Do COVID-19 Infections Result in a Different Form of Secondary Hemophagocytic Lymphohistiocytosis

The coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has resulted in significant morbidity and mortality across the world, with no current effective treatments available. Recent studies suggest the possibility of a cytokine storm associated with severe COVID-19, similar to the biochemical profile seen in hemophagocytic lymphohistiocytosis (HLH), raising the question of possible benefits that could be derived from targeted immunosuppression in severe COVID-19 patients. We reviewed the literature regarding the diagnosis and features of HLH, particularly secondary HLH, and aimed to identify gaps in the literature to truly clarify the existence of a COVID-19 associated HLH. Diagnostic criteria such as HScore or HLH-2004 may have suboptimal performance in identifying COVID-19 HLH-like presentations, and criteria such as soluble CD163, NK cell activity, or other novel biomarkers may be more useful in identifying this entity.     

Roles of Key Ion Channels and Transport Proteins in Age-Related Hearing Loss

The auditory system is a fascinating sensory organ that overall, converts sound signals to electrical signals of the nervous system. Initially, sound energy is converted to mechanical energy via amplification processes in the middle ear, followed by transduction of mechanical movements of the oval window into electrochemical signals in the cochlear hair cells, and finally, neural signals travel to the central auditory system, via the auditory division of the 8th cranial nerve. The majority of people above 60 years have some form of age-related hearing loss, also known as presbycusis. However, the biological mechanisms of presbycusis are complex and not yet fully delineated. In the present article, we highlight ion channels and transport proteins, which are integral for the proper functioning of the auditory system, facilitating the diffusion of various ions across auditory structures for signal transduction and processing. Like most other physiological systems, hearing abilities decline with age, hence, it is imperative to fully understand inner ear aging changes, so ion channel functions should be further investigated in the aging cochlea. In this review article, we discuss key various ion channels in the auditory system and how their functions change with age. Understanding the roles of ion channels in auditory processing could enhance the development of potential biotherapies for age-related hearing loss.     

IP Paging Service for Mobile Hosts

In wireless networks, mobile hosts must update the network with their current location in order to get packets delivered. Paging facilitates efficient power management at the mobile host by allowing the host to update the network less frequently at the cost of providing the network with only approximate location information. The network determines the exact location of a mobile host through paging before delivering packets destined to the mobile host. In this paper, we propose the concept of paging as an IP service. IP paging enables a common infrastructure and protocol to support the different wireless interfaces such as CDMA, GPRS, wireless LAN, avoiding the duplication of several application layer paging implementations and the inter-operability issues that exist today. We present the design, implementation, and detailed qualitative and quantitative evaluation, using measurements and simulation, of three IP-based paging protocols for mobile hosts.     

A method of identification of abnormal glow curves in individual monitoring using CaSO4:Dy teflon TLD and hot gas reader

In the present study, a method of identifying abnormal glow curves to electronically screen the glow curves of TL readout is presented. The method is based on the fact that the shape of an abnormal glow curve differs from the shape of a normal one. A few criteria for defining the normal shape of glow curves are arrived at by analysing the glow curves of dosemeters exposed to various doses in laboratory conditions and read at different elapsed time post irradiation. About 300 glow curves of dosemeters used for monthly monitoring were analysed as per these criteria and the effectiveness of the method is observed for total counts as low as 150 μSv equivalent.     

Analysis of flexoelectric response in nanobeams using nonlocal theory of elasticity

This paper is concerned with the derivation of exact solutions for the static responses of simply supported nonlocal flexoelectric nanobeams. Considering both the direct and the converse flexoelectric effects, and employing the nonlocal theory of elasticity, the governing equations and the associated boundary conditions of the beams are derived to obtain the exact solutions for the displacements, nonlocal stresses and the electric potential in the beams. Both the direct and the converse flexoelectric effects are influenced by the nonlocal parameter. Active beams significantly counteract the applied mechanical load by virtue of the converse flexoelectric effect. The normal and the transverse shear deformations in the beams are affected by the converse flexoelectric effect resulting in the coupling of bending and stretching deformations in the beams even if the beams are homogeneous. Because of the consideration of the nonlocal theory of elasticity, the nonlocal stiffness of the beam appears to be less than the classical stiffness of the beam. The nonlocal elasticity does not influence the stresses of the passive beam while the nonlocal stresses in the active beam due to converse flexoeletric effect are less than the local or classical stresses in the active beam. The benchmark results presented here may be useful for verifying the numerical model and experimental results for nonlocal flexoelectric nanobeams. The present study suggests that the flexoelectric nanobeams may be effectively exploited for developing advanced smart nanosensors and nanoactuators. The research work carried out here also conveys that the nonlocal theory of elasticity must be employed for accurate analysis of flexoelectric solids.     

Particulate matter pollution in opencast coal mining areas: a threat to human health and environment

With the increase in depth of mines, the movement and dispersion of particulate matter (PM) are very difficult to predict due to improper ventilation. Insufficient open pit ventilation remains the principal driver for the lack of dispersion and evacuation from mines and ultimately increases the time and amount of exposure to miners. Studies suggest that there is a direct and dependent relationship between the composition and exposure time to PM in mining operations. Furthermore, this paper helps the reader appreciate the need of carrying out studies to understand the nature of the dispersion of PM inside the mines.     

Lipase‐catalysed acidolysis of mango kernel fat with capric acid to obtain medium‐ and long‐chain triacylglycerols

Mango kernel fat (MKF) was blended with capric acid (1:5 mole ratio) and subjected to acidolysis using 1,3 specific lipase Lipozyme IM (Mucor miehei) for different time intervals (30 min to 24 h). The capric acid content increased gradually up to 43.5 mol% with corresponding decrease in stearic acid content (45.7–17.4 mol%). DSC crystallisation thermograms showed a new exothermic peak at lower temperature, and HPLC profile showed new peaks both indicating the formation of new lower melting triglycerides. A decrease in higher melting triglycerides and gradual increase in new triglycerides was observed. Two prominent newly formed triglycerides were characterised by ESI/MS studies and identified as 2‐oleo‐dicaprin (10, 18′, 10) and stearo‐oleo‐caprin (18, 18′, 10). Solid fat content decreased at all temperatures and samples interesterified for 5 h remained liquid at ambient conditions. The modified MKF can increase the food application from MKF in addition to contributing to health benefits of medium‐ and long‐chain triglycerides.