Coherence-Based 3-D and Spectral Imaging and Laser-Scanning Microscopy

The basics of three-dimensional (3-D) and spectral imaging techniques that are based on the detection of coherence functions and other related techniques are reviewed. The principle of the 3-D source retrieval is based on understanding the propagation law of optical random field through the free space. The 3-D and spectral information are retrieved from the cross-spectral density function of optical random field or numerical calculation of the inverse propagation of the cross-spectral density. We will first introduce the coherence-based spectral tomography techniques with low-coherence light sources. These techniques limit their scheme of coherence detection only along the optical axis and some of them achieve simultaneously the high resolution and high speed of detection taking advantage of an imaging lens. We then provided explanations of the principle of 3-D source retrieval that is based on the propagation law of optical random field through the free space along with the introduction of the numerical holography and computed tomography techniques. We will lastly show 3-D spectral imaging schemes with the concurrent laser-scanning cross-sectioning techniques: one is the confocal laser scanning microscopy and the other is the two-photon laser-scanning fluorescence microscopy.     

Kinetics of AuSn4 migration in lead-free solders

The relatively fast diffusion of Au atoms in eutectic PbSn matrix is considered one of the contributing factors to the Au embrittlement problem. In this study, we further investigated the Au embrittlement problem in high-Sn solders. Experimentally, Sn3.5Ag (wt.%) spheres with 500-μm diameter were soldered over the Au/Ni soldering pads. It was found that some of the AuSn₄ needles that formed after reflow inside the solder migrated back to the solder/pad interface during thermal aging. However, the migration kinetics in high-Sn solders was slower compared to that in eutectic PbSn. The difference in migration kinetics of AuSn₄ in eutectic PbSn and SnAg was ascribed to the difference in the magnitudes of the Au flux and the Ni flux. In eutectic PbSn, the Au flux was much greater than that of the Ni flux, and the Au and Ni flux were in the same order of magnitude in eutectic SnAg. The relative magnitude of the Au and Ni flux changed in eutectic PbSn and SnAg because the homologous temperatures of PbSn and SnAg were different.     

Yielding- and fracture behaviour of ferritic steels in the transition region of quasistatic to dynamic loading

This paper presents results of investigations on the influence of loading rate on yielding and fracture behaviour of ferritic steels. The range of loading rates was below a certain level at which a special stress wave analysis is required. Concerning the yielding behaviour it was found, that the yield strength can be predicted by the model of thermally activated flow. The strain hardening dσ/dε appeared to be independent of strain rate, if adiabetic heating can be neglected. Concerning the fracture behaviour it is demonstrated that the K_lc-T-curves are shifted to higher temperatures with increasing loading rate. The temperature shift could be correlated with the strain rate sensitivity m = d lnσ/d lnε. The ductile/brittle transition temperature increases with incrasing loading rate. For the upper shelf region crack resistance curves as a function of loading rate are presented. It is shown that the crack length can be determined using the key-curve-method. A slightly increasing tendency of the evaluated J_R-curves was found.     

2.5-dimensional VLSI system integration

The excessive interconnection delay and fast increasing development cost, as well as complexity of the single-chip integration of different technologies, are likely to become the major stumbling blocks for the success of monolithic system-on-chips. To address the above problems, this paper investigates a new VLSI integration paradigm, the so-called 2.5-dimensional (2.5-D) integration scheme. Using this scheme, a VLSI system is implemented as a three-dimensional stacking of monolithic chips. A cost analysis framework was developed to justify the 2.5-D integration scheme from an economic point of view. Enabling technologies for the new integration scheme are also reviewed.     

Clinical trial of a new lightwand device (Trachlight) to intubate the trachea

BACKGROUND: Transillumination of the soft tissue of the neck using a lighted stylet (lightwand) is an effective and safe intubating technique. A newly designed lightwand (Trachlight) incorporates modifications to improve the brightness of the light source as well as flexibility. The goal of this study was to determine the effectiveness and safety of this device in intubating the trachea of elective surgical patients. METHODS: Healthy surgical patients were studied. Patients with known or potential problems with intubation were excluded. During general anesthesia, the tracheas were intubated randomly using either the Trachlight or the laryngoscope. Failure to intubate was defined as lack of successful intubation after three attempts. The duration of each attempt was recorded as the time from insertion of the device into the oropharynx to the time of its removal. The total time to intubation (TTI), an overall measure of the ease of intubation, was defined as the sum of the durations of all (as many as three) intubation attempts. Complications, such as mucosal bleeding, lacerations, dental injury, and sore throat, were recorded. RESULTS: Nine hundred fifty patients (479 in the Trachlight group and 471 in the laryngoscope group) were studied. There was a 1% failure rate with the Trachlight, and 92% of intubations were successful on the first attempt, compared with a 3% failure rate and an 89% success rate on the first attempt with the laryngoscope (P not significant). All failures were followed by successful intubation using the alternate device. The TTI was significantly less with the Trachlight compared with the laryngoscope (15.7 +/- 10.8 vs. 19.6 +/- 23.7 s). For laryngoscopic intubation, the TTI was longer for patients with limited mandibular protrusion and mentohyoid distance, with a larger circumference of the neck, and with a high classification according to Mallampatti et al. However, there was no relation between the TTI and any of the airway parameters for Trachlight. There were significantly fewer traumatic events in the Trachlight group than in the laryngoscope group (10 vs. 37). More patients complained of sore throat in the laryngoscope group than in the Trachlight group (25.3% vs. 17.1%). CONCLUSIONS: In contrast to laryngoscopy, the ease of intubation using the Trachlight does not appear to be influenced by anatomic variations of the upper airway. Intubation occasionally failed with the Trachlight but in all cases was resolved with direct laryngoscopy. The failures of direct laryngoscopy were resolved with Trachlight. Thus the combined technique was 100% successful in intubating the tracheas of all patients.     

Flaw density examinations of a clad boiling water reactor pressure vessel segment

As part of the Oak Ridge National Laboratory's Heavy-Section Steel Technology Program, studies have been conducted to determine flaw density in a section of reactor pressure vessel cut from the Hope Creek Unit 2 vessel. This boiling water reactor vessel was never in service. One objective was to evaluate the approximate 0.7- by 3-m (2- by 10-ft) segment of the vessel provided using ultrasonic flaw detection methods performed with both ASME Code techniques and supplemental ultrasonic methods. A second objective was to evaluate the inner surface stainless steel cladding for cracks with a high sensitivity penetrant examination. Both objectives were successfully completed. Five Code-recordable indications were detected ultrasonically; however, all were found to be anomalies associated with the cladding. One flaw was detected by the supplemental ultrasonic tests, and it was analyzed destructively. This flaw was pipelike indication, about 20 mm (0.8 in.) long extending along the length of the longitudinal weld in which it was located and was about 20 mm below the cladding surface. The flaw had a through-wall dimension (or length) of about 6 mm (0.24 in.) for an approximate 3-mm (0.1-in.) distance along the 20-mm major length. No flaws were detected by the penetrant examination of the cladding surface.     

Structure of metal site in Cd-substituted His117Gly mutant of azurin with and without addition of imidazole derivatives

The present work uses 111mCd-perturbed angular correlations of gamma-rays (PAC) to investigate the structure of the metal site of the His117Gly mutant of Pseudomonas aeruginosa azurin in aqueous solution and the effect on the structure upon addition of the following exogenous ligands: imidazole, 4-methyl imidazole, 1-methyl imidazole, 2-methyl imidazole and histidine. The nuclear quadrupole interaction of cadmium bound to the mutant without addition of exogenous ligands shows a strong pH dependence with three different nuclear quadrupole interactions consistent with two pKa values at about 7.2 and 8.6 at 2 degrees C. Addition of the imidazole derivatives resulted in a significant change in the PAC spectrum showing that they coordinate. This is in accordance with observations by EPR for the same mutant with copper at the metal site [den Blaauwen, T. & Canters, G. W. (1993) J. Am. Chem. Soc. 115, 1121-1129]. However, whereas EPR and ultraviolet/visual absorption show that the characteristics of the wild-type copper protein are regained by addition of the imidazole derivatives with the exception of the possible bidentates (histidine and histamine), the comparison of the PAC results to model calculations shows that the cadmium ion must be fourfold coordinated in most cases, probably binding an additional water or hydroxide ligand. A fourfold coordination is in contrast to cadmium-substituted wild-type azurin where PAC data inferred a threefold coordination by a Cys and two His residues [Danielsen, E. Bauer, R., Hemmingsen, L., Andersen. M., Bjerrum, M. J., Butz, T., Tr?ger, W., Canters, G. W., Hoitink, C. W. G., Karlsson, G., Hansson, O. & Messerschmidt, A. (1995) J. Biol. Chem. 270, 573-580]