Sensitivity of CMOS based imagers and scaling perspectives

CMOS based imagers are beginning to compete against CCDs in many areas of the consumer market because of their system-on-a-chip capability. Sensitivity, however, is a main weakness of CMOS imagers and enhancements and deviations from standard CMOS processes are necessary to keep up sensitivity with downscaled process generations. In the introductory section several definitions for the sensitivity of image sensors are reviewed with regard to their potential to allow meaningful comparison of different detector structures. In the main section, the standard CMOS sensor architecture is compared to detector structures designed to improve the sensitivity, namely the photogate (PG), the pinned photodiode (PPD) and the thin film on ASIC (TFA) approach. The latter uses a vertical integration of the photodiode on top of the pixel transistors. A careful analysis of the relevant electrical, optical and technological parameters and many previously published experimental data for different imagers reveals that only the PPD and the TFA enhancements provide satisfactory sensitivity and withstand scaling down to 0.18 μ processes. Due to the higher fill factor and the higher quantum efficiency TFA provides significantly better values than PPD. The radiometric sensitivity of a 5 μm×5 μm TFA pixel is found to amount to 11.9 V/(μ/cm²) for a 0.25 μm process and 27.5 V/(μJ/cm²) for a 0.18 μm process     

Gold nanoparticle-based simple colorimetric and ultrasensitive dynamic light scattering assay for the selective detection of Pb(II) from paints, plastics, and water samples

Pb (II) is a common water pollutant with high toxicity. According to the CDC, about 310,000 U.S. children of ages 1-5 have high levels of lead in their blood that it is due to the exposure to lead from plastic toys and other products. As a result, the development of ultrasensitive assays for the real-time detection of Pb(II) from plastic toys and paints is very important for water controlling, clinical toxicology and industrial processes. Driven by the need to detect trace amounts of Pb(II) from water samples, we report a label-free, highly selective and ultra sensitive glutathione modified gold nanoparticle based dynamic light scattering (DLS) probe for Pb(II) recognition in 100 ppt level from aqueous solution with excellent discrimination against other heavy metals. The sensitivity of our assay to detect Pb(II) level in water is almost 2 orders of magnitude higher than the EPA standard limit. We have also demonstrated that our DLS assay is capable of measuring the amount of Pb(II) in paint, plastic toys, and water from MS river. A possible mechanism and operating principles of our DLS assay have been discussed. Ultimately, this nanotechnology driven assay could have enormous potential applications in rapid, on-site monitoring of Pb(II) from day-to-day sample.     

“Potential Health Benefits of Lunasin: A Multifaceted Soy‐Derived Bioactive Peptide”

Bioactive peptides are small protein fragments derived from enzymatic hydrolysis of food proteins, fermentation with proteolytic starter cultures, and gastrointestinal digestion. These peptides have positive impacts on a number of physiological functions in living beings. Lunasin, a soy‐derived bioactive peptide, is one of the most promising among them. Lunasin encoded within 2S albumin (GM2S‐1) gene, identified as a novel peptide extracted from soybean seed. It is composed of 43 amino acid residues with a molecular weight of 5.5 kDa. Extensive scientific studies have shown that lunasin possesses inherent antioxidative, anti‐inflammatory, anticancerous properties and could also play a vital role in regulating of cholesterol biosynthesis in the body. Its high bioavailability and heat stable nature allow its potential use as dietary supplement. The present review summarizes some of the potential health and therapeutic benefits of lunasin reported hitherto.