On the Easy Use of Scientific Computing Services for Large Scale Linear Algebra and Parallel Decision Making with the P-Grade Portal

Scientific research is becoming increasingly dependent on the large-scale analysis of data using distributed computing infrastructures (Grid, cloud, GPU, etc.). Scientific computing (Petitet et al. 1999) aims at constructing mathematical models and numerical solution techniques for solving problems arising in science and engineering. In this paper, we describe the services of an integrated portal based on the P-Grade (Parallel Grid Run-time and Application Development Environment) portal (http://www.p-grade.hu) that enables the solution of large-scale linear systems of equations using direct solvers, makes easier the use of parallel block iterative algorithm and provides an interface for parallel decision making algorithms. The ultimate goal is to develop a single sign on integrated multi-service environment providing an easy access to different kind of mathematical calculations and algorithms to be performed on hybrid distributed computing infrastructures combining the benefits of large clusters, Grid or cloud, when needed.     

Approximation algorithm for coloring of dotted interval graphs

Dotted interval graphs were introduced by Aumann et al. [Y. Aumann, M. Lewenstein, O. Melamud, R. Pinter, Z. Yakhini, Dotted interval graphs and high throughput genotyping, in: ACM-SIAM Symposium on Discrete Algorithms, SODA 2005, pp. 339-348] as a generalization of interval graphs. The problem of coloring these graphs found application in high-throughput genotyping. Jiang [M. Jiang, Approximating minimum coloring and maximum independent set in dotted interval graphs, Information Processing Letters 98 (2006) 29-33] improves the approximation ratio of Aumann et al. [Y. Aumann, M. Lewenstein, O. Melamud, R. Pinter, Z. Yakhini, Dotted interval graphs and high throughput genotyping, in: ACM-SIAM Symposium on Discrete Algorithms, SODA 2005, pp. 339-348]. In this work we improve the approximation ratio of Jiang [M. Jiang, Approximating minimum coloring and maximum independent set in dotted interval graphs, Information Processing Letters 98 (2006) 29-33] and Aumann et al. [Y. Aumann, M. Lewenstein, O. Melamud, R. Pinter, Z. Yakhini, Dotted interval graphs and high throughput genotyping, in: ACM-SIAM Symposium on Discrete Algorithms, SODA 2005, pp. 339-348]. In the exposition we develop a generalization of the problem of finding the maximum number of non-attacking queens on a triangle.     

Boosted Bayesian network classifiers

The use of Bayesian networks for classification problems has received a significant amount of recent attention. Although computationally efficient, the standard maximum likelihood learning method tends to be suboptimal due to the mismatch between its optimization criteria (data likelihood) and the actual goal of classification (label prediction accuracy). Recent approaches to optimizing classification performance during parameter or structure learning show promise, but lack the favorable computational properties of maximum likelihood learning. In this paper we present boosted Bayesian network classifiers, a framework to combine discriminative data-weighting with generative training of intermediate models. We show that boosted Bayesian network classifiers encompass the basic generative models in isolation, but improve their classification performance when the model structure is suboptimal. We also demonstrate that structure learning is beneficial in the construction of boosted Bayesian network classifiers. On a large suite of benchmark data-sets, this approach outperforms generative graphical models such as naive Bayes and TAN in classification accuracy. Boosted Bayesian network classifiers have comparable or better performance in comparison to other discriminatively trained graphical models including ELR and BNC. Furthermore, boosted Bayesian networks require significantly less training time than the ELR and BNC algorithms.     

Multistable electro‐optical modes in ferroelectric liquid crystals

Abstract— Multistable electro‐optical modes exist under certain conditions in ferroelectric liquid‐crystal (FLC) cells, which means that any light‐transmission level can be memorized after the driving voltage is switched off. The multistability is responsible for three new electro‐optical modes with different shapes of the gray‐scale curve that can be either S‐shaped (double or single dependent upon the applied‐voltage pulse sequence and boundary conditions) or V‐shaped dependent upon boundary conditions and FLC cell parameters. The origin of these modes will be described.     

The differences in underground mines dewatering with the application of caving or backfilling mining methods

Zambia Consolidated Copper Mines Ltd. (ZCCM) is planning a substantial increase in ore production in several of their underground mines on the Zambian Copperbelt over the next 10 years. The future production strategy is based on development of productive and economic mining methods through the application of mechanization and backfilling. Mechanization is designed to provide the production capability and the backfilling is designed to reduce water inflow into the mines. A similar trend can be seen in world-wide changes in mining methods from open stoping and sub-level caving to cut-and-fill stoping. Backfill is being employed worldwide, including in Australia, Canada, Sweden, Latin America, Zambia, and the U.S.A. Plans for backfill mining methods are underway for future operations in Chile, Canada, Zambia, and Mexico. The principal reasons for these changes in mining methods are twofold:

? Increased ore recovery, and

? Decreased environmental impact.

The main difference in the environmental impacts between mining with sub-level caving or open stoping and mining with backfilling methods is the reduction in subsidence or the potential for subsidence. Backfilling reduces ground movements in the rock overlying and adjacent to mine openings as well as subsidence at the surface. Reduced ground movement decreases the number and size of fracture-controlled hydraulic flow paths into a mine and, thereby, the impact of mining on surface and ground water resources. This paper deals with: 1) The impacts caused by open stoping and sub-level caving in comparison to backfilling methods; 2) The approximate impact of backfill on dewatering strategies, and; 3) The environmental benefits of backfill mining. The differences in mine drainage strategies are supported by case histories from various mines.     

Redox and pH Dual Responsive Polymer Based Nanoparticles for In Vivo Drug Delivery

Responsive nanomaterials have emerged as promising candidates as drug delivery vehicles in order to address biomedical diseases such as cancer. In this work, polymer‐based responsive nanoparticles prepared by a supramolecular approach are loaded with doxorubicin (DOX) for the cancer therapy. The nanoparticles contain disulfide bonds within the polymer network, allowing the release of the DOX payload in a reducing environment within the endoplasm of cancer cells. In addition, the loaded drug can also be released under acidic environment. In vitro anticancer studies using redox and pH dual responsive nanoparticles show excellent performance in inducing cell death and apoptosis. Zebrafish larvae treated with DOX‐loaded nanoparticles exhibit an improved viability as compared with the cases treated with free DOX by the end of a 3 d treatment. Confocal imaging is utilized to provide the daily assessment of tumor size on zebrafish larva models treated with DOX‐loaded nanoparticles, presenting sustainable reduction of tumor. This work demonstrates the development of functional nanoparticles with dual responsive properties for both in vitro and in vivo drug delivery in the cancer therapy.