Prolonged rewarding stimulation of the rat medial forebrain bundle: Neurochemical and behavioral consequences.

Extracellular dopamine levels were measured in the rat nucleus accumbens by means of in vivo microdialysis. Delivery of rewarding medial forebrain bundle stimulation at a low rate (5 trains/min) produced a sustained elevation of dopamine levels, regardless of whether train onset was predictable. When the rate of train delivery was increased to 40 trains/min, dopamine levels rose rapidly during the first 40 min but then declined toward the baseline range. The rewarding impact of the stimulation was reduced following prior delivery of stimulation at the high, but not the low, rate. These results support the idea that dopamine tone plays an enabling role in brain stimulation reward and is elevated similarly by predictable and unpredictable stimulation. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Modeling and querying moving objects in networks

Moving objects databases have become an important research issue in recent years. For modeling and querying moving objects, there exists a comprehensive framework of abstract data types to describe objects moving freely in the 2D plane, providing data types such as moving point or moving region. However, in many applications people or vehicles move along transportation networks. It makes a lot of sense to model the network explicitly and to describe movements relative to the network rather than unconstrained space, because then it is much easier to formulate in queries relationships between moving objects and the network. Moreover, such models can be better supported in indexing and query processing. In this paper, we extend the ADT approach by modeling networks explicitly and providing data types for static and moving network positions and regions. In a highway network, example entities corresponding to these data types are motels, construction areas, cars, and traffic jams. The network model is not too simplistic; it allows one to distinguish simple roads and divided highways and to describe the possible traversals of junctions precisely. The new types and operations are integrated seamlessly into the ADT framework to achieve a relatively simple, consistent and powerful overall model and query language for constrained and unconstrained movement.     

Adaptive channel allocation for wireless PCN

In cellular networks, forced call terminations due to handoff call blocking are generally more objectionable than new call blocking. In order to maintain an acceptable call dropping probability rate, we propose, in this paper, two new guard channel schemes: an adaptive one – New Adaptive Channel Reservation (NACR) – and a dynamic one – Predictive Reservation Policy (PRP). In NACR, for a given period of time, a given number of channels is guarded in each cell for handoff traffic. In PRP, the number of reserved channels depends on the actual number of calls in progress in the neighboring cells. An approximate analytical model of NACR is presented. A Tabu search method has been implemented in order to optimize the Grade of Service. Discrete event simulations of PRP and NACR were run. The effectiveness of the proposed methods is emphasized on a complex configuration.     

Extracellular matrix survival signals transduced by focal adhesion kinase suppress p53-mediated apoptosis

In many malignant cells, both the anchorage requirement for survival and the function of the p53 tumor suppressor gene are subverted. These effects are consistent with the hypothesis that survival signals from extracellular matrix (ECM) suppress a p53-regulated cell death pathway. We report that survival signals from fibronectin are transduced by the focal adhesion kinase (FAK). If FAK or the correct ECM is absent, cells enter apoptosis through a p53-dependent pathway activated by protein kinase C lambda/iota and cytosolic phospholipase A2. This pathway is suppressible by dominant-negative p53 and Bcl2 but not CrmA. Upon inactivation of p53, cells survive even if they lack matrix signals or FAK. This is the first report that p53 monitors survival signals from ECM/FAK in anchorage- dependent cells.     

Prenatal cocaine but not prenatal malnutrition affects foster mother-pup interactions in rats

The separate and combined effects of prenatal cocaine exposure and malnutrition on mother-pup interactions in rats were assessed daily from postnatal day 2 to day 21. Sprague-Dawley dams were fed a diet of low protein content (6% casein), an isocaloric diet of adequate protein content (25% casein, control), or a laboratory chow diet prior to mating and throughout pregnancy. Within each diet group, rats received either cocaine injections (30 mg/kg IP two times per week prior to mating and then 30 mg/kg SC daily from days 3 to 18 of pregnancy) or saline injections. Litters were fostered on the day of birth to control mothers (i.e., nondrug-exposed dams fed the control or chow diet). Foster mothers fed the 25% casein diet showed increased contact with cocaine-exposed pups compared with nondrug-exposed pups in the second postnatal week but lower levels as the pups approached weaning. Passive nursing was increased in dams caring for prenatally malnourished, cocaine-exposed pups compared with those caring for similar pups with no drug exposure. Chow-fed mothers did not differ in their behavior towards pups with or without prenatal cocaine treatment. Prenatal cocaine and malnutrition independently compromised birth weight and various reflexive milestones but the attainment of physical milestones was affected only by prenatal cocaine. There were no additive effects of the two prenatal insults on any measure of mother-pup interaction or pup development.     

Medium term observation of shiprepair and shipbuilding docks

This paper describes the observation of the structural behaviour of two of the largest docks in the world, the Setenave docks, as well as the experimental techniques developed by LNEC for observing this type of structures. This work was considered of fundamental importance not only for checking the safety conditions of the dock structural behaviour, but also for the progress of design methods of these structures, especially as concerns the interaction between soil, piles and bottom slabs. In accordance with the programme of observation, we had the opportunity to appreciate the behaviour of the sunk docks under the following conditions: during the elevation of the ground-water level, which had been lowered for the construction of the docks; during successive filling and emptying operations in docks for the repair of several ships; and also during the simultaneous flooding of the two docks up to the level +4.2 m above the land area for the launching of a ship constructed in the shipbuilding dock.

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Résumé Cet article rend compte de l'observation du comportement de deux des docks les plus importants du monde, les docks Setenave, ainsi que des techniques expérimentales mises au point par le LNEC pour l'observation de ce type de structure. Cette étude a été considérée comme étant d'une importance fondamentale non seulement pour vérifler les conditions de sécurité du comportement structurel des docks mais aussi pour le progrès des méthodes de conception de ce type de structure, particulièrement en ce qui concerne l'interaction entre le sol, les piliers et les dalles de fondation. En correspondance avec ce programme d'observation, on a pu estimer le comportement des docks immergés dans les conditions suivantes: au cours de l'élévation du niveau de l'eau souterraine qui avait été abaissé pour la construction des docks; au cours des opérations de remplissage et de vidage successives des docks pour la réparation des navires; également au cours du remplissage simultané des deux docks jusqu'au niveau+4.2 m au-dessus du sol pour le lancement d'un navire dans le dock de construction.

     

A wavelet-based ECG delineator: evaluation on standard databases

In this paper, we developed and evaluated a robust single-lead electrocardiogram (ECG) delineation system based on the wavelet transform (WT). In a first step, QRS complexes are detected. Then, each QRS is delineated by detecting and identifying the peaks of the individual waves, as well as the complex onset and end. Finally, the determination of P and T wave peaks, onsets and ends is performed. We evaluated the algorithm on several manually annotated databases, such as MIT-BIH Arrhythmia, QT, European ST-T and CSE databases, developed for validation purposes. The QRS detector obtained a sensitivity of Se = 99.66% and a positive predictivity of P+ = 99.56% over the first lead of the validation databases (more than 980,000 beats), while for the well-known MIT-BIH Arrhythmia Database, Se and P+ over 99.8% were attained. As for the delineation of the ECG waves, the mean and standard deviation of the differences between the automatic and manual annotations were computed. The mean error obtained with the WT approach was found not to exceed one sampling interval, while the standard deviations were around the accepted tolerances between expert physicians, outperforming the results of other well known algorithms, especially in determining the end of T wave.     

Enhancing the experience of 3D virtual worlds with a cartographic generalization approach

In this work we propose a new approach for fast visualization and exploration of virtual worlds based on the use of cartographic concepts and techniques. Versions of cartographic maps with different levels of details can be created by using a set of operations named cartographic generalization. Cartographic generalization employs twelve operators and domain-specific knowledge, being the contribution of this work their transposition to 3D virtual worlds. The architecture of a system for 3D generalization is proposed and the system is implemented. Differently from traditional cartographic processes, we use artificial intelligence for both selecting the key objects and applying the operators. As a case study, we present the simplification of the historical quarter of Recife (Brazil).     

Data structures for the distributed iterative solution of non-conventional finite element models

A class of specialised data structures designed for the distributed solution of non-conventional finite element formulations, which are equally effective when used in conjunction with conventional formulations, is presented. We begin by briefly discussing how the non-conventional finite element formulations being developed within the structural analysis group at IST [Freitas JAT, Almeida JPM, Pereira EMBR. Non-conventional formulations for the finite element method. Comput Mech 1999;23(5–6):488–501] lead to systems of equations that appear to be naturally suited for parallel processing, but we also recognise that to take full advantage of the characteristics of these systems – large dimension, non-overlapping block structure and sparsity – it is necessary to use appropriate data structures. The approach presented, which references the logical subdivisions of the system matrices, was designed to fulfil these objectives. Examples of parallel performance and efficiency on an homogeneous distributed platform are presented.