Cellular mechanisms for developmental toxicity of chlorpyrifos: targeting the adenylyl cyclase signaling cascade

Developmental neurotoxicity caused by chlorpyrifos exposure is generally thought to target cholinesterase but chlorpyrifos may also act on cellular intermediates, such as adenylyl cyclase, that serve global functions in the coordination of cell development. In the current study, neonatal rats were exposed to apparently subtoxic doses of chlorpyrifos (no weight loss, no mortality) either on Postnatal Days 1-4 or on Postnatal Days 11-14, and the effects on components of the adenylyl cyclase cascade were evaluated in brain regions that are enriched (forebrain) or sparse (cerebellum) in cholinergic innervation, as well as in a nonneural tissue (heart). In all three, chlorpyrifos evoked deficits in multiple components of the adenylyl cyclase cascade: expression and activity of adenylyl cyclase itself, functioning of G-proteins that link neurotransmitter and hormone receptors to cyclase activity, and expression of neurotransmitter receptors that act through this cascade. Disruption of signaling function was not restricted to transduction of cholinergic signals but rather extended to adrenergic signals as well. In most cases, the adverse effects were not evident during the immediate period of chlorpyrifos administration, but appeared after a delay of several days. These results suggest that chlorpyrifos can affect cell development by altering the activity and reactivity of the adenylyl cyclase signaling cascade, a major control point for trophic regulation of cell differentiation. The effects are not restricted to cholinergic targets, nor even to the central nervous system. Hence, disruption of cell development by chlorpyrifos is likely to be more widespread than previously thought.     

The feature-based posterior crown design in a dental CAD/CAM system

This paper presents a newly developed CAD approach for a quick and accurate design of a dental posterior prosthesis. The approach arises from the basic idea that every human tooth has its own specific features. Based upon the features of the standard posterior tooth, the initial data containing the defined feature points are firstly acquired from the scanned points of the standard tooth. The standard prosthetic profile is thereby formulated using the bicubic Nurbs surface fitting technique. This profile has the two functions of possessing the same features with the patient’s missing posterior tooth, and the adjustability with the feature points and the defined B-spline profile feature curves. For the purpose of the adjustment of the established model, the global and occlusal feature curves are proposed considering the individual patient’s original information. According to these curves, the corresponding standard prosthetic profile is locally adjusted to meet the fit of the global size and occlusal surface. Finally, a close and continuous profile of a posterior crown is generated. Using this design, a posterior prosthesis is successfully manufactured in the computer-aided machining process.     

大朝山水电站碾压混凝土重力坝台阶式溢流面设计

大朝山水电站碾压混凝土重力坝的最大坝高为111m,设计洪水位为899m(500年一遇),此时,表孔下泄的设计流量为9992m3/s,堰顶设计单宽流量为132.7m3(/s·m)。通过多次表孔水工模型试验研究和近三年表孔泄水运行,验证了大朝山水电站碾压混凝土重力坝的表孔采用宽尾墩、台阶式溢流面和戽式消力池联合消能的设计方案是合理可行的,为全段面碾压混凝土重力坝和表孔溢流面的设计开拓了新的思路。     

A 4-MB on-chip L2 cache for a 90-nm 1.6-GHz 64-bit microprocessor

A 4-MB L2 data cache was implemented for a 64-bit 1.6-GHz SPARC(r) RISC microprocessor. Static sense amplifiers were used in the SRAM arrays and for global data repeaters, resulting in robust and flexible timing operation. Elimination of the global clock grid over the SRAM array saves power, enabled by combining the clock information with array select signals. Redundancy was implemented flexibly, with shift circuits outside the main data array for area efficiency. The chip integrates 315 million transistors and uses an 8-metal-layer 90-nm CMOS process.     

广义频率响应函数的鲁棒建模新方法

针对基于非线性谱分析的故障诊断技术的需要,研究了非线性系统的广义频率响应函数的鲁棒在线建模方 法。首先将次元分析算法应用于Volterra级数模型的辨识,并通过对此算法的修正,得到了一种改进的Volterra系统的鲁 棒辨识算法。对其鲁棒性能进行的分析表明,改进算法的鲁棒抗噪性能被明显提高。在此基础上,提出了一种广义频率响 应函数的两步鲁棒建模新方法。仿真实验表明,该方法具有良好的鲁棒收敛性能,能够有效解决GFRF的在线建模问题。     

油罐清洗作业防火安全措施

目前大型原油储罐逐步应用自动机械清洗系统进行清罐作业,而对于容量小、沉积物较少的油罐国内仍采用人工清洗方式进行。分析了油罐人工清洗作业过程时容易引发火灾的原因,并提出相应的预防火灾措施。     

辽河减压渣油中金属铁的赋存与分布特征

考察了辽河减渣在吸附分离、酸性溶液萃取和沥青质轻度降解过程中金属铁的分布和转移情况。结果表明，辽河减渣中有近90％的铁富集在胶质和沥青质中，部分铁以侧链较短的环烷酸盐或酚盐形式存在，部分铁连接在沥青质分子的侧链上，或是被包裹在沥青质大分子中。     

板坯连铸涡流检测钢水液位系统的应用

介绍了新一代RAM型涡流传感钢水液位控制仪在莱钢板坯连铸机上的应用及其效果。     

基于地震道时频分析的地层结构解析原理和方法

 地震时频分析是通过对地震信号采用多种数学变换，实现从时频域角度对信号的局部特征进行分解，剖析信号细微特征所对应的地层结构。在应用地震时频分析技术过程中，人们对于这项技术能否真正有效地解决实际地质问题存在许多争论。本文从时频原理综合分析的角度出发，对地震道时频谱中各种频率特性参数和时频旋回直接转化成对地层结构逐级、分步的解析方法进行了较深入的探讨。研究认为时频分析原理不仅是对地震数据进行特殊数学变换，实现对信号的分解，而且充分利用了地层厚度的调谐效应及岩性调谐效应；时频谱与地质结构特征之间的良好响应关系为地震地质精细解释提供了直观的依据。