Gambling versus Designing: Organizing for the Design of the Probability Space in the Energy Sector

The objective of this paper is to elucidate an organizational process for the design of generic technologies (GTs). While recognizing the success of GTs, the literature on innovation management generally describes their design according to evolutionary strategies featuring multiple and uncertain trials, resulting in the discovery of common features among multiple applications. This random walk depends on multiple market and technological uncertainties that are considered exogenous: as smart as he can be, the ‘gambler’ must play in a given probability space. However, what happens when the innovator is not a gambler but a designer, i.e., when the actor is able to establish new links between previously independent emerging markets and technologies? Formally speaking, the actor designs a new probability space. Building on a case study of two technological development programmes at the French Center for Atomic Energy, we present cases of GTs that correspond to this logic of designing the probability space, i.e. the logic of intentionally designing common features that bridge the gap between a priori heterogeneous applications and technologies. This study provides another example showing that the usual trial‐and‐learning strategy is not the only strategy to design GTs and that these technologies can be designed by intentionally building new interdependences between markets and technologies. Our main result is that building these interdependences requires organizational patterns that correspond to a ‘design of exploration’ phase in which multiple technology suppliers and application providers are involved in designing both the probability space itself and the instruments to explore and benefit from this new space.     

Kolmogorov complexity and combinatorial methods in communication complexity

We introduce a method based on Kolmogorov complexity to prove lower bounds on communication complexity. The intuition behind our technique is close to information theoretic methods.We use Kolmogorov complexity for three different things: first, to give a general lower bound in terms of Kolmogorov mutual information; second, to prove an alternative to Yao’s minmax principle based on Kolmogorov complexity; and finally, to identify hard inputs.We show that our method implies the rectangle and corruption bounds, known to be closely related to the subdistribution bound. We apply our method to the hidden matching problem, a relation introduced to prove an exponential gap between quantum and classical communication. We then show that our method generalizes the VC dimension and shatter coefficient lower bounds. Finally, we compare one-way communication and simultaneous communication in the case of distributional communication complexity and improve the previous known result.     

Circulating Monocyte Subsets and Transcatheter Aortic Valve Replacement

Transcatheter aortic valve replacement (TAVR), as an alternative to open heart surgery, has revolutionized the treatment of severe aortic valve stenosis (AVS), the most common valvular disorder in the elderly. AVS is now considered a form of atherosclerosis and, like the latter, partly of inflammatory origin. Patients with high-grade AVS have a highly disturbed blood flow associated with high levels of shear stress. The immediate reopening of the valve during TAVR leads to a sudden restoration of a normal blood flow hemodynamic. Despite its good prognosis for patients, TAVR remains associated with bleeding or thrombotic postprocedural complications, involving mechanisms that are still poorly understood. Many studies report the close link between blood coagulation and inflammation, termed thromboinflammation, including monocytes as a major actor. The TAVR procedure represents a unique opportunity to study the influence of shear stress on human monocytes, key mediators of inflammation and hemostasis processes. The purpose of this study was to conduct a review of the literature to provide a comprehensive overview of the impact of TAVR on monocyte phenotype and subset repartition and the association of these parameters with the clinical outcomes of patients with severe AVS who underwent TAVR.     

Macroporous calcium phosphate ceramic implants for sustained drug delivery

Limited blood circulation to the skeletal tissue is a major cause of reduced therapeutic effects seen with drugs administered by conventional systemic ways. To resolve this issue and obtain a sufficiently high local concentration to induce therapeutic effects, several implanted drug delivery systems have been developed for hard tissues using biomaterials.We have designed a drug delivery device based on hydroxylapatite (HA) and tested it in vitro using metronidazol and chloramphenicol as model compounds. Porous HA ceramics were prepared with two different shapes (cylindrical and spherical). Known amounts of drugs were introduced inside a drilled hole and sealed with wax. The ceramics were then suspended in stirred distilled water in closed polypropylene vials. Drug release was observed during several weeks.A mathematical model used to describe drug release from HA was elaborated based on the expressions of Fick's laws. The experimental kinetic results could be related to ceramic constitution and to drug localization.     

Easy,Green and Safe Carbonylation Reactions through Zeolite‐Catalyzed Carbon Monoxide Production from Formic Acid

Zeolites with the right shape and acid site density and strength, such as certain ZSM‐5 forms, were able to cleanly decompose formic acid to carbon monoxide (CO), and the latter could be directly used in palladium‐catalyzed carbonylation reactions. A simple two‐reactor system was designed to produce CO conveniently and then further react this gas in a safe way. The two‐reactor system is particularly cheap, easy to set up and use. In addition, the carbonylation conditions without pressure allowed for very efficient CO incorporation, with only 1% of palladium(II) chloride (PdCl₂) and Xantphos.

     

Human Chorionic Gonadotropin and Early Embryogenesis: Review

Human chorionic gonadotropin (hCG) has four major isoforms: classical hCG, hyperglycosylated hCG, free β subunit, and sulphated hCG. Classical hCG is the first molecule synthesized by the embryo. Its RNA is transcribed as early as the eight-cell stage and the blastocyst produces the protein before its implantation. This review synthetizes everything currently known on this multi-effect hormone: hCG levels, angiogenetic activity, immunological actions, and effects on miscarriages and thyroid function.     

Immunologic Effects of Stereotactic Body Radiotherapy in Dogs with Spontaneous Tumors and the Impact of Intratumoral OX40/TLR Agonist Immunotherapy

Stereotactic body radiotherapy (SBRT) is known to induce important immunologic changes within the tumor microenvironment (TME). However, little is known regarding the early immune responses within the TME in the first few weeks following SBRT. Therefore, we used the canine spontaneous tumor model to investigate TME responses to SBRT, and how local injection of immune modulatory antibodies to OX40 and TLR 3/9 agonists might modify those responses. Pet dogs with spontaneous cancers (melanoma, carcinoma, sarcoma, n = 6 per group) were randomized to treatment with either SBRT or SBRT combined with local immunotherapy. Serial tumor biopsies and serum samples were analyzed for immunologic responses. SBRT alone resulted at two weeks after treatment in increased tumor densities of CD3+ T cells, FoxP3+ Tregs, and CD204+ macrophages, and increased expression of genes associated with immunosuppression. The addition of OX40/TLR3/9 immunotherapy to SBRT resulted in local depletion of Tregs and tumor macrophages and reduced Treg-associated gene expression (FoxP3), suppressed macrophage-associated gene expression (IL-8), and suppressed exhausted T cell-associated gene expression (CTLA4). Increased concentrations of IL-7, IL-15, and IL-18 were observed in serum of animals treated with SBRT and immunotherapy, compared to animals treated with SBRT. A paradoxical decrease in the density of effector CD3+ T cells was observed in tumor tissues that received combined SBRT and immunotherapy as compared to animals treated with SBRT only. In summary, these results obtained in a spontaneous large animal cancer model indicate that addition of OX40/TLR immunotherapy to SBRT modifies important immunological effects both locally and systemically.