Increased concentrations of octachlorodibenzo-p-dioxin in cases with breast cancer--results from a case-control study

Organochlorines are persistent and highly lipophilic environmental contaminants which bioaccumulate in the food chain. Some of these chemicals, 2,2-bis(p-chlorophenyl)-1,1,1-trichloroethane (DDT) and polychlorinated biphenyls (PCBs), have been suggested to be of significance in the aetiology of breast cancer. 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is an anti-oestrogen in animal studies and should be thus lower the risk of breast cancer. The other isomers of polychlorinated dibenzo-p-dioxins (PCDDs) or the chemically related polychlorinated dibenzofurans (PCDFs) have not been tested regarding carcinogenesis of the breast. The purpose of this study was to investigate whether PCDDs or PCDFs influence the risk for breast cancer. Consecutive patients who underwent surgery for a breast disease between 1993 and 1995 were recruited for the study. Cases were 22 patients with infiltrative breast cancer and controls were 19 patients operated for a benign breast disease during the same time period. Approximately 10 g of breast tissue free from tumour was taken from the specimen and frozen until analysis. Fat was extracted, cleaned and analysed with a high-resolution gas chromatograph coupled to a high-resolution mass spectrometer. Median concentrations of octachlorinated dibenzo-p-dioxin (OCDD) were 598 (170-14,880) and 396 (103-1,847) pg/g lipid in the cases and in the controls, respectively. In a multivariate logistic regression analysis controlling for other risk factors for breast cancer increased odds ratio (OR) was obtained for OCDD: 401-1000 pg/g lipid yielded OR 3.8, 95% confidence interval (CI) 0.4-39, > 1000 pg/g lipid gave OR 5.2, CI 0.4-72. When the lipid OCDD variable was examined as a continuous risk factor there was a 1.09 (9%), CI 0.95-1.25, increase in the adjusted OR for breast cancer per 100 unit (pg/g lipid) increase in OCDD. No differences were found between cases and controls for the other six tested PCDDs. Mean concentration of TCDD was in the cases 3.6 (1.0-7.9) and in the controls 3.3 (1.1-6.3) pg/g lipid. For PCDFs no significant differences were found between cases and controls. The results were not changed if oestrogen or progesterone receptor status, S-phase fraction and DNA ploidy were considered. Breast tissue concentration of OCDD was increased in cancer patients, whereas the concentrations of other PCDDs and PCDFs were equal in cases and controls.     

The regularization ofNB-scheme in differential games

The optimality principles in non-zero sum differential games and multicriterial control problems taken from the corresponding static (simultaneous) game theory are usually dynamic unstable (time inconsistent), thus their use becomes questionable if special regularization attempts are not made. This important aspect was first considered in [1], but also in the earlier paper of Strotz [7] this was shown for a special control problem with discount payoff. We have shown in [2] that many of the known procedures (excluding those based on scalarization of the payoff vector), of selecting of a special Pareto-optimal solution from the set of all Pareto-optimal solutions are dynamic unstable (time-inconsistent) and therefore the regularization procedures leading to the dynamic stable optimality principles are purposed [3]. It turns out that also in the Nash [4] bargaining process the regularization attempt can be made by constructng a special equation for the conflict point. The idea of the method is closely connected with the paper [5]. The special attention to the time-consistency problem is given also in the recent publications [6,8].This paper is financially supported by Russian Fundamental Research Foundation (project N 93-011-1714).     

TQM implementation in hospitals

This paper discusses the essential elements for successful Total Quality Management (TQM) implementation in hospital, and the challenges that occur with such implementation. Guidelines for this implementation are provided to show how TQM tools can be used effectively in hospitals.     

Deformation and fracture of glass bead/ CTBN-rubber/epoxy composites

Carboxyl-terminated butadiene-acrylonitrile-rubber decreases modulus and yield stress of the studied epoxy but increases fracture toughness. The addition of glass bead compensates for the loss in modulus but has little effect on yield stress. However, it significantly contributes to the fracture toughness by providing additional mechanisms for toughening of both the unmodified and rubber-modified epoxy. For the toughened epoxies studied, fracture surfaces gave only limited information on fracture mechanisms since significant energy absorption also occurs in the material below the fracture surface. Suggestions for suitable material compositions for fiber composite matrices are given.     

Correlation of the leakage current and charge pumping in silicon oninsulator gate-controlled diodes

The leakage and charge pumping currents were measured in gate-controlled MOS p-i-n diodes fabricated on thin SIMOX substrates. The efficiencies of the techniques as well as their complementary features are analyzed for various experimental conditions. The interface properties of device-grade SIMOX wafers are characterized and shown to be compatible with VLSI requirements. Special interface coupling effects, which occur only in fully depleted SOI devices and modify the conventional signature of charge pumping and leakage current, are thoroughly investigated     

Optical fiber solitons, their properties and uses

The history and mathematical formulation of solutions are briefly reviewed. Solitons of the nonlinear Schrodinger equation are studied in greater detail because they describe nonlinear pulse propagation on dispersive optical fibers. The proposal by A. Hasegawa and the experiments of L.F. Mollenauer on long distance soliton propagation for use in repeaterless transoceanic fiber transmission cables are described. In 1986, limitations on the distance that can be spanned by a repeaterless link for a given bit rate were shown to exist. It has been shown recently that by proper design these limitations can be overcome, so that newer transoceanic cable designs are likely to utilize solitons. The special properties of solitons make them particularly suited for all optical switching and logic operations. Some recent experiments with such switches are described     

Modeling and analysis of vias in multilayered integrated circuits

A method for modeling and analyzing vias the multilayered integrated circuits is presented. The model is based on microwave network theory. The whole via structure is divided into cascaded subnetworks, including a vertical via passing through different layers and transitions from the microstrip line and/or striplines to the vertical via. The parameters of each subnetwork are obtained from electromagnetic field analysis. Numerical results in the frequency domain and the time domain are presented. Validation of the model has been carried out by both measurements and finite-difference-time-domain (FDTD) modeling. The results show good agreement with the measurements in the frequency range for which the components of the experimental model are within specification. The time domain simulation results also agree well with the FDTD results     

Comment and discussion on digital processing of PD pulses

Some of the more salient aspects of the digital processing technology of PD signals are examined. Most of the efforts in this field are concentrated on the application of digital analyzers for pulse height analysis, pattern recognition and identification of the physical phenomena. It is demonstrated that errors in the signal processing unit can lead to dominant mistakes in the interpretation of the test results     

An engineering equation for corona devices

Engineers who either design or apply any charge-generating device are faced with characterizing the charge output of their device. This charge output per unit time is the net current output of the device. Such devices are referred to as corona-generating devices, corona chargers, or simply corona devices, and unfortunately they do not follow Ohm's Law; instead these devices display a nonlinear IV or current-voltage curve. This article deals with the development of a nonlinear IV equation that allows the characterization of the device over a large voltage range. To obtain the equation the unipolar charge injection equation is modified to account for the potential necessary to create charge injection. For a gas this potential is shown to be equal to the corona onset potential. The resulting equation is applied to some data discussed by Schaffert in his book on electrophotography and to new data from corona wires at high positive potential. Good agreement is obtained both near and away from the onset potential. The equation suggests that in the charge injection region the resistance is linearly related to the length of the injection region. The new corona data supports this hypothesis. The data also indicates the charge development region is fixed for a given geometry