全文获取类型
收费全文 | 229篇 |
免费 | 25篇 |
国内免费 | 1篇 |
专业分类
电工技术 | 2篇 |
化学工业 | 61篇 |
金属工艺 | 7篇 |
机械仪表 | 16篇 |
建筑科学 | 7篇 |
能源动力 | 16篇 |
轻工业 | 31篇 |
水利工程 | 6篇 |
石油天然气 | 1篇 |
无线电 | 22篇 |
一般工业技术 | 37篇 |
冶金工业 | 5篇 |
自动化技术 | 44篇 |
出版年
2023年 | 5篇 |
2022年 | 8篇 |
2021年 | 25篇 |
2020年 | 16篇 |
2019年 | 18篇 |
2018年 | 33篇 |
2017年 | 17篇 |
2016年 | 19篇 |
2015年 | 16篇 |
2014年 | 20篇 |
2013年 | 31篇 |
2012年 | 7篇 |
2011年 | 14篇 |
2010年 | 14篇 |
2009年 | 6篇 |
2008年 | 2篇 |
2007年 | 3篇 |
2006年 | 1篇 |
排序方式: 共有255条查询结果,搜索用时 15 毫秒
51.
Somayeh S. Tarighat Fei Fei Eun Ji Joo Hisham Abdel-Azim Lu Yang Huimin Geng Khuchtumur Bum-Erdene I. Darren Grice Mark von Itzstein Helen Blanchard Nora Heisterkamp 《International journal of molecular sciences》2021,22(22)
Environmentally-mediated drug resistance in B-cell precursor acute lymphoblastic leukemia (BCP-ALL) significantly contributes to relapse. Stromal cells in the bone marrow environment protect leukemia cells by secretion of chemokines as cues for BCP-ALL migration towards, and adhesion to, stroma. Stromal cells and BCP-ALL cells communicate through stromal galectin-3. Here, we investigated the significance of stromal galectin-3 to BCP-ALL cells. We used CRISPR/Cas9 genome editing to ablate galectin-3 in stromal cells and found that galectin-3 is dispensable for steady-state BCP-ALL proliferation and viability. However, efficient leukemia migration and adhesion to stromal cells are significantly dependent on stromal galectin-3. Importantly, the loss of stromal galectin-3 production sensitized BCP-ALL cells to conventional chemotherapy. We therefore tested novel carbohydrate-based small molecule compounds (Cpd14 and Cpd17) with high specificity for galectin-3. Consistent with results obtained using galectin-3-knockout stromal cells, treatment of stromal-BCP-ALL co-cultures inhibited BCP-ALL migration and adhesion. Moreover, these compounds induced anti-leukemic responses in BCP-ALL cells, including a dose-dependent reduction of viability and proliferation, the induction of apoptosis and, importantly, the inhibition of drug resistance. Collectively, these findings indicate galectin-3 regulates BCP-ALL cell responses to chemotherapy through the interactions between leukemia cells and the stroma, and show that a combination of galectin-3 inhibition with conventional drugs can sensitize the leukemia cells to chemotherapy. 相似文献
52.
Somayeh Abazari Saeed Rastegari Shahram Kheirandish 《Journal of Materials Engineering and Performance》2017,26(7):3133-3143
In the present study, Co-W nano-structured alloy coatings are produced on low-carbon steel substrate by means of pulse electrodeposition from a citrate-based bath under different average current densities and duty cycles. The results indicate that the coating deposited under 60% of duty cycle and 1 A/dm2 of average current density exhibit optimum pulse plating conditions with 44.38 wt.% W, 37 nm grain size, and 758 HV microhardness. The effect of heat treatment temperature on microstructure, composition, corrosion behavior, and morphology of amorphous deposited Co-W alloy with 44 wt.% W was investigated. The microhardness of the coating increased to 1052 HV after heat treatment at 600 °C, which is due to the formation of Co3W and CoWO4 phases in the deposit. Furthermore, the coatings heat-treated at 600 °C had lower friction coefficients and better wear resistance under various loads than before heating. 相似文献
53.
The physicochemical composition changes during palm ripening were studied. The activities of invertase and cell wall-modifying enzymes, namely pectin methylesterase (PME), β-galactosidase (β-Gal), endo-1,4-β-d-glucanase (EGase), and cellulase were monitored during growth and ripening of Shahani, Piarom and Deiry cultivars with different textures. Also, we estimated the concentrations of six organic acids by HPLC. Reducing sugars, most of organic acid, pH and TSS increased up to the full-ripe stage of all date types. On the contrary, moisture, macro and microelements and proteins decreased during the same period. Despite a considerable rise in invertase activity (200 units) during ripening of Shahani, no significant trend could be discerned in Deiry cultivar (8 units) at different stages. Our results also showed that cell wall enzymes were increased in activity during ripening and these increases were coincident with fruit softening. Furthermore, our results showed that the composition and the variation of the chemical compositions mainly depended on the cultivar and maturity stage. 相似文献
54.
Isabel Kalinke Peter Kubbutat Somayeh Taghian Dinani Sabine Ambros Mine Ozcelik Ulrich Kulozik 《Comprehensive Reviews in Food Science and Food Safety》2022,21(3):2118-2148
Limitations of microwave processing due to inhomogeneities of power input and energy absorption have been widely described. Over- and underheated product areas influence reproducibility, product quality, and possibly safety. Although a broad range of methods is available for temperature measurement and evaluation of time/temperature effects, none of them is sufficiently able to detect temperature differences and thermally induced effects within the product caused by inhomogeneous heating. The purpose of this review is to critically assess different methods of temperature measurement for their suitability for different microwave applications, namely metallic temperature sensors, thermal imaging, pyrometer measurement, fiber optic sensors, microwave radiometry, magnetic resonance imaging, liquid crystal thermography, thermal paper, and biological and chemical time-temperature indicators. These methods are evaluated according to their advantages and limitations, method characteristics, and potential interference with the electric field. Special attention is given to spatial resolution, accuracy, handling, and purpose of measurement, that is, development work or online production control. Differences of methods and examples of practical application and failure in microwave-assisted food processing are discussed with a special focus on microwave pasteurization and microwave-assisted drying. Based on this assessment, it is suggested that infrared cameras for measuring temperature distribution at the product surface and partially inside the product in combination with a chemical time/temperature indicator (e.g., Maillard reaction, generating heat-induced color variations, depending on local energy absorption) appear to be the most appropriate system for future practical application in microwave food process control, microwave system development, and product design. Reliable detection of inhomogeneous heating is a prerequisite to counteracte inhomogeneity by a targeted adjustment of process and product parameters in microwave applications. 相似文献
55.
56.
57.
58.
Burst is a common pattern in the user's requirements, which suddenly increases the workload of virtual machines (VMs) and reduces the performance and energy efficiency of cloud computing systems (CCS). Virtualization technology with the ability to migrate VMs attempts to solve this problem. By migration, VMs can be dynamically consolidated to the users' requests. Burst temporarily increases the workload. Ignoring this issue will lead to incorrect decisions regarding the migration of VMs. It increases the number of migrations and Service Level Agreement Violations (SLAVs) due to overload. This may cause waste of resources, increase in energy consumption, and misplaced VMs. Therefore, a burst‐aware method for these issues is proposed in this paper. The method consists of two algorithms: one for determining the migration time and the other for the placement of VMs. We use the PlanetLab real dataset and CloudSim simulator to evaluate the performance of the proposed method. The results confirm the advantages of the method regarding performance compared to benchmark methods. 相似文献
59.
Somayeh Behzad 《Journal of Electronic Materials》2018,47(4):2209-2214
Effects of strain on the electronic and optical properties of graphene on monolayer boron nitride (BN) substrate are investigated using first-principle calculations based on density functional theory. Strain-free graphene/BN has a small band gap of 97 meV at the K point. The magnitude of band gap increases with in-plane biaxial strain while it decreases with the perpendicular uniaxial strain. The \( \varepsilon_{2} (\omega ) \) spectrum of graphene/BN bilayer for parallel polarization shows red and blue shifts by applying the in-plane tensile and compressive strains, respectively. Also the positions of peaks in the \( \varepsilon_{2} (\omega ) \) spectrum are not significantly changed under perpendicular strain. The calculated results indicate that graphene on the BN substrate has great potential in microelectronic and optoelectronic applications. 相似文献
60.
Ahmadiyeh Somayeh Rasooli Ali Hosseini Mir Ghasem 《Metallurgical and Materials Transactions A》2020,51(6):3167-3179
Metallurgical and Materials Transactions A - In this study, the electrodeposition parameters were optimized to attain Ni-B alloy coatings with high hardness and corrosion resistance. The optimum... 相似文献