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41.
Ping Xiao Jue Wang Lei Fang Zitong Zhao Xiangshi Sun Xiaochen Liu Haiqiang Cao Pengcheng Zhang Dangge Wang Yaping Li 《Advanced functional materials》2021,31(36):2104068
Neoantigen vaccines and adoptive dendritic cell (DC) transfer are major clinical approaches to initiate personalized immunity in cancer patients. However, the immunization efficacy is largely limited by the in vivo trajectory including neoantigens’ access to resident DCs and DCs’ access to lymph nodes (LNs). Herein, an innovative strategy is proposed to improve personalized immunization through neoantigen-loaded nanovaccines synergized with adoptive DC transfer. It is found that it enables selective delivery of neoantigens to resident DCs and macrophages by coating cancer cell membranes onto neoantigen-loaded nanoparticles. In addition, the nanovaccines promote the secretion of chemokine C-C motif ligand 2 (CCL2), CCL3, and C-X-C motif ligand 10 from macrophages, thus potentiating the access of transferred DCs to LNs. This immunization strategy enables coordinated delivery of identified neoantigens and autologous tumor lysate-derived undefined antigens, leading to initiation of antitumor T cell immunity in a personalized manner. It significantly inhibits tumor growth in prophylactic and established mouse tumor models. The findings provide a new vision for potentiating adoptive cell transfer by nanovaccines, which may open the door to a transformative possibility for improving personalized immunization. 相似文献
42.
Jinshuang Wang Luyao Chen Mengdi Chen Yuyang Wu Yinghui Wang Yongsheng Yu Junbin Sun Bing Liu Qiangshan Jing 《Ceramics International》2021,47(16):22965-22975
In this study, the destabilization resistance of Sc2O3 and CeO2 co-stabilized ZrO2 (SCZ) ceramics was tested in Na2SO4 + V2O5 molten salts at 750°C–1100 °C. The phase structure and microstructure evolution of the samples during the hot corrosion testing were analyzed with X-ray diffraction (XRD), Raman spectra, scanning electron microscopy (SEM), energy dispersive X-ray spectrum (EDS), and X-ray photoelectron spectroscopy (XPS). Results showed that the destabilization of SCZ ceramics at 750 °C was the result of the chemical reaction with V2O5 to produce m-ZrO2 and CeVO4, and little ScVO4 was detected in the Sc2O3-rich SCZ ceramics. The primary corrosion products at 900 °C and 1100 °C were CeO2 and m-ZrO2 due to the mineralization effect. The Sc2O3-rich SCZ ceramics exhibited excellent degradation resistance and phase stability owing to the enhanced bond strength and the decreased size misfit between Zr4+ and Sc3+. The destabilization mechanism of SCZ ceramic under hot corrosion was also discussed. 相似文献
43.
N.A. Zhuk M.G. Krzhizhanovskaya N.A. Sekushin V.V. Kharton B.A. Makeev V.A. Belyy R.I. Korolev 《Ceramics International》2021,47(14):19424-19433
The solid solutions based on the pyrochlore-type system Bi2MgNb2-xTaxO9 were formed in the compositional range х = 0–2.0 (Bi1·6Mg0·8Nb1.6-tTatO7.2, t = 0–1.6). The Rietveld method was used to refine the structure for Bi2MgNb2-xTaxO9 (x = 0, 1.0, 2.0). The increasing tantalum content led to the slight decrease in the cubic unit cell parameters from 10.56934 (4) Å for x = 0 and 10.54607 (3) Å for x = 2 (sp.gr. Fd-3m:2). At the same time, tantalum additions suppressed grain growth in the pyrochlore ceramics during sintering and made it possible to obtain materials with an average grain size of 1–2 μm (Bi1·6Mg0·8Ta1·6O7.2). The increase in the Ta5+ concentration led to the decrease in the dielectric permeability from 104 (Bi1·6Mg0·8Nb1·6O7.2) to 20 (Bi1·6Mg0·8Ta1·6O7.2) at room temperature, while the dielectric loss tangent remained lower than 0.002, which is due to the small grain size and the high porosity of the samples. An increase in temperature has practically no effect on the values of the dielectric permittivity in the entire frequency range. The samples have weak through conductivity. The activation energies of electrical conductivity varied in the range of 0.84–1.00 eV, and the less tantalum, the lower the activation energy. The electrical properties of the samples at 200 Hz to 1 MHz are described by the simplest parallel scheme. 相似文献
44.
Li Qian Chen Yan Sun Shikun Zhu Muyuan Xue Jing Gao Zihan Zhao Jinfeng Tang Yihe 《Water Resources Management》2022,36(12):4799-4817
Water Resources Management - Increasing water consumption in agriculture due to global climate change has posed considerable challenges to food security, thus improving the efficiency of water... 相似文献
45.
Multimedia Tools and Applications - In this paper, a hashing based watermarking technique for the protection and authentication of document image is proposed. Message Digest 5 (MD5) hashing is... 相似文献
46.
Celia Nieto Milena A. Vega Eva M. Martín del Valle 《International journal of molecular sciences》2021,22(6)
Ferroptosis is gaining followers as mechanism of selective killing cancer cells in a non-apoptotic manner, and novel nanosystems capable of inducing this iron-dependent death are being increasingly developed. Among them, polydopamine nanoparticles (PDA NPs) are arousing interest, since they have great capability of chelating iron. In this work, PDA NPs were loaded with Fe3+ at different pH values to assess the importance that the pH may have in determining their therapeutic activity and selectivity. In addition, doxorubicin was also loaded to the nanoparticles to achieve a synergist effect. The in vitro assays that were performed with the BT474 and HS5 cell lines showed that, when Fe3+ was adsorbed in PDA NPs at pH values close to which Fe(OH)3 begins to be formed, these nanoparticles had greater antitumor activity and selectivity despite having chelated a smaller amount of Fe3+. Otherwise, it was demonstrated that Fe3+ could be released in the late endo/lysosomes thanks to their acidic pH and their Ca2+ content, and that when Fe3+ was co-transported with doxorubicin, the therapeutic activity of PDA NPs was enhanced. Thus, reported PDA NPs loaded with both Fe3+ and doxorubicin may constitute a good approach to target breast tumors. 相似文献
47.
Scientometrics - Computer-assisted methods and tools can help researchers automate the coding process of literature reviews and accelerate the literature review process. However, existing... 相似文献
48.
Heiba Zein K. Mohamed Mohamed Bakr Farag Noura M. Badawi Ali 《Journal of Materials Science: Materials in Electronics》2022,33(13):10388-10398
Journal of Materials Science: Materials in Electronics - Nano Mn0.95M0.05S (M ≡ Cu, Mg) samples were produced using molten salt solid state reaction method. Rietveld analysis of X-ray... 相似文献
49.
Rudenko A. I. Nishchik A. P. Otrokh E. A. Terekh A. M. 《Journal of Engineering Physics and Thermophysics》2022,95(1):206-212
Journal of Engineering Physics and Thermophysics - Results of investigation into the influence of a corrosion process on thermotechnical characteristics of heat pipes of low-temperature range are... 相似文献
50.
Radiochemistry - Magnetically modified waste bark of the Aegle marmelos tree was prepared by using green synthesis method and was used in a batch system for U(VI) removal from aqueous solution. The... 相似文献