Simultaneous radioimmunoassay of thyroid hormones in unextracted serum

Weekly atmospheric sampling in the Pocatello, Idaho, area and skin testing with a standard inland smut mixture of the smuts of common cereal grains and grasses have shown that smut is a prominent antigen and, used rationally in a mixture of related antigens, is useful in all seasons in the treatment of allergies. The history, agricultural aspects and medical significance of smuts are discussed.     

Collecting and processing records from the ultracentrifuge in "real-time" using an on-line computer

An analytical system consisting of an analytical cantrifuge coupled 'on-line' to a computer was assembled and tested. Collection of records from up to 9 solutions was achieved through programmes which sum readings to reduce noise as well as controlling the positioning of the scanner. With this system it was found that the limit on accuracy for molecular weights at concentrations less than 0.01 g cm-3 was +/- 3% estimated from sedimentation equilibrium experiments. The same system was used to collect records for similar concentrations from velocity experiments by employing a scanning schlieren. In this case the accuracy in estimating sedimentation coefficients was similar to those found when measuring photographs. Since the collection yields detailed information about the shape of the sedimenting boundary, the centroids of the boundary were routinely computed by second moment analysis rather than relying on the position of the maximum of the schlieren peak. In the same analysis estimates of diffusion coefficients were made routinely by calculating corrected height/area ratios for each scan. These calculations were made during the real-time of the experiment, so making available molecular parameters rather than records which must be evaluated some time after stopping the experiment.     

Post-secretory deiodination of iodothyronines released from normal human thyroid cells in vitro

The Salmonella strains described in this paper were isolated from clinical and environmental sources in Togo (West Africa). All strains belong to subgenus I of the genus Salmonella. 1. Salmonella kodjovi 47:c:-, Supplement No. XVII (1974), isolated from stool specimen 2. Salmonella dadzie 51:1, v:e, n, x, Supplement No. XVII (1974), isolated from stool specimen 3. Salmonella mono 4, 12:1, w:1, 5, Supplement No. XVII (1975), isolated from pig droppings 4. Salmonella chincol var. s-, monophas. 6, 8:g, m:-, Supplement No. XVIII (1975), isolated from lizard intestines 5. Salmonella chicago var. i+, 28:r, i:1,5, Supplement No. XVIII (1975), isolated from stool specimen 6. Salmonella havana var. s+, 36+, 13,23:f,g,s:-, Supplement No. XVIII (1974), isolated from stool specimen 7. Salmonella elisabethville var. 15+, 3,15:r:1,7, isolated from lizard intestines.     

Detection of sight-threatening diabetic eye disease

Blindness due to diabetes mellitus is potentially preventable in the majority of patient. Early detection of sight-threatening changes is associated with a better outcome, indicating the need to screen for retinopathy. At least 50% of diabetic patients do not attend a hospital, so that diabetologists and ophthalmologists are unable to screen the diabetic population comprehensively. Although in theory all patients has access to general practitioners, these may lack training or confidence to screen for retinopathy. Hospital based or community optometrists using direct ophthalmoscopy or slit lamps and technicians performing fundus photography are alternatives which may be more effective. Further studies are required to examine the effectiveness of optometry screening. Initial studies using fundus photography raised concerns about the sensitivity of the technique, but these have been partially addressed by improvements in methodology and technology. As well as technicological effectiveness, factors affecting patient uptake of screening services still need to be addressed.     

Assessment of regional left ventricular long-axis motion with MR velocity mapping in healthy subjects

We present a case of trichothiodystrophy associated with a hypereosinophilic syndrome. This case had been followed for 30 years. Trichothiodystrophy was characterized by lamellar ichthyosis, hair and nail dystrophies, kyphoscoliosis, congenital luxation of the hip. The hypereosinophilic syndrome was characterized by an itching urticaria-like eruption. Although the patient's general condition had remaining stable for 30 years, during the last year it worsened and the patient suddenly died. The authors discuss about the significance of this association.