Scarring trachoma is associated with polymorphism in the tumor necrosis factor alpha (TNF-alpha) gene promoter and with elevated TNF-alpha levels in tear fluid

Tumor necrosis factor alpha (TNF-alpha) may play a central role in the disease pathogenesis which occurs as a consequence of chlamydial infection. To investigate the importance of TNF-alpha gene promoter polymorphisms and TNF-alpha levels in tear fluid in scarring trachoma, a large matched-pair case-control study was performed in The Gambia. The -308A allele was present in a higher proportion of patients (28.4%) than controls (18.4%), with an increasing association for homozygotes (chi2 for trend, P = 0.032; allele frequency, 0.163 in patients and 0.099 in controls; chi2, P = 0.025). For the -238A allele, the association was similar but not significant. The disease association was highly significant when the number of either -308A or -238A sites in an individual was considered (P = 0.003). TNF-alpha promoter alleles are tightly linked to some HLA class I and II alleles, but multivariate analysis confirmed that the disease associations were independent of HLA, although a class I allele, A*6802, is also associated with disease. TNF-alpha was more frequently detected in tear samples from patients (27.6%) than from controls (15.9%), increasingly so for higher levels of detectable TNF-alpha (P = 0.015). Among patients, detectable TNF-alpha in tears was highly associated with the presence of ocular chlamydial infection (P < 0.001). The results indicate that TNF-alpha plays a major role in the tissue damage and scarring which occurs as a consequence of Chlamydia trachomatis infection.     

Selectivity Enhancement to the Exclusive Formation of Ethyltoluenes and Hydrogen During Dehydroalkylation of Toluene with Ethane

The dehydroalkylation of toluene with ethane to the isomeric ethyltoluenes was studied on 0.4Pt/H-ZSM-5 at varying contact times (1/WHSV). At a high contact time of 1.0 h, toluene disproportionation and hydrogenolysis reactions dominate, resulting in low selectivity to the desired ethyltoluenes via the alkylation reaction. However, at a low contact time of 0.12 h side reactions are eliminated, resulting in maximum selectivities to the kinetically favored ethyltoluenes and hydrogen. Results at high selectivities to ethyltoluenes provide significant insight into reaction pathways.     

Cit-CSP及其应用

介绍了Cit-CSP--Cit/E-commerce信息安全保障平台子系统，并阐述了它所提供的消息摘要、块加密、加密(公钥)、签名和MAC等功能和服务。     

Reconstruction of reflectance spectra using weighted principal component analysis

The weighted principal component analysis technique is employed for reconstruction of reflectance spectra of surface colors from the related tristimulus values. A dynamic eigenvector subspace based on applying certain weights to reflectance data of Munsell color chips has been formed for each particular sample and the color difference value between the target, and Munsell dataset is chosen as a criterion for determination of weighting factors. Implementation of this method enables one to increase the influence of samples which are closer to target on extracted principal eigenvectors and subsequently diminish the effect of those samples which benefit from higher amount of color difference. The performance of the suggested method is evaluated in spectral reflectance reconstruction of three different collections of colored samples by the use of the first three Munsell bases. The resulting spectra show considerable improvements in terms of root mean square error between the actual and reconstructed reflectance curves as well as CIELAB color difference under illuminant A in comparison to those obtained from the standard PCA method. © 2008 Wiley Periodicals, Inc. Col Res Appl, 33, 360–371, 2008     

A Probabilistic Multiperiod Simulation–Optimization Approach for Dynamic Coastal Aquifer Management

Combined simulation–optimization (CSO) schemes are common in the literature to solve different groundwater management problems, and CSO is particularly well-established in the coastal aquifer management literature. However, with a few exceptions, nearly all previous studies have employed the CSO approach to derive static groundwater management plans that remain unchanged during the entire management period, consequently overlooking the possible positive impacts of dynamic strategies. Dynamic strategies involve division of the planning time interval into several subintervals or periods, and adoption of revised decisions during each period based on the most recent knowledge of the groundwater system and its associated uncertainties. Problem structuring and computational challenges seem to be the main factors preventing the widespread implementation of dynamic strategies in groundwater applications. The objective of this study is to address these challenges by introducing a novel probabilistic Multiperiod CSO approach for dynamic groundwater management. This includes reformulation of the groundwater management problem so that it can be adapted to the multiperiod CSO approach, and subsequent employment of polynomial chaos expansion-based stochastic dynamic programming to obtain optimal dynamic strategies. The proposed approach is employed to provide sustainable solutions for a coastal aquifer storage and recovery facility in Oman, considering the effect of natural recharge uncertainty. It is revealed that the proposed dynamic approach results in an improved performance by taking advantage of system variations, allowing for increased groundwater abstraction, injection and hence monetary benefit compared to the commonly used static optimization approach.

     

Design and implementation of a new tuned hybrid intelligent model to predict the uniaxial compressive strength of the rock using SFS-ANFIS

This study proposes a novel design to systematically optimize the parameters for the adaptive neuro-fuzzy inference system (ANFIS) model using stochastic fractal search (SFS) algorithm. To affirm the efficiency of the proposed SFS-ANFIS model, the predicting results were compared with ANFIS and three hybrid methodologies based on ANFIS combined with genetic algorithm (GA), differential evolution (DE), and particle swarm optimization (PSO). Accurate prediction of uniaxial compressive strength (UCS) is of great significance for all geotechnical projects such as tunnels and dams. Hence, this study proposes the use of SFS-ANFIS, GA-ANFIS, DE-ANFIS, PSO-ANFIS, and ANFIS models to predict UCS. In this regard, the fresh water tunnel of Pahang–Selangor located in Malaysia was considered and the requirement data samples were collected. Different statistical metrics such as coefficient of determination (R²) and mean absolute error were used to evaluate the models. Referring to the efficiency results of SFS-ANFIS, it can be found that the SFS-ANFIS (with the R² of 0.981) has higher ability than PSO-ANFIS, DE-ANFIS, GA-ANFIS, and ANFIS models in predicting the UCS.

     

Predicting the blast-induced vibration velocity using a bagged support vector regression optimized with firefly algorithm

Ground vibration is the most detrimental effect induced by blasting in surface mines. This study presents an improved bagged support vector regression (BSVR) combined with the firefly algorithm (FA) to predict ground vibration. In other words, the FA was used to modify the weights of the SVR model. To verify the validity of the BSVR–FA, the back-propagation neural network (BPNN) and radial basis function network (RBFN) were also applied. The BSVR–FA, BPNN and RBFN models were constructed using a comprehensive database collected from Shur River dam region, in Iran. The proposed models were then evaluated by means of several statistical indicators such as root mean square error (RMSE) and symmetric mean absolute percentage error. Comparing the results, the BSVR–FA model was found to be the most accurate to predict ground vibration in comparison to the BPNN and RBFN models. This study indicates the successful application of the BSVR–FA model as a suitable and effective tool for the prediction of ground vibration.

     

A novel approach to predict shear strength of tilted angle connectors using artificial intelligence techniques

Shear connectors play a prominent role in the design of steel-concrete composite systems. The behavior of shear connectors is generally determined through conducting push-out tests. However, these tests are costly and require plenty of time. As an alternative approach, soft computing (SC) can be used to eliminate the need for conducting push-out tests. This study aims to investigate the application of artificial intelligence (AI) techniques, as sub-branches of SC methods, in the behavior prediction of an innovative type of C-shaped shear connectors, called Tilted Angle Connectors. For this purpose, several push-out tests are conducted on these connectors and the required data for the AI models are collected. Then, an adaptive neuro-fuzzy inference system (ANFIS) is developed to identify the most influencing parameters on the shear strength of the tilted angle connectors. Totally, six different models are created based on the ANFIS results. Finally, AI techniques such as an artificial neural network (ANN), an extreme learning machine (ELM), and another ANFIS are employed to predict the shear strength of the connectors in each of the six models. The results of the paper show that slip is the most influential factor in the shear strength of tilted connectors and after that, the inclination angle is the most effective one. Moreover, it is deducted that considering only four parameters in the predictive models is enough to have a very accurate prediction. It is also demonstrated that ELM needs less time and it can reach slightly better performance indices than those of ANN and ANFIS.

     

GA-SVR: a novel hybrid data-driven model to simulate vertical load capacity of driven piles

Piles are widely applied to substructures of various infrastructural buildings. Soil has a complex nature; thus, a variety of empirical models have been proposed for the prediction of the bearing capacity of piles. The aim of this study is to propose a novel artificial intelligent approach to predict vertical load capacity of driven piles in cohesionless soils using support vector regression (SVR) optimized by genetic algorithm (GA). To the best of our knowledge, no research has been developed the GA-SVR model to predict vertical load capacity of driven piles in different timescales as of yet, and the novelty of this study is to develop a new hybrid intelligent approach in this field. To investigate the efficacy of GA-SVR model, two other models, i.e., SVR and linear regression models, are also used for a comparative study. According to the obtained results, GA-SVR model clearly outperformed the SVR and linear regression models by achieving less root mean square error (RMSE) and higher coefficient of determination (R²). In other words, GA-SVR with RMSE of 0.017 and R² of 0.980 has higher performance than SVR with RMSE of 0.035 and R² of 0.912, and linear regression model with RMSE of 0.079 and R² of 0.625.