Parameter estimation from observations of first-passage times of the Ornstein–Uhlenbeck process and the Feller process

Renewal point processes show up in many different fields of science and engineering. In some cases the renewal points become the only observable parts of an anticipated hidden random variation of some physical quantity. The hypothesis might be that a hidden random process originating from zero or some other low value only becomes visible at the time of first crossing of some given value level, and that the process is restarted from scratch immediately after the level crossing. It might then be of interest to reveal the defining properties of this hidden process from a sample of observed first-passage times. In this paper the hidden process is first anticipated as a non-stationary Ornstein–Uhlenbeck (OU) process with unknown parameters that have to be estimated only by use of the information contained in a sample of first-passage times. The estimation method is a direct application of the Fortet integral equation of the OU process. A non-stationary Feller process is considered subsequently. As the OU process, the Feller process has a known transition probability distribution that allows the formulation of the integral equation. The described integral equation estimation method also provides a subjective graphical test of the applicability of the OU process or the Feller process when applied to a reasonably large sample of observed first-passage data.

These non-stationary processes have several applications in biomedical research, for example as idealized models of the neuron membrane potential. When the potential reaches a certain threshold the neuron fires, whereupon the potential drops to a fixed initial value, from where it continuously builds up again until the next firing. Also in civil engineering there are hidden random phenomena such as internal cracking or corrosion that after some random time break through to the material surface and become observable. However, the OU process has as a model of physical phenomena the defect of not being bounded to the negative side. This defect is not present for the Feller process, which therefore may provide a useful modeling alternative to the OU process.     

Salinity tolerance of the invasive round goby: Experimental implications for seawater ballast exchange and spread to North American estuaries

The Eurasian round goby (Neogobius melanostomus) invaded the freshwater North American Great Lakes in ~ 1990 via accidental introduction from ballast water discharge. Its genotypes in the Great Lakes traced to estuaries in the northern Black Sea, where the round goby flourishes in a variety of salinities to 22 parts per thousand (ppt). To prevent further introductions, U.S. and Canadian Coast Guard regulations now require that vessels exchange ballast water at sea before entering the Great Lakes. Since salinity tolerance of the invasive round goby population is poorly understood, we tested 230 laboratory-acclimated fish in three experimental scenarios: (1) rapid salinity increases (0–40 ppt), simulating ballast water exchange, (2) step-wise salinity increases, as during estuarine tidal fluxes or migration from fresh to saltwater, and (3) long-term survivorship and growth (to 4 months) at acclimated salinities. Almost all gobies survived experiments at 0–20 ppt, whereas none survived ≥ 30 ppt, and at 25 ppt only 15% withstood rapid changes and 30% survived step-wise increases. Ventilation frequencies were lowest at 10–15 ppt in step-wise experiments, in conditions that were near isotonic with fish internal plasma concentrations, reflecting lower energy expenditure for osmoregulation. Growth rates appeared greatest at 5–10 ppt, congruent with the larger sizes reached by gobies in Eurasian brackish waters. Thus, we predict that the Great Lakes round goby would thrive in brackish water estuaries along North American coasts, if introduced. However, oceanic salinities appear fatal to the invasive round goby, which likely cannot withstand complete seawater ballast exchanges or oceanic habitats.     

Human–computer interaction viewed as pseudo-communication

Semiotics is considered fundamental to an understanding of human–computer interaction, and of all computer artifacts. Informatics should therefore be viewed as technical semiotics (or semiotics engineering). In particular, interaction between human and computer is characterized by features of communication, a sort of communication, however, that lacks decisive communicative features. It must be identified as a process of pseudo-communication. Interaction is viewed as the coupling of two autonomous processes: a sign process (carried out by the human user) and a signal process (carried out by the computer). Software appears as a semiotic entity in a duplicate way: calculated and calculating, i.e. both as a result and agent of calculations. This dialectics characterizes the class of signs on the computer medium. Problems of software design (functionality and usability design) are specific problems of the coupling of sign and signal processes.     

Validity of alternative self-report indices of smoking among adolescents.

The convergent validity of popularly used open-ended and closed-ended self-report measures of smoking was examined. Carbon monoxide (CO) samples were obtained from 11th-grade Canadian students as an independent method of assessing recent smoking. In addition to CO, 5 known psychosocial correlates of smoking (attitude, subjective norm, risk taking, best friend's smoking, and other friends' smoking) were used to estimate convergence with the self-report smoking indices. Results indicate that both simple closed-ended scales, with only a few response options, and more continuous, open-ended measures performed about equally as well as correlates of CO and the psychosocial measures, but only if the open-ended scales were subjected to a normalizing transformation to optimize their convergence. After this transformation was performed, convergence depended more on the time-span covered by the self-report indices than on the open-ended/closed-ended distinction. Implications of these results for different assessment goals were discussed. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Changes in energy balance following smoking cessation and resumption of smoking in women.

Caloric intake, resting metabolic rate (RMR), leisure-time physical activity, and sensitivity and preference for sweet taste were prospectively examined in 7 female smokers across 3 weeks during periods of normal smoking (Week 1), complete cessation (Week 2), and resumption of smoking (Week 3). Energy balance changed significantly across weeks, as caloric intake increased (largely as a result of alcohol consumption) and RMR decreased during cessation, followed by decreased caloric intake and increased RMR with resumption of smoking. Activity and taste sensitivity and preference remained unchanged. Smoking cessation may thus cause rapid change in energy balance, which is quickly reversed on resumption of smoking. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Influence of the Gas Atmosphere on the Composition and Phase Development of Polymer-Derived SiOC-Ceramics

Silicon oxycarbide (SiOC)-based ceramics were synthesized by pyrolysis of a commercial polysiloxane containing MoSi₂ and ceramic filler particles. The influence of different gas atmospheres on the chemical composition and on the phase formation of the filled Si–O–C ceramic during the pyrolysis process up to elevated temperatures of above 1200°C has been studied. The pyrolysis gas composition in the furnace during pyrolysis was measured with an in situ gas analyzer. Both the core and the surface of bulk samples were investigated with respect to composition in order to take the changes on the rim area of the specimens into account. The influence of hydrogen gas on the compositional gradient of the resulting ceramic material was derived from samples investigated by polarization microscopy, X-ray diffraction (XRD), and micro-XRD (μ-XRD).     

Selbstbestimmung und Selbstverständnis – Themenschwerpunkte im Umgang mit der Patientenverfügung

Ohne Zusammenfassung     

Potent Inhibition of Acid Sphingomyelinase by Phosphoinositide Analogues

The different mammalian sphingomyelinases are involved in cell regulation, apoptosis and inflammatory events. Recent reports suggest pharmacological potential especially for inhibitors of the acid sphingomyelinase. Phosphatidyl inositol‐3,5bisphosphate (PtdIns3,5P₂) is the most potent selective acid sphingomyelinase inhibitor known to date. In the present study, we synthesized analogues of PtdIns3,5P₂ for initial structure–activity‐relationship (SAR) studies. We identified an inhibitor that is easy to synthesize, that has superior chemical and biophysical properties when compared to PtdIns3,5P₂ and that should be stable against virtually all phospholipases. Last but not least, the new inhibitor partially protected cells from dexamethasone‐induced cell death.