Effect of thin Mo2C layer on thermal stability of Si/SiO2/Ti/Cu system

The effect of introducing a thin Mo₂C (30 nm) layer between Ti and Cu on the thermal stability of Si/SiO₂/Ti/Cu system was studied using four-point probe (FPP), scanning electron microscopy (SEM), energy-dispersive X-ray spectroscopy (EDAX) and X-ray diffraction (XRD) techniques. The measured value of the sheet resistance in the bi-layered diffusion barrier structure does not show any change up to an annealing temperature of 750??C. The sheet resistance when measured after annealing at 800??C marginally increases but less than twice its value at room temperature. The XRD analysis indicated no copper diffusion and the formation of Cu₃Si phase up to 800??C. The bi-layered barrier structure annealed at elevated temperature shows copper-depleted and agglomerated regions. The sheet resistance measurement, study of surface morphology and the XRD analysis confirm that the insertion of thin Mo₂C layer increases the thermal stability of the system from 400??C to 750??C. The increased thermal stability of the system is ascribed to longer diffusion path length in the bi-layered system probably because of grain boundaries mismatch at Ti-Mo₂C interface.     

Epitope mapping of a 95 kDa antigen in complex with antibody by solution-phase amide backbone hydrogen/deuterium exchange monitored by Fourier transform ion cyclotron resonance mass spectrometry

The epitopes of a homohexameric food allergen protein, cashew Ana o 2, identified by two monoclonal antibodies, 2B5 and 1F5, were mapped by solution-phase amide backbone H/D exchange (HDX) coupled with Fourier transform ion cyclotron resonance mass spectrometry (FTICR MS) and the results were compared to previous mapping by immunological and mutational analyses. Antibody 2B5 defines a conformational epitope, and 1F5 defines a linear epitope. Intact murine IgG antibodies were incubated with recombinant Ana o 2 (rAna o 2) to form antigen-monoclonal antibody (Ag-mAb) complexes. mAb-complexed and uncomplexed (free) rAna o 2 were then subjected to HDX. HDX instrumentation and automation were optimized to achieve high sequence coverage by protease XIII digestion. The regions protected from H/D exchange upon antibody binding overlap and thus confirm the previously identified epitope-bearing segments: the first extension of HDX monitored by mass spectrometry to a full-length antigen-antibody complex in solution.     

Dielectric and electro-optical study of ZnO nano rods doped ferroelectric liquid crystals

Addition of Nano rods results change in the dielectric and electro-optical properties of pure Ferroelectric Liquid Crystal (FLC) considerably. The present study is devoted to characterize the dielectric and electro-optical parameters of the FLC nano rods composite system. The size of nano rods is usually much bigger than that of FLC molecules, therefore, when they are doped in different concentrations, in pure FLC, their volume fraction plays considerable role in deciding the molecular dynamics of the resultant composite system. For the lesser concentrations, the nano rods offer mechanical strength to system geometry while at higher concentration of nano rods, they offer additional constraints on the system. In present report both of these aspects have been analyzed and explained.     

ABC transporters Cdr1p, Cdr2p and Cdr3p of a human pathogen Candida albicans are general phospholipid translocators

We have used fluorescent 7-nitrobenz-2-oxa-1,3-diazol-4-yl (NBD)-tagged phospholipid analogues, NBD-PE (phosphatidylethanolamine), NBD-PC (phosphatidylcholine) and NBD-PS (phosphatidylserine), to demonstrate that Cdr1p and its other homologues, Cdr2p and Cdr3p, belonging to the ATP-binding cassette (ABC) superfamily behave as general phospholipid translocators. Interestingly, CDR1 and CDR2, whose overexpression leads to azole resistance in C. albicans, elicit in-to-out transbilayer phospholipid movement, while CDR3, which is not involved in drug resistance, carries out-to-in translocation of phospholipids between the two monolayers of plasma membrane. Cdr1p, Cdr2p and Cdr3p could be further distinguished on the basis of their sensitivities to different inhibitors. For example, the in-to-out activity associated with Cdr1p and Cdr2p is energy-dependent and sensitive to sulphydryl blocking agents such as N-ethylmaleimide (NEM) and cytoskeleton disrupting agent cytochalasin E, while Cdr3p-associated out-to-in activity is energy-dependent but insensitive to NEM and cytochalasin E. We found that certain drugs, such as fluconazole, cycloheximide and miconazole, to which Cdr1p confers resistance could also affect in-to-out transbilayer movement of NBD-PE, while the same drugs had no effect on Cdr3p-mediated out-to-in translocation of NBD-PE. The ineffectiveness of these drugs to affect Cdr3p mediated out-to-in phospholipid translocation further confirms the inherent difference in the directionality of phospholipid translocation between these pumps. Notwithstanding the role of some of the Cdrps in drug resistance, this study clearly demonstrates that these ABC transporters of C. albicans are phospholipid translocators and this function could represent one of the physiological functions of such large family of proteins.     

Central modulation of Brewer''s yeast-induced peripheral inflammation by neuropeptides bradykinin and substance P

This study reports the results of some voluntary Italian radiologists performing 103 proficiency tests in clinical (100 patients, 32 cancers) and screening mammography (150 patients, 17 cancers). Relative to the average accuracy of a panel of expert radiologists, 12 of 49 readers (27%) and 32 of 54 readers (56%) passed the clinical and screening mammography test, respectively. The results were significantly correlated with the readers' previous experience (years of mammographic practice [< 2, 2-4, > 4] and number of mammograms read [< 5,000, 5-10,000, > 10,000]). The rate of passed test was: < 2 years = 0%, 2-4 years = 40%, > 4 years = 66.6% (P = 0.002); < 5,000 mammograms read = 15.3%, 5-10,000 = 28.5%, > 10,000 = 69.2% (P = 0.02). The best results were achieved by the readers with a previous reading experience of at least 10,000 mammograms, a figure which might be used as the reference for a future criterion of accreditation on a national basis. Proper training before reporting mammography is fundamental to ensure a good diagnostic performance. The low number of tests performed in most Italian mammographic practice facilities makes local training highly questionable and requires quite a long time. Reference centers, adequately equipped for training, should be identified for this purpose. Proficiency tests such as those described in the present study are useful to assess individual performance and should be a part of a training program.     

Thrombosis of tibial arteries in a patient receiving tamoxifen therapy

BACKGROUND: Tamoxifen has been used extensively as adjuvant therapy in the treatment of pre- and post-menopausal patients with breast cancer. One of its known complications is venous thromboembolism. However, arterial thrombosis has been reported rarely. METHODS: A 49-year-old patient with breast cancer had had a total mastectomy 3 years earlier. She was receiving tamoxifen therapy when she developed a sudden onset of pain and numbness of the left foot and calf. An arteriogram showed thrombosis of her tibial arteries. RESULTS: This thrombosis was lysed successfully with urokinase therapy, and tamoxifen therapy was discontinued. At follow-up 4 months later, the patient had normal circulation to both legs. CONCLUSIONS: Patients receiving tamoxifen should be monitored closely for the development of venous or arterial thromboembolism.     

Hybrid inorganic membrane technology shows promise in gas processing

This paper examines how the use of novel hybrid inorganic membrane technology is enabling natural gas processing and the production of high density hydrogen without any impurities.     

Study of heat and mass transfer in indoor conditions for distillation

An indoor simulation study was carried out to evaluate heat and mass transfer relation for a semi-cylindrical metallic (opaque) condensing cover for higher yields at different operating temperatures under free and forced modes of operation. The objective is to design a distillation unit for higher yield for commercialization, particularly in India. Experiments have been conducted for the operating temperature range of 40°C to 80°C in a steady-state condition by using constant temperature bath. Data (temperature and yield) obtained from experimentation have been used to determine the values of coefficient C and n and, consequently, convective as well as evaporative heat transfer coefficients. It is inferred that a higher yield is obtained with an increase of temperature in the forced mode of operation as compared to that in the natural mode of operation due to a fast release of heat from the condensing cover.     

Modeling of non‐linear systems by FWNNs and their intelligent control

By utilizing some of the important properties of wavelets like denoising, compression, multiresolution along with the concepts of fuzzy logic and neural network, two fuzzy wavelet neural networks (FWNNs) are proposed for approximating any arbitrary non‐linear function, hence, identifying a non‐linear system. We have fuzzified the output of DWT block, which receives the given inputs, in the proposed two methods: one using compression property and other using multiresolution property. We present a new type of fuzzy neuron model, each non‐linear synapse of which is characterized by a set of fuzzy implication rules with singleton weights in their consequents. It is shown that noise and disturbance in the reference signal are reduced with wavelets and also the variation of somatic gain, the parameter that controls the slope of the activation function in the neural network, leads to more accurate output. Identification results are found to be accurate and speed of their convergence is fast. Next, we simulate a control system for keeping output at a desired level by using the identified models. Two self‐learning controllers are designed in this simulation. One is a self‐learning fuzzy PI controller and other is a NN controller. Simulation results show that the NN controller is more adaptive and fast. Copyright © 2005 John Wiley & Sons, Ltd.