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1.
Cheng-Hsiung Lid Shou-Chiung Chen Yung-Chi Lee Theodore D. Sokoloski Ming-Thau Sheu 《Drug development and industrial pharmacy》1994,20(11):1911-1922
Polyvinylpyrrolidone (PVP) in aqueous solution was used as a binding agent in a fluidized-bed system to agglomerate acetaminophen powder into directly compressible granules. It was found that a minimal amount of 5% w/w PVP in a concentration of 7.5% w/v or less was needed to produce granules with an acceptable flow and the corresponding tablets having enough hardness without capping. There was a strong correlation between the time for 80% dissolved (T80) and the logarithm of granule volume-surface mean diameter. A directly compressible acetaminophen composition to manufacture tablets having a T80 value less than 30 min can be prepared simply by adding an appropriate amount of disintegrant (crospovidone, sodium starch glycolate, or pregelatinized starch) to the agglomerated granules. 相似文献
2.
Gong S.S. Burnham M.E. Theodore N.D. Schroder D.K. 《Electron Devices, IEEE Transactions on》1993,40(7):1251-1257
Electrical time-to-breakdown (TTB) measurements have shown the charge to breakdown Q bd of gate oxide capacitors fabricated on n-type well (n-well) substrates always to be higher than that of capacitors on p-type well (p-well) substrates on the same wafer when both are biased into accumulation under normal test conditions. Here the authors correlate the higher n-well Q bd to smooth capacitor oxide/substrate interfaces and minimized grain boundary cusps at the poly-Si gate/oxide interfaces, confirming that Fowler-Nordheim tunneling is the dominant current conduction mechanisms through the oxide. They correlate higher Q bd to higher barrier height for a given substrate type and observe that the slope of the barrier height versus temperature plot is lower for both p-well and n-well cases with electrons tunneling from the silicon substrate. This is attributed to surface roughness at the poly-Si gate/SiO2 interface. A poly-Si gate deposition and annealing process with clean, smooth oxide/substrate interfaces will improve the p-well breakdown characteristics and allow higher Q bd to be achieved 相似文献
3.
Theodore Sussman Klaus-Jurgen Bathe 《International journal for numerical methods in engineering》1985,21(4):763-774
We derive a closed-form expression for the change in the variational indicator of a finite element mesh with respect to perturbations in nodal point co-ordinates. The expression is evaluated very effectively from standard finite element data obtained in one solution, and may be easily programmed as part of a general finite element code. We present the derivation for two- and three-dimensional isoparametric elements used in linear and nonlincar elasticity. The expression has practical applications in the computation of stress intensity factors in fracture mechanics and in the determination of the ‘optimal’ mesh with a given element-node connectivity. We demonstrate both applications by accurately determining the stress intensity factor of a Mode I crack using a finite element mesh which was improved using mesh optimization. 相似文献
4.
Evaggelia D. Tzika Vassiliki Papadimitriou Theodore G. Sotiroudis Aristotelis Xenakis 《European Journal of Lipid Science and Technology》2008,110(2):149-157
The autoxidation at alkaline pH and enzymatic oxidation by mushroom tyrosinase of oleuropein, the dominant biophenol present in the fruits and leaves of Olea europea, was followed by both electron paramagnetic resonance (EPR) and absorption spectroscopy. For comparison, the same oxidation processes were applied to 4‐methylcatechol, a simple polyphenol present in olive mill wastewaters. EPR spectra of stable o‐semiquinone radicals produced during autoxidation at pH 12 and short‐lived o‐semiquinone free radicals produced during autoxidation at pH 9.0 or tyrosinase action and stabilized by chelation with a diamagnetic metal ion (Mg2+) were recorded for both polyphenols, and the corresponding hyperfine splitting constants were determined. The UV‐Vis spectral characteristics of the oxidation of polyphenols were highly dependent on the type of polyphenol, oxidant type and the pH of the reaction. The kinetic behavior of tyrosinase in the presence of oleuropein and 4‐methylcatechol was followed by recording spectral changes at 400 nm (absorption maximum) over time. The tysosinase activity with oleuropein showed a pronounced pH optimum at pH 6.5 and a minor one around pH 8. From the data analysis of the initial rate at pH 6.5, the kinetic parameters Km = 0.34 ± 0.03 mM and Vmax = 0.029 ± 0.002 ΔA400 min–1 were determined for oleuropein. 相似文献
5.
Poornima Balakrishna Shivakumar Raman Theodore B. Trafalis Budi Santosa 《The International Journal of Advanced Manufacturing Technology》2008,35(9-10):916-923
Several methods have been investigated to determine the deviation of manufactured spherical parts from ideal geometry. One of the most popular is the least squares technique, which is still widely employed in coordinate measuring machines used by industries. The least squares algorithm is optimal under the assumption that the data set is very large and has the inherent disadvantage of overestimating the minimum tolerance zone, resulting sometimes in the rejection of good parts. In addition, it requires that the data be distributed normally. The support vector regression approach alleviates the necessity for these assumptions. While most fitting algorithms in practice today require that the sampled data accurately represent the surface being inspected, support vector regression provides a generalization over the surface. We describe how the concepts of support vector regression can be applied to the determination of tolerance zones of nonlinear surfaces; to demonstrate the unique potential of support vector machine algorithms in the area of coordinate metrology. In specific, we address part quality inspection of spherical geometries. 相似文献
6.
7.
Conventional random access memories are capable only of writing data into and reading data from the storage location corresponding to a given address. The availability of VLSI circuits containing hundreds of thousands of switching devices, however, has recently made practical the implementation of active memory chips capable of performing a range of complex operations on their stored data. Such designs are characterized by the extensive intermingling of processing and memory resources within a single chip to achieve the rapid and cost-effective parallel execution of operations relevant to such tasks as image processing, computer graphics, artificial intelligence, and database management.This paper presents a brief survey of a number of active memory chips that have been implemented or proposed, along with a more detailed examination of a particular active memory circuit, the NON-VON 3 primary processing subsystem chip.This research was supported in part by the Defense Advanced Research Projects Agency, under contract N00039-84-C-0165, in part by the New York Center for Advanced Technology in Computers and Information Systems at Columbia University, and in part by an IBM Faculty Development Award. 相似文献
8.
Theodore Perlstein Abner Eisner Waldo C. Ault 《Journal of the American Oil Chemists' Society》1966,43(6):380-382
Methyl oleate and methyl linoleate were converted to conjugated dienes and trienes, respectively, by selecting and modifying
the conventional procedures usually applied to the generation and characterization of fatty hydroperoxides. Conditions have
been studied in the laboratory for: (a) the optimum production of hydroperoxides with a minimum of by-products, (b) the effective
separation and concentration of the resulting hydroperoxide, (c) the economic reduction of the hydroperoxide mixture, (d)
simple dehydration of the reduced product, and, (e) recovery of the resulting polyene-rich material. If the processing sequence
is halted after the reduction step, the resulting product,is a mixture of allylic hydroxy monoene or diene methyl esters.
Our investigations have been extended to include studies on the methyl esters of commercial oleic acid and the mixture of
methyl esters resulting from alcoholysis of lard oil. Products containing 20–25% conjugated diene and lesser proportions of
conjugated triene were obtained.
Presented at the AOCS Meeting, Houston, April 1965.
E. Utiliz, Res. Dev. Div., ARS, USDA. 相似文献
9.
Santosh K. Verma Zhe Zhao Theodore K. Courtney Wen-Ruey Chang David A. Lombardi Yueng-Hsiang Huang 《Ergonomics》2014,57(12):1919-1926
Several studies have indicated that slip-resistant shoes may have a positive effect on reducing the risk of slips and falls, a leading cause of injury at work. Few studies, however, have examined how duration of shoe usage affects their slip-resistance properties. This study examined the association between the duration of slip-resistant shoes usage and the self-reported rate of slipping in limited-service restaurant workers. A total of 475 workers from 36 limited-service restaurants in the USA were recruited to participate in a 12-week prospective study of workplace slipping. Of the 475 participants, 83 reported changing to a new pair of shoes at least once during the 12-week follow-up. The results show that slip-resistant shoes worn for less than six months were moderately more effective than those worn for more than six months. Changing to a new pair of shoes among those wearing slip-resistant shoes at baseline was associated with a 55% reduction in the rate of slipping (RR = 0.45, 95% CI = 0.23–0.89). Further research is needed to develop criteria for the replacement of slip-resistant shoes.
Practitioner Summary: The duration of usage impacts the slip-resistance properties of slip-resistant shoes. Slip-resistant shoes worn for less than six months were moderately more effective in reducing slips than slip-resistant shoes worn for more than six months. Shoe use policies should not only encourage or require their use but also include guidance on replacing slip-resistant shoes at regular intervals. 相似文献
10.
Xiaoying Wu Dimitri Theodoratos Stefanos Souldatos Theodore Dalamagas Timos Sellis 《World Wide Web》2010,13(4):441-474
Finding the occurrences of structural patterns in XML data is a key operation in XML query processing. Existing algorithms
for this operation focus almost exclusively on path patterns or tree patterns. Current applications of XML require querying
of data whose structure is complex or is not fully known to the user, or integrating XML data sources with different structures.
These applications have motivated recently the introduction of query languages that allow a partial specification of path
patterns in a query. In this paper, we consider partial path queries, a generalization of path pattern queries, and we focus
on their efficient evaluation under the indexed streaming evaluation model. Our approach explicitly deals with repeated labels
(that is, multiple occurrences of the same label in a query). We show that partial path queries can be represented as rooted
dags for which a topological ordering of the nodes exists. We present three algorithms for the efficient evaluation of these
queries. The first one exploits a structural summary of data to generate a set of path patterns that together are equivalent
to a partial path query. To evaluate these path patterns, we extend a previous algorithm for path-pattern queries so that
it can work on path patterns with repeated labels. The second one extracts a spanning tree from the query dag, uses a stack-based
algorithm to find the matches of the root-to-leaf paths in the tree, and merge-joins the matches to compute the answer. Finally,
the third one exploits multiple pointers of stack entries and a topological ordering of the query dag to apply a stack-based
holistic technique. We analyze our algorithms and perform extensive experimental evaluations. Our experimental results show
that the holistic algorithm outperforms the other ones. Our approaches are the first ones to efficiently evaluate this class
of queries in the indexed streaming model. 相似文献