Oriented Growth of Gold Nanowires on MoS2

Layered 2D materials serve as a new class of substrates for templated synthesis of various nanomaterials even with highly dissimilar crystal structures; thus overcoming the lattice constraints of conventional epitaxial processes. Here, molybdenum disulfide (MoS₂) is used as a prototypical model substrate for oriented growth of in‐plane Au nanowires (NWs) despite the nearly 8% lattice mismatch between MoS₂ and Au. Au NWs on the MoS₂ surface are oriented along three symmetrically equivalent directions within the substrate arising from the strong Au–S binding that templates the oriented growth. The kinetics of the growth process are explored through experiments and modeling. Strong charge transfer is observed between Au NWs and MoS₂, resulting in degenerate p‐doping of MoS₂.     

Impact of temperature and concentration dispersion on the physiology of blood nanofluid: links to atherosclerosis

A theoretical model of blood-silver nanofluid flow through an \(\omega \)-shaped tapered stenotic artery in the presence of a catheter is understood in detail. The rheology of the blood is considered as that of a micro-polar fluid. Suspension of the silver nano-particles in the micro-polar fluid is proposed to investigate the temperature and concentration dispersion from the immersed temperature-sensitive drug-coated nano-particles. The effects of velocity discontinuity at the arterial wall in the stenotic and non-stenotic regions are considered. The outer surface of the catheter is layered with the temperature-sensitive, drug-coated nano-particles. The resulting mathematical formulation involving the coupled non-linear momentum, temperature and concentration equations is solved using the Homotopy Perturbation Method. The efficiency and convergence of the method to the modelled equations are discussed in detail. The consequent effects of the fluid and geometric parameters on pressure drop, flow rate, impedance and wall shear stress of the fluid flow are computed. It is noticed that the high volume fraction of the nano-particles in the blood results in high flow velocity, contributing to secondary flow regions, thus resulting in higher shear stress. Such high volume fraction of the nano-particle may lead to the pathological disorder called aneurysm. This physical model has an important application of drug delivery in biomedical and pharmaceutical industry to prevent obstructions in arteries. Further, the results obtained could be very useful in the manufacturing of related artificial devices.     

简单的通断检测器可装入衬衫兜内

本设计实例描述了方便的有两种工作模式的通断检测器这种检测器在两个探针间检测到通路时会发出声响．在检测到断路时也会发出声音。后一功能可用来检测不连续的线缆断开。响应必须足够快以允许在100个针脚间试测探针，并迅速找到通路针脚。这种检测器也可检查到两个导体间的微法级或较大的电容。     

The Effects of Prodrug Size and a Carbonyl Linker on l-Type Amino Acid Transporter 1-Targeted Cellular and Brain Uptake

The l -type amino acid transporter 1 (LAT1, SLC7A5) imports dietary amino acids and amino acid drugs (e. g., l -DOPA) into the brain, and plays a role in cancer metabolism. Though there have been numerous reports of LAT1-targeted amino acid-drug conjugates (prodrugs), identifying the structural determinants to enhance substrate activity has been challenging. In this work, we investigated the position and orientation of a carbonyl group in linking hydrophobic moieties including the anti-inflammatory drug ketoprofen to l -tyrosine and l -phenylalanine. We found that esters of meta-carboxyl l -phenylalanine had better LAT1 transport rates than the corresponding acylated l -tyrosine analogues. However, as the size of the hydrophobic moiety increased, we observed a decrease in LAT1 transport rate with a concomitant increase in potency of inhibition. Our results have important implications for designing amino acid prodrugs that target LAT1 at the blood-brain barrier or on cancer cells.