A rail transportable lead–bismuth cooled reactor

A conceptual design of a small reactor cooled by lead–bismuth is developed. The main constraint on this reactor design is its transportability. The whole reactor module should be transportable on a rail cart. This imposes a volume envelope of approximately 4.5 × 4.5 × 24 m and the maximum weight of about 300 tons. Therefore, the reactor vessel is 3 m in diameter and 3.85 m tall. In order to satisfy the proliferation resistance requirements the reactor is sealed after the fuel is loaded and shall not be opened until it is shipped back after it reaches its end of lifetime after 15years. The reactor fuel is 11% and 13% enriched plutonium nitride. Reactor power is 50 MW_th which translates into 15 MW_e. Reactor pool is at nearly atmospheric pressure. Core inlet and outlet temperature are 350 and 365 °C, respectively. The reactor uses electromagnetic pumps to drive the primary coolant circulation. Secondary system consists of saturated steam cycle operating at 7 MPa and 290 °C. This reactor is well suited for secluded areas with the demand for electricity such as small islands.     

Modeling and optimization of steam dryer for removal of lead–bismuth droplets

Removal of lead–bismuth droplets from steam flow is a crucial issue in the direct contact boiling lead–bismuth cooled fast reactor. Droplets are generated due to the boiling of water directly in the reactor chimney, where steam for the turbine is generated. The droplets could severely damage the turbine and therefore a steam dryer is used for their removal. This paper presents an optimization of the main steam dryer geometrical parameters and steam inlet velocity. The Lagrangian method is used, in which first the steam flow field is developed using the CFD code FrontFlow/Red and then the particle motion is simulated. It was found that the reduction of the plate spacing can improve the steam dryer performance without a significant increase of pressure drop, the wane pitch has a value after which the steam dryer performance is not significantly improved, the number of wanes of 1.5 was selected at this point, however, a more detailed model is necessary to arrive at the final conclusion. The optimum steam inlet velocity should be found using a detailed economical assessment. Velocities between 2 and 4 m/s seem to be reasonable to achieve good removal efficiency and keep the pressure drop at reasonable values.     

Current Status of Cell-Based Therapy in Patients with Critical Limb Ischemia

(1) Background: The treatment of peripheral arterial disease (PAD) is focused on improving perfusion and oxygenation in the affected limb. Standard revascularization methods include bypass surgery, endovascular interventional procedures, or hybrid revascularization. Cell-based therapy can be an alternative strategy for patients with no-option critical limb ischemia who are not eligible for endovascular or surgical procedures. (2) Aims: The aim of this narrative review was to provide an up-to-date critical overview of the knowledge and evidence-based medicine data on the position of cell therapy in the treatment of PAD. The current evidence on the cell-based therapy is summarized and future perspectives outlined, emphasizing the potential of exosomal cell-free approaches in patients with critical limb ischemia. (3) Methods: Cochrane and PubMed databases were searched for keywords “critical limb ischemia and cell therapy”. In total, 589 papers were identified, 11 of which were reviews and 11 were meta-analyses. These were used as the primary source of information, using cross-referencing for identification of additional papers. (4) Results: Meta-analyses focusing on cell therapy in PAD treatment confirm significantly greater odds of limb salvage in the first year after the cell therapy administration. Reported odds ratio estimates of preventing amputation being mostly in the region 1.6–3, although with a prolonged observation period, it seems that the odds ratio can grow even further. The odds of wound healing were at least two times higher when compared with the standard conservative therapy. Secondary endpoints of the available meta-analyses are also included in this review. Improvement of perfusion and oxygenation parameters in the affected limb, pain regression, and claudication interval prolongation are discussed. (5) Conclusions: The available evidence-based medicine data show that this technique is safe, associated with minimum complications or adverse events, and effective.     

Immobilization of silver nanoparticles on polyethylene terephthalate

Two different procedures of grafting with silver nanoparticles (AgNP) of polyethylene terephthalate (PET), activated by plasma treatment, are studied. In the first procedure, the PET foil was grafted with biphenyl-4,4′-dithiol and subsequently with silver nanoparticles. In the second one, the PET foil was grafted with silver nanoparticles previously coated with the same dithiol. X-ray photoelectron spectroscopy and electrokinetic analysis were used for characterization of the polymer surface at different modification steps. Silver nanoparticles were characterized by ultraviolet-visible spectroscopy and by transmission electron microscopy (TEM). The first procedure was found to be more effective. It was proved that the dithiol was chemically bonded to the surface of the plasma-activated PET and that it mediates subsequent grafting of the silver nanoparticles. AgNP previously coated by dithiol bonded to the PET surface much less.     

Effect of severe plastic deformation on creep behaviour of a Ti–6Al–4V alloy

This paper examines the effect of severe plastic deformation on creep behaviour of a Ti–6Al–4V alloy. The processed material with an ultrafine-grained (UFG) structure (d ≈ 150 nm) was prepared by multiaxial forging. Uniaxial constant stress compression and constant load tensile creep tests were performed at 648–698 K and at stresses ranging between 300 and 600 MPa on the UFG processed alloy and, for comparison purposes, on its coarse-grained (CG) state. The values of the stress exponents of the minimum creep rate n and creep activation energy Q _c were determined. Creep behaviour was also investigated by nanoindentation method at room temperature under constant load. The microstructure was examined by transmission electron microscopy and scanning electron microscope equipped with an electron back scatter diffraction unit. The results of the uniaxial creep tests showed that the minimum creep rates of the UFG specimens are significantly higher in comparison with those of the CG state. However, the differences in the minimum creep rates of both states of alloy strongly decrease with increasing values of applied stress. The CG alloy exhibits better creep resistance than the UFG one over the stress range used; the minimum creep rate for the UFG alloy is about one to two orders of magnitude higher than that of the CG alloy. The indentation creep tests showed that annealing had little effect on the creep behaviour in UFG Ti alloy at room temperature.     

Atomistic simulations of dislocations and defects

This paper reviews selected recent research on the atomistic simulation of dislocation and defect properties of materials relevant to the multiscale modeling of plasticity and strength, with special emphasis on bcc metals and including work at extreme conditions. Current topics discussed include elasticity and ideal strength, dislocation structure and mobility, grain boundaries, point defects, and rapid resolidification, as well as noteworthy examples of research that directly impacts the issue of linking of length and/or time scales, as required in multiscale materials modeling. The work reviewed has been inspired by the recent international Workshop on Multiscale Modeling of Materials Strength and Failure held in October 2001 at Bodega Bay, California. This revised version was published online in June 2006 with corrections to the Cover Date.     

A Study of the Flow through Capillary Tubes Tuned for a Cooling Circuit with Saturated Fluorocarbon Refrigerants

Capillary tube expansion devices are widely used in refrigeration equipment; nevertheless, the mechanism of the flow is still not fully described and understood, so the experimental verification of most predictions is still necessary. A modified numerical model of capillary flow has been developed both for standard refrigerants and with emphasis for saturated fluorocarbon (C₂F_2n+2) refrigerants. These refrigerants have several unique properties (high dielectric performance, chemical stability, and radiation resistance). Therefore, they can be used in some special applications, where other common fluids cannot be applied. The main aim of this study was to prepare a practical capillary flow model, which would improve the procedure of predicting the behavior of capillary tubes for cooling circuits of particle detectors being built at the international CERN laboratory in Geneva. The generated numerical model was verified through available data from the literature and also via measurements performed in a real cooling circuit with pure, oil-free octafluoropropane (C₃F₈) refrigerant. Paper presented at the Seventeenth European Conference on Thermophysical Properties, September 5–8, 2005, Bratislava, Slovak Republic.     

Ionic liquids and proteases: a clean alliance for semisynthesis

Herein we present the first report on protease-catalysed ligation of cleavage-sensitive peptide and protein fragments in ionic-liquid-containing solvent systems. By applying the newly established [MMIM][Me2PO4]/buffer mixture as a reaction medium, significant advantages over purely aqueous or conventional organic solvent-containing media could be identified, including in particular the use of active wild-type proteases as biocatalysts, the suppression of any competitive proteolytic side reactions, the high turnover rates compared to classical organic solvents and the high stability of chemically labile reactants.