Iron catalyzes both decomposition and synthesis of S-nitrosothiols: optical and electron paramagnetic resonance studies

This paper discusses the issues of providing an empirically validated, manual-based-treatment when viewed from the perspective of a practicing clinical psychologist. The trend for empirically proven treatment is reviewed briefly, and initial data are provided illustrating a manual-based-treatment for post-traumatic stress disorder (PTSD) following a motor vehicle accident. The relatively brief (9-12 session) psychological treatment was effective in reducing PTSD symptoms as measured on the Clinician Administered PTSD Scale, for all 10 subjects. The results are discussed form the practicing clinician's perspective: generalization to a clinical population, ethical concerns of limited treatment goals, individually tailored vs standardized treatments in clinical practice, concerns for co-morbid conditions, and how this type of study might impact on practice in an era of managed health care. Issues of incorporating manual based treatments into clinical practice are discussed, with consideration of gains, the limits and the constraints this would bring to the practice of psychology.     

Low-flow membrane oxygenation of blood in patients with diffuse purulent peritonitis

Small-flow membranous oxygenation of the blood was used in 45 patients with peritonitis in the multiple organ failure phase. In ten cases blood oxygenation was combined with hemofiltration. MOCT 19-03 (Kvant Research and Production Unit) and Gambro FH hemofilters (Sweden) were employed. Combination of small-flow membranous oxygenation of the blood combined with hemofiltration appreciably improved the oxygen-transporting function of the blood in adult patients with the respiratory distress syndrome, which was due to mutual potentiation of the two methods' effects. Small-flow membraneous oxygenation alone improved cellular immunity and decreased the laboratory manifestations of endogenous intoxication due to biotransformation of toxic products.     

The possibility of preserving the causative agent of plague in soil in resting (nonculturable) form

The purpose of this study was to find criteria characteristic for patients in need of care and social services. The criteria should serve as a guideline for patients and staff to facilitate care planning before discharge. The sample consisted of 49 patients, born before 1925, in need of emergency inpatient treatment, admitted to medical- or orthopaedic wards. Data of the patient's self care needs were collected by interviews, assessment of self care status and need of treatment. The patients could be divided into three groups depending on type of discharge. Group A (n = 27) discharged home, group B (n = 7) discharged to geriatric clinic and group C (n = 15) discharged and in need of further care and social services. Criteria indicating the patients further assistance from the community were in group C (medical- and orthopaedic wards) deficit in daily living activities and locomotion. Group B had an increased need of support from the physiotherapist and the occupational therapist, in locomotion as well as daily living activities The physician's assessment showed that the criteria behind the decision "no further medical treatment appropriate" and "ready for discharge" were not related to medical impairment but to lack of self care, need of care, rehabilitation and social services.     

A clinico-laboratory validation of the combined therapy of lichen ruber planus of the oral mucosa

Fifty-two patients with lichen planus were examined over the course of disease using clinical, microbiological, and histological methods. Treatment protocols aimed at normalization of microbiocenosis have been developed, based on the detected microbiological and histological changes.     

Comparison of Operant Escape and Innate Reflex Responses to Nociceptive Skin Temperatures Produced by Heat and Cold Stimulation of Rats.

In behavioral tests, rats performed learned escape responses to thermal stimulation of the paws by 44.0. 47.0. or 0.3 degrees C. Licking, guarding, and jumping reflexes were evaluated at these temperatures. The frequency, latency, and duration of escape and reflex responses were compared and were related to hind-paw skin temperatures measured during stimulation of awake and anesthetized rats. The duration and latency of escape from heat were appropriately related to stimulus intensity. Escape occurred reliably for each intensity. Reflexes occurred unreliably and at long latency to 44.0 or 0.3 degrees C and were not appropriately related to heat intensity. The reflexes were relatively insensitive to thermal nociceptive stimulation other than heating of the skin at a high rate. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Chromosome variation and anomalous karyotypes in the red-backed mouse Clethrionomys rufocanus (Rodentia, Microtinae)

G-banding and C-banding of chromosomes were studied in populations of the red-backed mouse Clethrionomys rufocanus from 11 localities of eastern Russia. Intrapopulation polymorphism of autosome 3 caused by the deletion-duplication of the short-arm heterochromatin (2n = 56; NFa = 56-58) was demonstrated. The karyotype of Cl. rufocanus from continental populations and Sakhalin Island was shown to have a large subtelocentric chromosome of pair 3 (NFa = 58), whereas in the population from Kunashir Island, chromosomes of this pair were acrocentric (NFa = 56). One animal from the population of the Kedrovaya Pad' Reserve (Primorsk krai) had a pericentric inversion (acrocentric morphology) of the Y chromosome. In two animals, a female from the Ussuriiskii Reserve (Primorsk krai) and a male captured near the Tomari Settlement (Sakhalin Island), a pericentric inversion of one chromosome of pair 6 was found (NFa = 59). The inversion detected in the animal from the Sakhalin population was accompanied by the loss of the centromeric heterochromatin. In contrast, the inversion of the chromosome pair 6, which was found in the mouse from the Primorsk krai population, did not involve the loss of centromeric heterochromatin. Analysis of our results and data from the literature showed that the karyotype of Cl. rufocanus is not constant, as was thought earlier. The percentage of animals with abnormal karyotype (1.6%) was higher than in other groups of red-backed mice studied (0.12-0.7%).     

Spontaneous regression of familial glioma of the optic nerve in a boy with suspected neurofibromatosis 1 (Recklinghausen''s disease)

A boy with a large intracranial glioma of the optic tract and probable neurofibromatosis of the first type was observed for 8 years since the age of 7 years. A series of MR scans was made over this period. A notable decrease of the tumor size was seen on its signals on the MR scans. This was paralleled by an improvement of the vision acuity, color field, and visual field on the involved eye. Patient's grandmother had an intracranial glioma of the optic nerve with a slight but stable decrease of the visual functions. The tumor shape in the grandmother and grandchild is remarkably similar. This finding in the grandmother and stability of her vision decreased from childhood permit us to propose that the tumor did not develop and even regressed with time.     

Effect of pH on tobacco anionic peroxidase stability and its interaction with hydrogen peroxide

The dendritic localization of mRNAs has been proposed to underlie the structural and functional polarity of neurons, as well as certain aspects of synaptic plasticity. Even though there is no conclusive evidence that such a localization is a physiological requirement, studies of mRNA localization in relation to function in other cell types and recent experiments on synaptic plasticity suggest that this proposal may be correct.     

New methods of rectum and colon x-ray study in patients with constipation

In the 14, 3 and 90 day-experiments with tail-suspended rats, histochemical determination of myosin ATP-ase activity in m. soleus and m. gastrocnemius preincubated in acid and neutral media was followed by measurement of the cross-sectional areas (CSAs) of muscular fibers (MF) and calculation of the percentage of various types of MF. By day 30 of testing atrophy in m. soleus reached maximum and stabilized. By that time, MF CSAs were less than in the control by 69, 62, and 68% in MF-I, -IIA and -IIC, respectively. Slow MF underwent the transformation into fast and intermediate. In slow MF this process peaked by day 3 when the number of these fibers decreased by 28% as compared to the control, and stabilized. The transformation of intermediate fibers into the fast ones was progressing simultaneously. This process was not finished by day 90. Atrophy of m. gastrocnemius was less pronounced than in m. soleus. On day 14 of experiment, MF CSAs, except for IIB, were by 30% smaller than in the control. Type IIB MF were less affected as their CSAs decreased by only 17% as compared with the control. On day 90, CSAs in both slow and IIC-type fast MFs remained approximately same as in the rats investigated on day 14. Fast MF CSAs either tended to (IIA) or regained (IIB) the norm. Hence, atrophy in m. gastrocnemius stabilized earlier than in m. soleus. Besides, longer suspension led to a partial or complete reconstruction of two out of three types of fast fibers. The percent ratio of MFs was unchanged; however, during the ATP-ase determination slow IB-type MFs assumed th color typical of fast MFs.