative disulfide bond required for formation of the second Ig-like (D2) loop of the Kit ligand-binding domain. The second mutation, detected in a piebald kindred characterized by unusually limited depigmentation, substitutes a threonine for an alanine at codon 178, a site just proximal to conserved cysteines at codons 183 and 186. The third mutation, occurring in a kindred with more extensive depigmentation, is a novel four-base insertion in exon 2 that results in a proximal frameshift and premature termination. The data strongly suggest that piebaldism can result from missense mutations in the Kit ligand-binding domain, although the resulting phenotype may be milder than that observed for null or kinase mutations. The apparent clustering of these uncommon mutations at or near the conserved cysteines for the D2 Ig-like loop further suggests a critical role for this region in Kit receptor function. 相似文献
82.
Sul Gee Park Ho Cheol Jeong Jeong Won Kim Dong-Hwan Hwang Sang Jeong Lee 《International Journal of Control, Automation and Systems》2011,9(2):276-284
This paper proposes a magnetic compass fault detection method for GPS/INS/Magnetic compass integrated navigation systems.
The fault is assumed to be caused by the hard iron and soft iron effect and modeled as an abrupt change in the magnetic compass
output. In order to detect the fault, a test statistic related with only azimuth error measurement is determined. When a fault
is detected, the GPS/INS/Magnetic compass integrated navigation system is changed into a GPS/INS integrated navigation system
mode. In order to show the validity of the proposed method, computer simulation and van testing are carried out. The simulation
and van test results show that the proposed navigation system gives more accurate outputs than the GPS/INS/Magnetic compass
without the proposed method. 相似文献
83.
Dong-Pyoung Sheen Tae-geun Son Dae-Kwang Myung Cheolho Ryu Sang Hun Lee Kunwoo Lee Tae Jung Yeo 《Computer aided design》2010,42(8):720-730
A simplified geometric model with lower dimensionality, such as a mid-surface model, is often preferred over a detailed solid model for the analysis process, if the analysis results are not seriously impacted. In order to derive a mid-surface model from a thin-walled solid model, in this paper, we propose a novel approach called the solid deflation method. In this method, a solid model is assumed to be created by using air to inflate a shell that comprises the surface of the solid model. First, the model is simplified by the removal of any detailed features whose absence would not alter its overall shape. Next, the solid model itself can be converted into a degenerate solid model with zero thickness. Finally, a surface model is generated by splitting large faces paired in the thinned solid model, selecting one face per pair for creating a sheet model, and sewing the selected faces. Using this method, a more practical and usable mid-surface model can be very efficiently generated from a solid model because it can circumvent not only the tedious trimming and extension processes of the medial axis transformation method but also the time-consuming patch joining process of the mid-surface abstraction approach. 相似文献
84.
In recent years, Radio Frequency Identification (RFID) industries have taken a great interest in utilizing the benefits of RFID for supply chain management, inventory control and various other applications. This paper proposed an adaptive load balancing technique for RFID middleware systems to meet the demands of scalability and heterogeneity. First, we explored five basic load balancing policies, namely, information policy, job selection policy, transfer policy, initiation policy and location policy. Eighteen load balancing schemes were then proposed for RFID middleware systems that were combinations of various types of the five basic load balancing policies. Our empirical study suggested that these load balancing strategies performed differently under different workload statuses. Finally, an adaptive load balancing strategy was proposed. The load balancing schemes and the proposed adaptive load balancing strategy have been implemented in the RFID Middleware Load Management System (RM‐LMS). Copyright © 2010 John Wiley & Sons, Ltd. 相似文献
85.
Yong‐Kyu Jang Seong Jun Lee Jae Young Lee Yi Li Jae Hoon Hwang Sang Woo Kim Chang Woo Shim Ju Yeon Seo Nam Jin Kim Yi Joon Ahn Nam Hee Kim Seon Hong Ahn Seong Ryong Lee Dae Hee Park Chi Woo Kim 《Journal of the Society for Information Display》2011,19(3):253-257
Abstract— A novel pixel design for vertical‐alignment LCDs with superior transmittance has been developed. The new liquid‐crystal mode, refered to as the hole‐induced vertical‐alignment mode (Hi‐VA), uses a via hole of an organic layer on a TFT substrate to achieve multi‐domain alignment. Compared to the conventional design, the Hi‐VA mode has a transmittance of up to 135% with a contrast ratio of 2000:1. Moreover, the new structure is free from ITO patterning or protrusion on the color‐filter side, which makes the fabrication process simple and low cost. 相似文献
86.
The human shoulder complex is perhaps the most complicated joint in the human body being comprised of a set of three bones, muscles, tendons, and ligaments. Despite this anatomical complexity, computer graphics models for motion capture most often represent this joint as a simple ball and socket. In this paper, we present a method to determine a shoulder skeletal model that, when combined with standard skinning algorithms, generates a more visually pleasing animation that is a closer approximation to the actual skin deformations of the human body. We use a data‐driven approach and collect ground truth skin deformation data with an optical motion capture system with a large number of markers (200 markers on the shoulder complex alone). We cluster these markers during movement sequences and discover that adding one extra joint around the shoulder improves the resulting animation qualitatively and quantitatively yielding a marker set of approximately 70 markers for the complete skeleton. We demonstrate the effectiveness of our skeletal model by comparing it with ground truth data as well as with recorded video. We show its practicality by integrating it with the conventional rendering/animation pipeline. 相似文献
87.
This paper considers ‘two-stage’ call centers where some incoming calls are completed by first service while others require an additional second service. Although this type of call center is not uncommon, it has not been dealt with, if any, in the call center literature. In this paper, we introduce the concept of the ‘two-stage’ call center and discuss its features. Furthermore, we develop an effective outsourcing strategy in ‘two-stage’ call centers. To this end, we model ‘two-stage’ service system and propose several call routing structures. The structures are compared through numerical test and conventional queueing theories form the theoretical basis of our study. 相似文献
88.
Developing future weapons systems has become increasingly complicated and costly. The armed forces of major nations use modeling and simulation techniques for new weapons systems from the conceptual stage to design, production, deployment and training stages to shorten the development cycle and guarantee their effectiveness. Failure in the development cycle carries too much loss in time and money. Therefore, computer-based modeling and simulation techniques are applied from the conceptual stage to gauge the efficacy of new weapons systems. The objective of this study is to develop a modeling and simulation methodology for small scale engagement using the DEVS formalism. The entities required for modeling and simulation are divided into three categories: combat, logical, and environmental entities. Combat entities represent the military hardware or combatants; logical entities represent the judgment and decision entities for the interaction between various entities; and environmental entities emulate the constituents of real combat environment. The combat entities are further modeled into Shell and Core Parts to maximize their reusability under various combat scenarios. The proposed framework is verified using a one-on-one combat engagement simulation (written in C++) between two submarines. 相似文献
89.
Consumer perceptions on web advertisements and motivation factors to purchase in the online shopping
The principal objective of this study was to investigate the mediating and moderating effects of product involvement and trust toward websites in relation to the effects of the attributes of web advertisements on customers’ purchase intentions. We collected data consisting of a total of 264 responses from individuals with previous experience with purchasing products from online shopping mall sites, and utilized the PLS (partial least squares) method to analyze the collected data. 相似文献
90.
本文主要介绍了TDD—OFDM技术原理以及在无线图像传输中的优点,在消防通信中的应用、组网和应用模式、特点。通过现场不同的组网方式完成现场音视频、数据等传输,为灾害事故现场视频图像传输提供了一种有效的解决途径,提高了公安消防部队应对各种突发性灾害事件的能力和指挥决策能力。 相似文献