Rotation of polarization axis of injection lasers with viewing direction

It is shown theoretically that in lasers with box modes and polarization determined by facet reflectivity, the axis of polarization rotates with viewing direction. For thin double-heterojunction (DHJ) cavities, the angle ρ between the junction plane and theEfield of the radiation depends on the angles θ and φ in the junction plane and transverse to it,rho approx 10^{-2}thetaphiin degrees. It is suggested that this behavior is a useful test for control of polarization by facet reflection. Measurements show the relation is followed in wide sawed lasers with good box modes prepared from a thin DHJ wafer and in a narrow stripe laser from the same wafer. A second narrow stripe laser from the wafer and a single-heterojunction (SHJ) cavity have no such dependence. Qualitative discussion of the measurements reveals information about polarization and mode properties not previously available.     

Irradiation inactivation of four Salmonella serotypes in orange juices with various turbiditiest

Reconstituted orange juice inoculated with Salmonella Anatum, Salmonella Infantis, Salmonella Newport, or Salmonella Stanley was treated with gamma radiation at 2 degrees C. To determine the relationship between juice antioxidant power and Dgamma (dose required to achieve 90% mortality), juice solids were removed prior to inoculation by centrifugation and/or filtration to create juice preparations of varying turbidity. In unadulterated orange juice, Salmonella Anatum (Dgamma = 0.71 kGy) was significantly more resistant than the other species tested. Salmonella Newport (Dgamma = 0.48 kGy) and Salmonella Infantis (Dgamma = 0.35 kGy) were significantly different, while Salmonella Stanley (Dgamma = 0.38 kGy) was intermediate between the two. Neither the resistance of each isolate nor the pattern of relative resistance among isolates was altered in reduced turbidity juice preparations. Although total antioxidant power was associated with the level of juice solids resuspended in phosphate buffer, antioxidant power was not significantly associated with turbidity in the juice preparations or with Dgamma of any species. The variable resistance to irradiation of the Salmonella isolates suggests this as a more significant factor than turbidity or antioxidant power in designing antimicrobial juice irradiation protocols.     

p53 and K-ras status in duodenal adenomas in familial adenomatous polyposis

BACKGROUND: The genetic alterations in patients with familial adenomatous polyposis (FAP) and duodenal adenomas are poorly characterized when compared with data relating to colorectal tumorigenesis in the same patients. METHODS: Point mutation of the K-ras oncogene and point mutation and overexpression of the TP53 tumour suppressor gene were investigated in 32 duodenal polyps (seven without mucosal pathology, 23 with mildly dysplastic adenomas and two with moderately dysplastic adenomas) from 21 patients with FAP. RESULTS: K-ras mutation, TP53 mutation or positive p53 staining were not found in duodenal polyps without histological abnormality. Of 25 duodenal adenomas, K-ras mutation was found in three (two mildly dysplastic, one moderately dysplastic), 20 showed positive p53 immunostaining, and mutation of the TP53 gene was found in one moderately dysplastic adenoma. p53 protein overexpression in duodenal adenomas was significantly more frequent than mutation of either K-ras or TP53 (P < 0.01). CONCLUSION: p53 dysfunction is a hallmark of duodenal adenomas in patients with FAP. Overexpression may indicate DNA damage and thus an early step in tumorigenesis.     

Measurement of agonist efficacy using an alpha2A-adrenoceptor-Gi1alpha fusion protein

A fusion protein was constructed between the porcine alpha2A-adrenoceptor and a pertussis toxin-insensitive (Cys351Gly) form of the alpha subunit of the G protein Gi1. Addition of agonist ligands to membranes of COS-7 cells transiently transfected to express this construct, and treated with pertussis toxin prior to cell harvest, resulted in stimulation of both high affinity GTPase activity and enhanced binding of [35S]GTPgammaS. By considering the fusion protein as an agonist-activated enzyme and measuring Vmax of GTP hydrolysis a range of agonist ligands displayed varying efficacy in their capacity to activate the receptor-associated G protein with adrenaline = noradrenaline = alpha-methylnoradrenaline > UK14304 > BHT933 > or = xylazine = clonidine. A similar rank order was observed following independent co-expression of the alpha2A-adrenoceptor and Cys351Gly-Gi1alpha. These data demonstrate the utility and applicability of using a receptor-G protein fusion protein approach, in which the stoichiometry of receptor and G protein is fixed at 1:1, to measure and further understand the nature of agonist efficacy.     

ATE应对90nm及以下节点良率问题

正如2007版国际半导体技术蓝图（ITRS）所提到的,自动测试设备（ATE）所面临的最紧迫的技术挑战便是“促进良率提高的测试”,特别是对于90、65、45nm和未来工艺节点上的晶圆工艺和器件良率学习。     

降低测试成本,提高吞吐率

在测试、组装和封装TechXPOT的“成品率管理”分会上,很多与会者展示了降低不断飞升的测试成本的重要性。总的来说,与会者都能就下述观点达成一致,即随着芯片复杂性的不断提高以及器件平均售价（ASP）的不断降低,     

IC CAD中的图形运算算法与实现

熊猫系统是一个基于全定制ASIC,同时能完成半定制ASIC设计的完整的ICCAD系统。GOA(Geometric Operations and Analysis tool)是其中的完成图形算术、逻辑、拓扑运算的工具及软件库。本文将介绍它的作用及其与其它工具的关系,并详细介绍了其算法及我们在α测试和β测试中针对速度和精度要求所做的改进工作。     

A thermal model of friction stir welding applied to Sc-modified Al–Zn–Mg–Cu alloy extrusions

A thermal model of friction stir welding is presented that proposes an energy-based formulation of the Johnson–Cook plasticity model in order to account for heat generation due to plastic deformation. The proposed formulation is derived from an empirical, linear relationship observed between the ratio of the maximum welding temperature to the solidus temperature of the alloy and the welding energy. The thermal model is applied to Sc-modified Al–Zn–Mg–Cu alloy extrusions joined by friction stir welding at 225, 250, 300 and 400 RPM (all other weld parameters held constant). With the incorporation of heat generation due to plastic deformation, the thermal model accurately predicts the maximum weld temperatures and temperature profiles at the higher energy weld conditions, i.e. 300 and 400 RPM. At the lower energy welds (i.e. 225 and 250 RPM) where plastic deformation contributes a larger portion to the total heat generation, the model under-predicts the maximum weld temperatures under the tool shoulder but shows good agreement with the remaining experimental temperature data.