Micro-structural evolution of cubic zirconia irradiated with swift heavy ions

This article deals with the study of the micro-structural properties of cubic zirconia irradiated with swift heavy ions, based on the combination of complementary analysis techniques (TEM, AFM, XRD, RBS/C). At low irradiation fluences, cross-sectional TEM observations show the creation of latent tracks in the wake of incident ions by electronic excitation processes. The melt matter flowing from ion tracks leads to the formation of large hillocks at the surface of samples revealed by AFM. At high irradiation fluences, the overlapping of tracks results in the subdivision of crystals into slightly disoriented nano-crystallites detected by XRD. RBS/C data analyzed with a Monte-Carlo simulation code confirm the occurrence of this peculiar micro-structural transformation.     

Review of 23 patients affected by the stiff man syndrome: clinical subdivision into stiff trunk (man) syndrome, stiff limb syndrome, and progressive encephalomyelitis with rigidity

OBJECTIVE: To investigate whether the stiff limb syndrome may be separated from the stiff man syndrome and progressive encephalomyelitis with rigidity on simple clinical grounds, and whether such a distinction has implications for aetiology, treatment, and prognosis. METHODS: Twenty three patients referred over a 10 year period with rigidity and spasms in association with continuous motor unit activity, but without evidence of neuromyotonia, extrapyramidal or pyramidal dysfunction or focal lesions of the spinal cord were reviewed. The patients were divided into those with an acute or subacute illness, leading to death within 1 year, and those with a chronic course. The latter were divided into those in whom rigidity and spasms dominated in the axial muscles, or in one or more distal limbs, at the time of their first assessment. RESULTS: This simple division identified three distinct groups of patients. (1) Progressive encephalomyelitis with rigidity: two patients had a rapidly progressive condition characterised by widespread rigidity which resulted in death within 6 and 16 weeks. One patient had negative anti-GAD and anti-neuronal antibodies, but had markedly abnormal CSF and widespread denervation. The principal pathological findings in this case were a subacute encephalomyelitis which primarily affected the grey matter. In the remaining patient anti-GAD antibodies were not tested, and postmortem was refused. (2) Stiff man syndrome: eight patients had rigidity and painful spasms of the lumbar paraspinal, abdominal, and occasionally proximal leg muscles associated with a lumbar hyperlordosis. There was no involvement of the upper limbs, distal lower limbs, sphincters or cranial nerves. Seven had anti-GAD antibodies and most had additional evidence of autoimmune disease. Neurophysiologically there was continuous motor unit activity with abnormal exteroceptive reflexes, but a normal interference pattern during spasms. The patients all responded to baclofen/diazepam and remained ambulant. (3) Stiff limb syndrome: thirteen patients had rigidity, painful spasm, and abnormal postures of the distal limb, ususphincter or brainstem involvement. Generalised myoclonic jerks were not a feature. Only two had truncal rigidity, and another two had anti-GAD antibodies. Most had no evidence of autoimmune disease. Neurophysiologically they had continuous motor unit activity in the affected limb, abnormal exteroceptive reflexes, and abnormally segmented EMG activity during spasms. The disease ran a protracted course, and most patients had only a partial response to baclofen or diazepam. About half became wheelchair bound. CONCLUSIONS: The stiff limb syndrome seems distinct from the stiff man syndrome or progressive encephalomyelitis with rigidity, and is an important cause of rigidity and spasm in the setting of continuous motor unit activity.     

Effect of septal and frontal ablations on species-typical behavior in the rat.

Assigned 15 male and 15 female Long-Evans rats to 3 groups: septal lesions, frontal lesions, and control. Behavioral measures were taken both pre- and postoperatively while Ss were freely interacting in a series of 5 large interconnecting chambers. Main categories of behavior observed included exploration, sleep, grooming, aggression, eating, mating, and drinking. The numerous differences found were related more often to sex and phase (pre- vs. postoperative), irrespective of lesion effects. Following behavioral observations, 2-way active-avoidance measures were obtained, and Ss with septal lesions showed the expected facilitation of avoidance behavior. The problem of comparing results derived from studies of brain damage using observational methods with those from laboratory task studies is discussed. (22 ref.) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

The lattice heat conductivity of aluminium alloys during age-hardening

This paper describes a technique for measuring the heat conductivity at quenched and annealed samples, as well as measurements at the AlMg 1-alloy. This measuring technique permits the investigation of re-arrangement processes such as the agglomeration of vacancies and point defects, which cannot be achieved using conventional techniques (measuring electric resistance).     

Use of high pressure treatment to attenuate starter bacteria for use as adjuncts for Cheddar cheese manufacture

Attenuated starter bacteria cannot produce acid during cheese manufacture, but contain enzymes that contribute to cheese ripening. The aim of this study was to investigate attenuation of starter bacteria using high pressure treatment, for use in combination with a primary starter for Cheddar cheese manufacture, and to determine the effect of such adjunct cultures on secondary proteolysis during ripening. Lactococcus lactis ssp. cremoris HP and L. lactis ssp. cremoris 303 were attenuated by pressure treatment at 200 MPa for 20 min at 20 °C. Cheddar cheese was manufactured using untreated cultures of both these starter strains, either alone or in combination with their high pressure-treated equivalents. High pressure-treated starters did not produce acid during cheese manufacture and starter counts in cheeses manufactured using high pressure-treated starter did not differ from those of the controls. Higher levels of cell lysis were apparent in cheese manufactured using high pressure-treated strains than in the controls after 26 d of ripening. Small differences were observed in the peptide profiles of cheeses, analysed by reversed-phase HPLC; cheeses manufactured using high pressure-treated starters also had slightly higher levels of amino acids than the relevant controls. Overall, addition of high pressure-treated starter bacteria as a secondary starter culture accelerated secondary proteolysis in Cheddar cheese.

Industrial relevance

Attenuated starters provide extra pool of enzymes, which can influence cheese ripening, without affecting the cheese making schedule. This paper presents an alternative method for attenuation of starter bacteria using high pressure treatment and their subsequent use to accelerate secondary proteolysis in Cheddar cheese during ripening.     

Protein,casein, and micellar salts in milk: Current content and historical perspectives

The protein and fat content of Dutch bulk milk has been monitored since the 1950s and has increased considerably, by 11 and 20%, respectively, whereas milk yield has more than doubled. The change in protein and fat content of milk is advantageous for the dairy industry, as these are the 2 most economically valuable constituents of milk. Increases in protein and fat content of milk have allowed increases in the yield of various products such as cheese and butter. However, for cheese and other applications where casein micelles play a crucial role in structure and stability, it is not only casein content, but also the properties of the casein micelles that determine processability. Of particular importance herein is the salt partition in milk, but it is unknown whether increased protein content has affected the milk salts and their distribution between casein micelles and milk serum. It was, therefore, the objective of this research to determine the salt composition and protein content for individual cow milk and bulk milk over a period of 1 yr and to compare these data to results obtained during the 1930s, 1950s, and 1960s in the last century. Calcium, magnesium, sodium, potassium, and phosphorus content were determined by inductively coupled plasma atomic emission spectrometry and inorganic phosphate, citrate, chloride, and sulfate content by anion-exchange chromatography in bulk milk and milk ultracentrifugate. In addition, ionic calcium and ionic magnesium concentration were determined by the Donnan membrane technique. We concluded that historical increase in milk yield and protein content in milk have resulted in correlated changes in casein content and the micellar salt fraction of milk. In addition, the essential nutrients, calcium, magnesium, and phosphorus in milk have increased the past 75 yr; therefore, the nutritional value of milk has improved.     

Autonomous tracking of an oceanic thermal front by a Wave Glider

Temporal variation in the structure and location of dynamic ocean features make them challenging to observe. Beyond requiring sufficient persistence and speed of the sensor platform, effective observation is augmented by autonomous feature detection coupled with adaptive localization of mapping effort. These capabilities enable observations to remain localized within and around features of interest, thereby enhancing spatial and temporal resolution in their depiction. A Wave Glider is a wave‐propelled unmanned surface vehicle with solar energy collection to support payload and a backup propeller in calm sea state. The efficiency of this platform enables persistence (months), and its propulsion system provides speed (~1 m/s). Building on these capabilities, we aim at enabling the Wave Glider to autonomously recognize and track oceanic features that have strong surface expressions, accessible to near‐surface sensors. We present a method of using a Wave Glider to autonomously track an oceanic thermal front known to have biological importance and dynamic evolution. In October 2017, this method was applied to tracking and mapping an upwelling front in Monterey Bay, CA, over 39 hr. The field result demonstrates adaptive localization of mapping based on autonomous feature detection.