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11.
Y. Iwadate K. Fukushima Y. Seki K. Itoh T. Fukunaga M. Misawa H. Matsuura A. Kajinami N. Ohtori N. Umesaki H. Kofuji M. Myochin 《Science and Technology of Advanced Materials》2004,5(5-6):683
Although the melt structure of glass-forming ZnCl2 has so far been well studied, there exists quite little information on the structural change due to anion-substitution. In the present work, the short-range structure of ZnCl2–ZnBr2 mixture melts was analyzed systematically by time-of-flight pulsed neutron diffraction techniques, Raman spectroscopy, molecular orbital calculations, and molecular dynamics simulations. According to radial distribution analysis, it was found that there were tetrahedral structural units of ligand-substituted [ZnClnBr4−n]2− (n=0–4) in these melts, not implying the simple mixing of [ZnCl4]2− and [ZnBr4]2− units. Further detailed estimation indicated that the ligand-substituted complex anions were linked with each other by sharing a common anion. 相似文献
12.
Atsushi Kanamori Fumio Tanaka Masaki Ominami Yuji Nadatani Shusei Fukunaga Koji Otani Shuhei Hosomi Noriko Kamata Yasuaki Nagami Koichi Taira Yasuhiro Fujiwara 《International journal of molecular sciences》2022,23(15)
The effects of psychological stress on eosinophilic gastrointestinal disorders have not been elucidated. This study investigated the effects of psychological stress in a mouse model of eosinophilic enteritis (EoN). BALB/c mice were treated with ovalbumin (OVA) to create an EoN model and subjected to either water avoidance stress (WAS) or sham stress (SS). Microscopic inflammation, eosinophil and mast cell counts, mRNA expression, and protein levels of type 2 helper T cell (Th2) cytokines in the ileum were compared between groups. We evaluated ex vivo intestinal permeability using an Ussing chamber. A corticotropin-releasing hormone type 1 receptor (CRH-R1) antagonist was administered before WAS, and its effects were analyzed. WAS significantly increased diarrhea occurrence and, eosinophil and mast cell counts, and decreased the villus/crypt ratio compared to those in the SS group. The mRNA expression of CRH, interleukin IL-4, IL-5, IL-13, eotaxin-1, and mast cell tryptase β2 significantly increased, and the protein levels of IL-5, IL-13, and OVA-specific immunoglobulin E (IgE) also significantly increased in the WAS group. Moreover, WAS significantly increased the intestinal permeability. The CRH-R1 antagonist significantly inhibited all changes induced by WAS. Psychological stress exacerbated ileal inflammation via the CRH-mast cell axis in an EoN mouse model. 相似文献
13.
Ichiro Kawahata David I. Finkelstein Kohji Fukunaga 《International journal of molecular sciences》2022,23(11)
α-Synuclein is a protein with a molecular weight of 14.5 kDa and consists of 140 amino acids encoded by the SNCA gene. Missense mutations and gene duplications in the SNCA gene cause hereditary Parkinson’s disease. Highly phosphorylated and abnormally aggregated α-synuclein is a major component of Lewy bodies found in neuronal cells of patients with sporadic Parkinson’s disease, dementia with Lewy bodies, and glial cytoplasmic inclusion bodies in oligodendrocytes with multiple system atrophy. Aggregated α-synuclein is cytotoxic and plays a central role in the pathogenesis of the above-mentioned synucleinopathies. In a healthy brain, most α-synuclein is unphosphorylated; however, more than 90% of abnormally aggregated α-synuclein in Lewy bodies of patients with Parkinson’s disease is phosphorylated at Ser129, which is presumed to be of pathological significance. Several kinases catalyze Ser129 phosphorylation, but the role of phosphorylation enzymes in disease pathogenesis and their relationship to cellular toxicity from phosphorylation are not fully understood in α-synucleinopathy. Consequently, this review focuses on the pathogenic impact of α-synuclein phosphorylation and its kinases during the neurodegeneration process in α-synucleinopathy. 相似文献
14.
Shoko Kasuga Ryota Mori Shunichi Kasahara Junichi Rekimoto 《International journal of human-computer interaction》2019,35(15):1345-1351
Growing evidence suggests that the gradual transformation of visuomotor association drives a distinct learning process from abrupt transformation in humans. In the current study, we developed a novel omnidirectional visuomotor transformation paradigm to study details of such difference in more realistic environment than conventional experimental systems. Participants were asked to perform a repetitive three-dimensional (3D) arm-reaching task to a target on a front touch panel, wearing a video see-through head-mounted device that displayed a rotating view of surrounding images. In the abrupt condition, the images were rotated by 20°; in the gradual condition, the rotation was increased in a stepwise-manner from 0° to 20°. In both conditions, pointing errors were decreased after adaptation. Further, although the aftereffect of adaptation was not different between conditions, the speed of decay of the aftereffect, which was quantified by an exponential fit, was slower in the gradual condition, suggesting longer-lasting aftereffects for the gradual shift. 相似文献
15.
16.
Yuji Oda Mihe Yabuki Kenzo Tonomura Masahito Fukunaga 《Yeast (Chichester, England)》1997,13(13):1243-1250
Sequences of two internally transcribed spacer regions between 18S and 28S rRNA genes were determined to assess the phylogenetic relationship in the strains belonging to the genus Saccharomyces. The sequences of S. bayanus and S. pastorianus were quite similar, but not identical. Two phylogenetic trees constructed by the neighbor-joining method showed that all the species examined were distinguished from one another. The Saccharomyces sensu stricto species: S. cerevisiae, S. bayanus, S. paradoxus and S. pastorianus, were closely related and far from the Saccharomyces sensu lato species including S. barnetti, S. castellii, S. dairensis, S. exiguus, S. servazzii, S. spencerorum and S. unisporus, and an outlying species, S. kluyveri. © 1997 John Wiley & Sons, Ltd. 相似文献
17.
Kentaro Yanagihara Jumpei Taketsugu Kiyoshi Fukui Shigeru Fukunaga Shinsuke Hara Ken-ichi Kitayama 《Wireless Personal Communications》2007,40(3):401-415
In this paper, we propose a new energy efficient clustering scheme with transmission power control named “EACLE” (Energy-Aware
CLustering scheme with transmission power control for sEnsor networks) for wireless sensor networks, which are composed of
the following three components; “EACLE clustering” is a distributed clustering method by means of transmission power control,
“EACLE routing” builds a tree rooted at a sink node and sets the paths from sensor nodes taking energy saving into consideration,
and “EACLE transmission timing control” changes the transmission timing with different levels of transmission power to avoid
packet collisions and facilitates packet binding.
With an indoor wireless channel model which we obtained from channel measurement campaigns in rooms and corridors and an energy
consumption model which we obtained from a measurement of a chipset, we performed computer simulations to investigate the
performance of EACLE in a realistic environment. Our simulation results indicate that EACLE outperforms a conventional scheme
such as EAD (Energy-Aware Data-centric routing) in terms of communication success rate and energy consumption. Furthermore,
we fully discuss the impact of transmission power and timing control on the performance of EACLE. 相似文献
18.
Graded evolution of anisotropic microstructure during sintering from crystal-oriented powder compact
Shoko Baba Alexandre Maître Nicolas Pradeilles Guy Antou Nobuo Saito Satoshi Tanaka 《International Journal of Applied Ceramic Technology》2020,17(2):677-684
Anisotropic sintering, including shrinkage and grain growth, was examined for c-axis-oriented (Sr,Ca)2NaNb5O15 (SCNN) ceramics, which were prepared by colloidal processing under a magnetic field. In the c-axis-oriented SCNN powder compact, shrinkage and grain growth along the c-axis were higher than those along the a-axis. The anisotropic microstructural development was clearly associated with anisotropic sintering shrinkage. X-ray diffraction, scanning electron microscopy, and energy back scattering diffraction showed that the grain growth of oriented particles by including random grains contribute to the development of the oriented microstructure. Finally, the highly crystal-oriented SCNN ceramics with a densified microstructure were obtained through anisotropic sintering. These results clearly showed the potential to develop a well-defined anisotropic microstructure during sintering by designing and controlling the particle packing structure in a powder compact. 相似文献
19.
Hiroyuki Hamada Hiroyuki Kato Naoto Ito Yoshihiko Takase Hironobu Nanbu Shoko Mishima Hiromu Sakaki Kiyotaka Sato 《European Journal of Lipid Science and Technology》2010,112(12):1323-1330
Biodiesel fuels (BDF) have many problems in the cold due to their crystallization properties. In particular, precipitation of large crystals of high‐melting fractions in BDF at low temperatures remarkably changes cold flow property of BDF and, thereby, it increases the values of cold filter plugging point. In this study, we evaluated polyglycerol esters of fatty acids (PGE) and ethylene‐vinyl acetate co‐polymer (EVA) as chemical additives to improve the cold flow property of palm oil‐based FAME (PFME). The results of solid fat content measurement indicate that the simultaneous addition of PGE and EVA showed synergistic effects on suppression of crystallization of PFME, however such effect was not observed when EVA was used alone. DSC thermograms indicated that the PGE additives not only decreased the crystallization temperature but also kinetically suppressed the crystal growth. Polarized light microscopy showed that the simultaneous addition of PGE and EVA led to the formation of considerably small and fine‐dispersed crystals of PFME. These results indicate that combined effects of PGE and EVA caused the formation of fine‐dispersed PFME crystals, which could improve the viscous properties of palm oil‐based BDF at relatively cold temperatures. 相似文献
20.
Hiroaki Ohfuji Takuo Okuchi Shoko Odake Hiroyuki Kagi Hitoshi Sumiya Tetsuo Irifune 《Diamond and Related Materials》2010,19(7-9):1040-1051
Micrometer- to nanometer-scale structures of the cut surfaces of single- and polycrystalline diamonds by a pulsed ultraviolet laser have been thoroughly investigated by scanning and transmission electron microscopy. Within the laser-cut grooves, the processed diamond surfaces are extensively covered with laser-modified debris which consists of complex layered units of graphite with various crystallinities. The units consist of 1) highly oriented graphite, 2) corrugated graphite, and 3) nanocrystalline graphite, which are sequentially located from the surface of the underlying diamond substrate to the center of the grooves. Detailed textural examinations revealed that the highly oriented graphite unit is a product of the initial graphitization of diamond by a solid-state diffusion process, whereas the latter two units are deposition products from the liquid and/or vapor phases of carbon in the later stage. The present study demonstrates that the laser-cutting of diamonds proceeds in a two-step process: 1) extensive graphitization of laser-scanning path and 2) subsequent sublimation of the pre-formed graphite. These processes are basically identical among the three different types of diamonds (single crystal type Ib, single crystal type IIa and nano-polycrystalline aggregate) tested in this study. 相似文献