Is the particle deposition in a cell exposure facility comparable to the lungs? A computer model approach

Abstract

Cell exposure experiments at the air-liquid interface (ALI) are used increasingly as indicators for health effects and for the impact of aerosols on the lung. Thereby the aerosol particles are kept airborne and can deposit on a cell surface area similar to the human respiratory tract (RT). However, geometry and air flow rates of an ALI system deviate considerably from the RT. As the tissue-delivered particle dose to the lungs (TD) can hardly be measured, computer models of particle deposition are used here to mimic both the particle deposition at ALI and in the RT. An ALI exposure setup (VitroCell GmbH) for an airflow rate of 100 cm³ min^?1 is selected, where the particle deposition model has been verified experimentally. For the RT we use the hygroscopic lung deposition model of Ferron et al. (2013 Ferron, G. A., S. Upadhyay, R. Zimmermann, and E. Karg. 2013. Model of the deposition of aerosol particles in the respiratory tract of the rat. II. Hygroscopic particle deposition. J. Aerosol Med. Pulm. Drug Deliv. 26 (2):101–19. doi:10.1089/jamp.2011.0965.[Crossref], [PubMed], [Web of Science ®] , [Google Scholar]). Model runs are performed for the particle deposition and for the deposited particles per surface area in both the ALI and the RT. The results show that the ALI-deposited mass is 1-2 orders of magnitude higher than in the alveolar region, because the surface area of the lung region is substantially larger. A particle size range from 40 to 450 nm is identified, where the ratio of both the deposition in a lung region and the deposition at the ALI varies by a factor less than two. Mean values for this ratio are 31 and 101 for the tracheo-bronchial and the alveolar region, respectively. The same size range is found for the ratio of the deposited particles per surface area in a lung region and at the ALI. For this range the mean surface deposition at the ALI is 23- and 1575-times larger than in the tracheo-bronchial and the alveolar lung region, respectively. The effect is partly compensated by different flow rate and cell size.

Copyright © 2020 American Association for Aerosol Research     

Volatile compounds of original African black and white shea butter from Tchad and Cameroon

Shea butter is used as an edible vegetable fat in many African countries. It can be utilized as a substitute or complete replacement for cocoa butter in various applications and plays an important role in traditional African medicinal practice. Although detection of volatile compounds by solid‐phase micro‐extraction gas‐chromatography mass‐spectroscopy (SPME‐GC‐MS) is a very reliable and reproducible technique, which can be used as an important part of authenticity checking, production monitoring and contamination detection, no published data about volatile compounds of shea butter are available so far. In this investigation, the characteristic volatiles in the headspace of original African shea butter samples were identified by using SPME‐capillary‐GC coupled to a mass selective detector. Almost 100 different volatile components were identified, e.g. fatty acids, saturated and unsaturated aldehydes and ketones, terpenes, and typical Maillard reaction products such as methylfuranes and pyrazines. Furthermore, the samples have been olfactorily evaluated by a panel of professional flavorists and trained analytical chemists. It can be stated that variations in processing conditions of shea butter result in considerable differences in the composition of headspace volatiles, detected by SPME‐GC‐MS and human olfaction.     

The Impact of Serial Solutions’ Summon™ on Information Literacy Instruction: Librarian Perceptions

Web-scale discovery systems, such as Serial Solutions’ Summon? Service, are replacing older federated search technologies as the tool for users to access library resources quickly and easily. The impact of Web-scale discovery systems on instruction is not known. This study of instruction librarian perceptions of Summon's impact on instruction and student information literacy skills is based on a survey. The survey reveals librarians’ ambivalence toward Summon. While some librarians agree that Summon has the potential to change the way librarians teach information literacy skills, it has not been fully integrated into the classroom.     

Validation of GOES and MODIS active fire detection products using ASTER and ETM+ data

In this study we implemented a comprehensive analysis to validate the MODIS and GOES satellite active fire detection products (MOD14 and WFABBA, respectively) and characterize their major sources of omission and commission errors which have important implications for a large community of fire data users. Our analyses were primarily based on the use of 30 m resolution ASTER and ETM+ imagery as our validation data. We found that at the 50% true positive detection probability mark, WFABBA requires four times more active fire area than is necessary for MOD14 to achieve the same probability of detection, despite the 16× factor separating the nominal spatial resolutions of the two products. Approximately 75% and 95% of all fires sampled were omitted by the MOD14 and WFABBA instantaneous products, respectively; whereas an omission error of 38% was obtained for WFABBA when considering the 30-minute interval of the GOES data. Commission errors for MOD14 and WFABBA were found to be similar and highly dependent on the vegetation conditions of the areas imaged, with the larger commission errors (approximately 35%) estimated over regions of active deforestation. Nonetheless, the vast majority (> 80%) of the commission errors were indeed associated with recent burning activity where scars could be visually confirmed in the higher resolution data. Differences in thermal dynamics of vegetated and non-vegetated areas were found to produce a reduction of approximately 50% in the commission errors estimated towards the hours of maximum fire activity (i.e., early-afternoon hours) which coincided with the MODIS/Aqua overpass. Lastly, we demonstrate the potential use of temporal metrics applied to the mid-infrared bands of MODIS and GOES data to reduce the commission errors found with the validation analyses.     

LIVING ON THE EDGE?

Housing estates, satellite cities and other formerly idealistic social housing projects are subject to certain modes of representation that often affirm the notion of centre and periphery. The analysis of two series by German photographer Tobias Zielony shot on the outskirts of Marseille, France (Quartiers Nord, 2003) and Halle, Germany (Ha Neu, 2003) shows that these representations may be challenged. By adopting a particularly individual perspective, Zielony underlines photography’s ability to inspire change in our perception of what might be marginal.     

Sampling methods for shortest vectors,closest vectors and successive minima

We study four problems from the geometry of numbers, the shortest vector problem  (Svp)$\left(\text{<small-caps>Svp</small-caps>}\right)$, the closest vector problem  (Cvp)$\left(\text{<small-caps>Cvp</small-caps>}\right)$, the successive minima problem  (Smp)$\left(\text{<small-caps>Smp</small-caps>}\right)$, and the shortest independent vectors problem   (Sivp$\text{<small-caps>Sivp</small-caps>}$). Extending and generalizing results of Ajtai, Kumar, and Sivakumar we present probabilistic single exponential time algorithms for all four problems for all _?p${?}_p$ norms. The results on Smp$\text{<small-caps>Smp</small-caps>}$ and Sivp$\text{<small-caps>Sivp</small-caps>}$ are new for all norms. The results on Svp$\text{<small-caps>Svp</small-caps>}$ and Cvp$\text{<small-caps>Cvp</small-caps>}$ generalize previous results of Ajtai et al. for the Euclidean _?2${?}_2$ norm to arbitrary _?p${?}_p$ norms. We achieve our results by introducing a new lattice problem, the generalized shortest vector problem   (GSvp$\text{<small-caps>GSvp</small-caps>}$). ¹ We describe a single exponential time algorithm for GSvp$\text{<small-caps>GSvp</small-caps>}$. We also describe polynomial time reductions from Svp,Cvp,Smp$\text{<small-caps>Svp</small-caps>},\text{<small-caps>Cvp</small-caps>},\text{<small-caps>Smp</small-caps>}$, and Sivp$\text{<small-caps>Sivp</small-caps>}$ to GSvp$\text{<small-caps>GSvp</small-caps>}$, establishing single exponential time algorithms for the four classical lattice problems. This approach leads to a unified algorithmic treatment of the lattice problems Svp,Cvp,Smp$\text{<small-caps>Svp</small-caps>},\text{<small-caps>Cvp</small-caps>},\text{<small-caps>Smp</small-caps>}$, and Sivp$\text{<small-caps>Sivp</small-caps>}$.     

Mapping wildfire and clearcut harvest disturbances in boreal forests with Landsat time series data

Information regarding the extent, timing and magnitude of forest disturbance are key inputs required for accurate estimation of the terrestrial carbon balance. Equally important for studying carbon dynamics is the ability to distinguish the cause or type of forest disturbance occurring on the landscape. Wildfire and timber harvesting are common disturbances occurring in boreal forests, with each having differing carbon consequences (i.e., biomass removed, recovery rates). Development of methods to not only map, but distinguish these types of disturbance with satellite data will depend upon an improved understanding of their distinctive spectral properties. In this study, we mapped wildfires and clearcut harvests occurring in a Landsat time series (LTS) acquired in the boreal plains of Saskatchewan, Canada. This highly accurate reference map (kappa = 0.91) depicting the year and cause of historical disturbances was used to determine the spectral and temporal properties needed to accurately classify fire and clearcut disturbances. The results showed that spectral data from the short-wave infrared (SWIR; e.g., Landsat band 5) portion of the electromagnetic spectrum was most effective at separating fires and clearcut harvests possibly due to differences in structure, shadowing, and amounts of exposed soil left behind by the two disturbance types. Although SWIR data acquired 1 year after disturbance enabled the most accurate discrimination of fires and clearcut harvests, good separation (e.g., kappa ≥ 0.80) could still be achieved with Landsat band 5 and other SWIR-based indices 3 to 4 years after disturbance. Conversely, minimal disturbance responses in near infrared-based indices associated with green leaf area (e.g., NDVI) led to unreliably low classification accuracies regardless of time since disturbance. In addition to exploring the spectral and temporal manifestation of forest disturbance types, we also demonstrate how Landsat change maps which attribute cause of disturbance can be used to help elucidate the social, ecological and carbon consequences associated with wildfire and clearcut harvesting in Canadian boreal forests.     

Psychology for the public: A content analysis of Psychology Today..

Surveyed the extent to which Psychology Today (PT) has maintained an empirical basis for its articles and the degree to which psychologists and individuals with doctorates have been responsible for PT articles. Two samples of PT were selected for review by 2 raters (the present authors). Findings indicate that not only have PT articles significantly shifted away from a presentation of empirically based data, but the proportion of articles authored by psychologists, as well as the educational level of authors, has declined, particularly in the last 3 yrs. (4 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved)