Localized eosinophilic granuloma (Langerhans' cell histiocytosis) of the orbital frontal bone

Four patients (aged 5, 8, 14, and 51 years at initial manifestation) with isolated eosinophilic granulomas of the orbital frontal bone displayed short symptomatic periods (two weeks to three months) and some combination of erythema of the lids, a soft, palpable anterior orbital mass, periorbital pain, and osteolytic bone lesions on roentgenography. The bone lesions roentgenographically exhibited irregular, serrated, and sclerotic margins, distinguishing them from the more oval appearance of dermoid cysts. Electron microscopy performed in one case disclosed the presence of Langerhans' granules in the cytoplasm of the histiocytes, indicating that the orbital disease is a mild form of "histiocytosis X" and a benign proliferation of a specific kind of histiocyte--the Langerhans' cell. On follow-up (two to 20 years), after incomplete curettage of two lesions coupled with low doses of postoperative radiotherapy, there was reconstitution of the bone defects, whereas more extensive surgery performed on the other two patients resulted in permanent but subclinical bone defects.     

Mode matching for a passive resonant ring laser gyroscope

An analytical method of matching the mode of an input laser to the lowest-order mode of a passive resonant ring laser gyro is described, as are the steps in determining the location and focal length of cylindrical mode matching lenses. Results were obtained with no mode matching, with a compromise spherical lens, with horizontal mode matching only, and with the proper cylindrical mode matching lenses. Compared with no mode matching, the latter case shows that the amplitude of the lowest-order mode is increased approximately 2.5 times. In addition, the number and intensity of higher-order modes are reduced to near zero, and the relative intensity of the lowest-order mode to the higher-order mode increased from approximately 5 to approximately 60 times greater.     

Biogenesis of cellulolytic enzymes by Trichoderma ligorum on media with "inductor"

Identical distribution of C2- and Cx-cellulase activities of enzyme complexes produced by Trichoderma lignorum on a medium with lactose, a soluble "inductor", and on a medium with cellulose was found by means of disc elestrophoresis in polyacrylamide gel. The maximum rate of synthesis of cellulases on the medium with lactose was registered during the highest deceleration, and even complete cessation, of the fungal growth. During this phase, only one electrophoretically homogeneous cellulase component with Rf of 0.44 possessing all types of the cellulase activity is present in the cultural broth. In the course of growth of the fungus on cellulose after 48 hours, also only one electrophoretically homogeneous component with Rf of 0.44 was found in the cultural broth when the rate of the substrate degradation was highest. The appearance of minor protein components with the activity of cellulase at later stages of cultivation after cessation of the fungal growth is supposed to be caused by modification of the main cellulase component with Rf of 0.44 by the growth medium.     

Sex typing and androgyny: further explorations of the expressive domain

Previous research by Bem has indicated that androgynous individuals of both sexes display "masculine" independence when under pressure to conform as well as "feminine" nurturance when interacting with a kitten. In contrast, sex-typed individuals were low in one or both of these behaviors. The two studies reported here were designed to replicate the low nurturance of the masculine male and to clarify the unexpected finding that feminine females were low in both independence and nurturance. In the first study subjects interacted with a human infant, and in the second study they listened to a lonely student. Taken together, the results of these two studies conceptually replicated the low nurturance of the masculine male and demonstrated that the low nurturance of the feminine female does not extend to her interaction with humans. Finally, evidence was presented in support of Spence, Helmreich, and Stapp's distinction between "androgynous" individuals, who are high in both masculinity and feminity, and "undifferentiated" individuals, who are low in both of these characteristics.     

A comparative study of exchange and aggregation models in the B2B e-marketplace

This research seeks to provide an economic framework for understanding two major forms of e-marketplaces: aggregation-oriented vs. exchange-oriented e-marketplaces. By analyzing the marginal benefit per transaction in alternative models, we are able to determine the most suitable B2B e-marketplace for a wide variety of product categories, market conditions, and procurement methods. For example, when companies sell commodities in a fragmented market, the aggregation model is suitable for spot purchasing, and the exchange model works best for systematic purchasing. In addition, the effect of supplier consolidation and information technology-enabled cost reduction on model selection is discussed.     

Two-handed volumetric document corpus management

To find a document in the sea of information, you must embark on a search process, usually computer-aided. In the traditional information retrieval model, the final goal is to identify and collect a small number of documents to read in detail. In this case, a single query yielding a scalar indication of relevance usually suffices. In contrast, document corpus management seeks to understand what is happening in the collection of documents as a whole (i.e. to find relationships among documents). You may indeed read or skim individual documents, but only to better understand the rest of the document set. Document corpus management seeks to identify trends, discover common links and find clusters of similar documents. The results of many single queries must be combined in various ways so that you can discover trends. We describe a new system called the Stereoscopic Field Analyzer (SFA) that aids in document corpus management by employing 3D volumetric visualization techniques in a minimally immersive real-time interaction style. This interactive information visualization system combines two-handed interaction and stereoscopic viewing with glyph-based rendering of the corpora contents. SFA has a dynamic hypertext environment for text corpora, called Telltale, that provides text indexing, management and retrieval based on n-grams (n character sequences of text). Telltale is a document management and information retrieval engine which provides document similarity measures (n-gram-based m-dimensional vector inner products) visualized by SFA for analyzing patterns and trends within the corpus     

The Effects of Process Characteristics on the Value of B2B E-Procurement

Even as more organizations are moving towards implementing Web-based B2B procurement solutions, they are unsure of the real benefits of the Web. In other words, what is the value of B2B e-procurement to an organization and how to measure this value? What factors affect this value? In this paper, we discuss an evaluation framework to determine the value of B2B e-procurement and the effect of process characteristics on the value. We use an empirical study to highlight the different value created by different procurement types. We then develop a more comprehensive economic model to capture the additional effects of demand volume and process complexity. The integration of theoretical and empirical approaches provides a strong foundation to develop and evaluate useful adoption strategies for B2B e-procurement.     

Decreased Expression of Plakophilin-2 and αT-Catenin in Arrhythmogenic Right Ventricular Cardiomyopathy: Potential Markers for Diagnosis

Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a hereditary disease of the heart muscle. Clinical challenges remain, however, in identifying patients with ARVC in the early or concealed stages with subtle clinical manifestations. Therefore, we wanted to identify potential targets by immunohistochemical (IHC) analysis in comparison with controls. Pathogenic mutations were identified in 11 of 37 autopsied patients with ARVC. As observed from IHC analysis of the RV, expression of αT-catenin and plakophilin-2 is significantly decreased in autopsied patients with ARVC as compared to controls, and the decreased expression is consistent in patients with and without pathogenic mutations. Furthermore, ARVC specimens demonstrated a reduced localization of αT-catenin, desmocollin-2, desmoglein-2, desmoplakin, and plakophilin-2 on intercalated discs. These findings have been validated by comparing RV specimens obtained via endomyocardial biopsy between patients with ARVC and those without. The pathogenic mutation was present in 3 of 5 clinical patients with ARVC. In HL-1 myocytes, siRNA was used to knockdown CTNNA3, and western blotting analysis demonstrated that the decline in αT-catenin expression was accompanied by a significant decline in the expression of plakophilin-2. The aforementioned effect was directed towards protein degradation rather than mRNA stability. Plakophilin-2 expression decreases concurrently with the decline in CTNNA3 expression. Therefore, the expression of αT-catenin and plakophilin-2 could be potential surrogates for the diagnosis of ARVC.     

基于模糊穴─穴映射的多变量模糊系统分析

在简要介绍多变量模糊系统的模糊穴－穴映射（ＦＣＭ－Ｉ）模型的基础上，提出了一种对多变量模糊系统进行分解的方法。此法的核心在于认为任何复杂系统的动态都是由其隐含的稳定子动态和不稳定于动态聚合而成，而系统特性则主要取决于决定性子动态的性质。并介绍了确定系统决定性子动态和基于其上的多变量模糊系统渐近分析方法。