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41.
Howard Kenneth I.; Krause Merton S.; Vessey John T. 《Canadian Metallurgical Quarterly》1994,31(2):302
The immediate goal of any clinical trial is to determine to which of a specified set of treatments future patients are to be assigned, particularly when analyzing data from clinical trials. When the outcome distributions of Experimental (E) and Control (C) treatments overlap, differences between treatment group means are not conclusive and may not be very informative, so a display of the overlapped frequency distributions and a summary measure of the probability of a random patient in E doing better than a random patient in C are needed. When outcome distributions overlap, the question of statistical model becomes crucial even when there are very significant differences between group means and very large effect sizes. Determining what patient variables interact with treatments is the route to optimal assignment. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
42.
Bo Jiang Jeffrey L. Brown Jane Sheraton Nathalie Fortin Howard Bussey 《Yeast (Chichester, England)》1994,10(3):341-353
We have identified three yeast genes, KES1, HES1 and OSH1, whose products show homology to the human oxysterol binding protein (OSBP). Mutations in these genes resulted in pleiotropic sterol-related phenotypes. These include tryptophan-transport defects and nystatin resistance, shown by double and triple mutants. In addition, mutant combinations showed small but apparently cumulative reductions in membrane ergosterol levels. The three yeast genes are also functionally related as overexpression of HES1 or KES1 alleviated the tryptophan-transport defect in kes1Δ or osh1Δ mutants, respectively. Our study implicates this new yeast gene family in ergosterol synthesis and provides comparative evidence of a role for human OSBP in cholesterol synthesis. 相似文献
43.
Levin Harvey S.; Mendelsohn Dianne; Lilly Matthew A.; Fletcher Jack M.; Culhane Kathleen A.; Chapman Sandra B.; Harward Harriet; Kusnerik Lori; Bruce Derek; Eisenberg Howard M. 《Canadian Metallurgical Quarterly》1994,8(2):171
To investigate the relationship of severity of pediatric closed head injury (CHI), the contribution of frontal lobe lesions, and age at testing (6–10 yr olds vs 11–15 yr olds) to cognitive deficit, 134 head-injured patients were given the Tower of London (TOL) task and underwent magnetic resonance imaging. 89 normal controls were given the TOL for comparison. Severity of CHI and age at testing were strongly related to cognitive performance on the TOL, including the frequency of breaking the rules. Volume of frontal lobe lesion (but not extrafrontal lesion) contributed to the prediction of perfomance on the TOL even after severity of injury was taken into account. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
44.
Howard R. Moskowitz Michele Reisner Barbara Itty Rachel Katz Bert Krieger 《Food quality and preference》2006,17(7-8):536-551
Innovation is often left to insight and serendipity. A lot of what researchers call innovation is actually a process by which one can make the individual consumer or practitioner more ‘creative’. Although it is important to work with the creative individual in hopes of coming up with the better ‘idea’ and new product/service opportunity, an equally valid albeit novel and counterintuitive approach systematizes creativity in a ‘research-driven machine’. This paper presents an approach to the systematization, based upon the point of view that creativity and innovation comprise the recombination of components into new blends. Given this point of view, to then spur innovation requires a systematic database that the user can access, with tools to help manipulate that database. The paper shows how such a database can be constructed and then used to create a novel product. The approach provides a general framework for the sensory professional to become more involved in the early stages of product development, where the focus is on the conceptual aspects of food features rather than on their physical manifestations in actual products. 相似文献
45.
J. C. Viala P. Fortier G. Claveyrolas H. Vincent J. Bouix 《Journal of Materials Science》1991,26(18):4977-4984
This work was undertaken in order to provide more detailed information on the chemical and mechanical behaviour of carbon fibres during the elaboration of graphite-magnesium composite materials. For this purpose, PAN-based T300, pitch-based P55 and P100 carbon fibres were isothermally heat treated, at temperatures ranging from 450 to 700 °C, under a saturated vapour pressure of magnesium. The composition, microstructure and tensile strength of the resulting samples were characterized by chemical and electron probe microanalysis, Raman spectrometry, X-ray diffraction and mechanical test of single filaments. From the results obtained, it has been concluded that highly graphitized fibres such as pitch-based P55 or P100 are not affected by long-time annealing in the presence of magnesium vapour, whereas impure and disorded fibres such as PAN-based T300 undergo some chemical and microstructural modifications decreasing their mechanical properties. 相似文献
46.
Signal classification through multifractal analysis and complex domain neural networks 总被引:1,自引:0,他引:1
W. Kinsner Vincent Cheung K. Cannons J. Pear T. Martin 《IEEE transactions on systems, man and cybernetics. Part C, Applications and reviews》2006,36(2):196-203
This paper describes a system capable of classifying stochastic self-affine nonstationary signals produced by nonlinear systems. The classification and the analysis of these signals are important because these are generated by many real-world processes. The first stage of the signal classification process entails the transformation of the signal into the multifractal dimension domain, through the computation of the variance fractal dimension trajectory (VFDT). Features can then be extracted from the VFDT using a Kohonen self-organizing feature map. The second stage involves the use of a complex domain neural network and a probabilistic neural network to determine the class of a signal based on these extracted features. The results of this paper show that these techniques can be successful in creating a classification system which can obtain correct classification rates of about 87% when performing classification of such signals without knowing the number of classes. 相似文献
47.
48.
This paper analyses inter-organizational networks that link together firms operating in the food processing and distribution industry in the UK. In doing so, the paper draws on insights recently developed by Mark Casson that treat inter-firm networks as an institutional response to the changing costs and opportunities of information management. Detailed analysis of product innovation and supply-chain management issues within the industry, exemplified by the growth of chilled ready-meals, leads to the identification of two distinct but complementary inter-firm networks: a network of control and a network of innovation. In each case, the study finds that the critical information is derived from the retailers' interface with consumers and thus that these information-based networks are effectively controlled by the leading supermarket chains. The study's conclusions are considered in relation to the recent findings of the UK Competition Commission following its investigation into grocery retailing in Britain. 相似文献
49.
Tresadern P.A. Thies S.B. Kenney L.P.J. Howard D. Goulermas J.Y. 《Pervasive Computing, IEEE》2008,7(2):62-69
The clinical set-up tool integrates fast parameter selection and a user-friendly interface to help electrical muscle stimulators more efficiently treat patients with neurological injuries. A key challenge in increasing functional electrical stimulation systems' clinical acceptance is facilitating or automating parameter selection, optimization, and programming to make the underlying engineering transparent to the user. To this end, we present the clinical set-up tool (CST), a finite-state-machine-based controller that integrates accurate, automatic parameter optimization in an intuitive user interface. Unlike other approaches, we employ a numerical algorithm that uses real-life data and well-defined criteria to rapidly optimize parameter values. 相似文献
50.