大采高煤层综采工作面采空区自燃\

为研究综采工作面灾害气体的运移弥散规律,分析灾害气体运移过程中峰值体积分数及分布的影响因素,在综采工作面内开展示踪气体(SF₆)现场试验,应用一维对流—弥散模型定量分析示踪气体运移特征,使用粒子群算法(PSO)对数学模型中的巷道平均风速和纵向弥散系数进行最优参数估计。结果表明：综采工作面监测到的示踪气体呈现偏态分布,随着运移距离的增加,示踪气体分布影响区域增大;影响监测点处的示踪气体浓度曲线峰值和波形的主要因素是平均风速,其次是纵向弥散系数。对比模拟与试验测试值可以看出,使用一维对流—弥散模型可以准确描述灾害气体在综采工作面内的弥散运移规律。

     

地下矿山地应力场反演数值模拟研究

掌握岩体初始地应力场,尤其是其三向主应力的大小和方向,是进行地下巷道支护和采场结构参数 优化的基础。根据某铁矿地质资料及矿区内断裂构造,以有限元数值分析为基本手段,提出了考虑矿区 F1、F3、 F4、F9 断层构造运动、岩体自重等多因素的岩体初始地应力场反演思路。采用理论分析、三维地质建模和数值模 拟计算相结合的方法,考虑地层岩性、断层构造等因素,联合使用 Micromine、3DMine 及 Rhino 等几种软件建立矿山 三维地质模型,然后采用 FLAC3D 数值模拟软件对模型进行初始应力场计算平衡,得到初始应力场。该方法可以 较好地满足复杂和极复杂地质条件,特别是深部矿井复杂地质条件的地应力反演分析。     

陶融型白酒正常和退化窖泥细菌群落多样性解析及其理化影响因素

利用高通量测序技术解析陶融型白酒正常窖池和退化窖池窖泥细菌群落多样性及其在窖池中的空间异质性,并通过冗余分析（RDA）影响微生物群落的主要理化因素。结果表明,退化窖池窖泥的含水量（36.78%）、pH值（5.50）及铵态氮含量（23.48 mg/100 g）均低于正常窖池窖泥,而总酸含量（13.00 mg/g）和有效磷含量（27.32 mg/100 g）与之相反。窖泥中细菌群落存在明显的空间异质性。与正常窖池窖泥相比,退化窖池窖泥中主要优势细菌门厚壁菌门（Firmicutes）（64.32%）、拟杆菌门（Bacteroidetes）（12.58%）以及主要优势细菌属己酸菌属（Caproiciproducens）（3.03%）、嗜蛋白菌属（Proteiniphilum）（6.60%）、棒状杆菌属（Caldicoprobacter）（1.06%）的平均相对丰度较低。有效磷、总酸和铵态氮含量可能是影响不同质量窖泥细菌菌群空间分布的主要理化因子。     

Organelle-targeted nanocarriers: specific delivery of liposomal ceramide to mitochondria enhances its cytotoxicity in vitro and in vivo

To further increase the therapeutic activity of drugs known to act on intracellular target sites, in vivo drug delivery approaches must actively mediate the specific delivery of drug molecules to the subcellular site of action. We show here that surface modification of nanocarriers with mitochondriotropic triphenylphosphonium cations facilitates the efficient subcellular delivery of a model drug to mitochondria of mammalian cells and improves its activity in vitro and in vivo.     

Discrete system identification and self-tuning control of dissolved oxygen concentration in a stirred reactor

This work presents the applications of discrete-time system identification and generalized minimum variance (GMV) control of dissolved oxygen (DO) level in a batch bioreactor in which Saccharomyces cerevisiae is produced at aerobic condition. Air flow rate and mixing rate were varied to determine the maximum local liquid phase volumetric mass transfer coefficient (K _L a). Maximum K _L a value was determined at a mixing rate of 600 rpm and air flow rate of 3.4 Lmin⁻¹. For control purpose, manipulated variable was selected as air flow rate due to its effectiveness on the K _L a. To examine the dynamic behavior of the bioreactor, various input signals were utilized as a forcing function and three different model orders were tested. A second0order controlled auto regressive moving average (CARMA) model was used as the process model in the control algorithm and in the system identification step. It is concluded that the ternary input is more suitable than the other input types used in this work for system identification. Recursive least squares method (RLS) was used to determine the model parameters. GMV control results were compared with the traditional PID control results by using performance criteria of IAE and ITAE for different types of DO set point trajectories. DO concentration in the batch bioreactor was controlled more successfully with an adaptive controller structure of GMV than the PID controller with fixed parameters.     

Modified gold surfaces by 6-(ferrocenyl)hexanethiol/dendrimer/gold nanoparticles as a platform for the mediated biosensing applications

An electrochemical biosensor mediated by using 6-(Ferrocenyl) hexanethiol (FcSH) was fabricated by construction of gold nanoparticles (AuNPs) on the surface of polyamidoamine dendrimer (PAMAM) modified gold electrode. Glucose oxidase (GOx) was used as a model enzyme and was immobilized onto the gold surface forming a self assembled monolayer via FcSH and cysteamine. Cyclic voltammetry and amperometry were used for the characterization of electrochemical response towards glucose substrate. Following the optimization of medium pH, enzyme loading, AuNP and FcSH amount, the linear range for the glucose was studied and found as 1.0 to 5.0 mM with the detection limit (LOD) of 0.6 mM according to S/N = 3. Finally, the proposed Au/AuNP/(FcSH + Cyst)/PAMAM/GOx biosensor was successfully applied for the glucose analysis in beverages, and the results were compared with those obtained by HPLC.     

New class of 2,5-di(2-thienyl)pyrrole compounds and novel optical properties of its conducting polymer

New type 2,5-di(2-thienyl)pyrrole derivative namely 4-amino-N-(2,5-di(thiophen-2-yl)-1H-pyrrol-1-yl)benzamide (HKCN) have been synthesized via reaction of 1,4-di(2-thienyl)-1,4-butanedione and p-aminobenzoyl hydrazide. Using hydrazide instead of amine not only increases product yield but also improves properties of the corresponding polymer. Spectroelectrochemical investigations revealed that P(HKCN) is more stable and it has lowest band gap and better long-term stability compared with other SNS derivatives. Chronoamperometry experiment showed that P(HKCN) polymer film has excellent redox stability, moderate switching time and high optical contrast. Electrochemical copolymerization of HKCN with EDOT was performed in DCM/TBP₆ solution for different feed ratios of monomers. We describe a proposal to determination copolymer composition by means of the optical properties of conducting copolymers.     

Synthesis and characterization of highly conductive poly(indole-4-aminoquinaldine) copolymer

Conductive polymers with good conductivity and large surface area are used as N-precursor materials for N-doped carbon-based catalysts and increase the catalytic activity of the electrode. Therefore, synthesis of the novel highly conductive polymer is an essential issue. This study reports that the synthesis of a novel copolymer is called poly(indole-4-aminoquinaldine) successfully achieved both chemically and electrochemically. The effect of scan rate, scan number, monomer concentration, and solvent on the polymerization process was investigated, and hereby the optimum synthesis conditions for the copolymer were determined. Under optimum conditions, the polyindole was also synthesized electrochemically and properties of polyindole compared to poly(indole-4-aminoquinaldine). The electrochemical characterization was investigated by cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS). The electrical conductivity of the poly(indole-4-aminoquinaldine) and polyindole was measured using a four-point probe technique as 6 S/cm and 1?×?10^–2 S/cm, respectively. Additionally, bandgap of copolymer and polyindole was found to be 3.10 and 3.18 eV, respectively. The structural, thermal, and morphological analysis of poly(indole-4-aminoquinaldine) and polyindole were carried out with UV–Vis Spectroscopy, Fourier-transform infrared spectroscopy (FT-IR), thermal gravimetric analysis (TGA), X-ray diffraction (XRD), elemental mapping, scan electron microscopy (SEM), and energy-dispersive X-ray analyzer (EDX) techniques. The novel copolymer synthesized in this study has high thermal stability and high electrochemical activity as well as high conductivity.

     

离子刻蚀尼龙1010样品的电镜研究

研究了扫描电镜观察用尼龙１０１０样品的离子刻蚀条件，观察到尼龙１０１０正环状球晶的晶片结构为中心放射生长，晶片扭曲、支化。     

Ni and Cu incorporated mesoporous nanocomposite catalytic materials

Nickel and copper incorporated MCM-41-like mesoporous nanocomposite materials prepared by the direct hydrothermal synthesis and the impregnation procedures showed highly attractive pore structure and surface area results for catalytic applications. The XRD patterns showed that characteristic MCM-41 structure was preserved for the materials synthesized following an impregnation procedure before the calcination step. The surface area of the Cu impregnated material with a quite high Cu/Si atomic ratio (0.19) was 631 m2/g. Very narrow pore size distributions with an average pore diameter of about 2.7 nm were obtained as a result of plugging of some of the smaller pores by Cu nanoballs. For lower metal to Si ratios (for instance for Ni/Si = 0.06) much higher surface area values (1130 m2/g) were obtained. In the case of nanocomposite materials synthesized by the direct hydrothermal route, MCM-41 structure was not destroyed for samples containing metal to Si atomic ratios as high as 0.12. In the case of materials containing Cu/Si and Ni/Si ratios over 0.2 wider pore size distributions and some decrease of surface area were observed.