Fanconi anemia complementation group E: clinical and cytogenetic data of the first patient

The clinical and cytogenetic data of the first patient proven to belong to the fifth Fanconi anemia complementation group are described. The Turkish boy presented with psychomotoric retardation, growth retardation, retarded bone age, brachycephaly, hypotelorism, epicanthus, syndactyly, brachydactyly, renal dystopia, and cryptorchism. In addition, an asymmetrical skeletal anomaly was seen with a double distal phalanx of the left thumb and hypoplasia of the right thumb. Typical hematological features of the disorder developed, at the age of 2.5 years, about 1 year after diagnosis. Cytogenetic studies confirmed the clinical diagnosis and revealed a spontaneous chromosomal instability and hypersensitivity to the cross-linking agents diepoxybutane and Trenimon. The findings in the patient, who is considered to be the standard for the fifth Fanconi anemia complementation group, are compared with data reported for other patients affected with Fanconi anemia.     

Highly efficient ceramic catalytic blocks with a honeycomb structure

Compositions and technologies are suggested for preparing highly efficient catalyst blocks with a honeycomb structure to be used for reducing nitrogen oxides with ammonia in flue gases from thermal power plants. The blocks have high structural strength and catalytic activity.     

Numerical investigation of the convection of heat-emitting liquid reactor materials taking stratification into account

Conclusions The calculations for the different levels of volume heat release showed that the integral heat fluxes at the lateral and top surfaces are virtually independent of the scenario of convective flow. However, the maximum of the heat flux on the lateral surface in the homogeneous case is 1.5–1.6 times higher than the maximum heat flux in the stratified case. This could result in larger mechanical loads on the reactor vessel and therefore more stringent requirements on the cooling of the outer surface of the reactor vessel. Institute of Fast Reactors, Russian Academy of Sciences. Translated from Atomnaya énergiya, Vol. 76, No. 5, pp. 406–411, May, 1994.     

Determination of the intensity of emission of a radioactive contaminant from the ventilation pipes of a nuclear power plant

All-Union Scientific-Research Institute of Nuclear Power Plants NIIP. Translated from Atomnaya énergiya, Vol. 77, No. 5, pp. 392–402, November, 1994.     

Clonal analysis of peripheral blood lymphocytes from three patients with advanced neuroblastoma receiving recombinant interleukin-2 and interferon alpha

Cultures of both isolated and conjugated explants from early gastrulae of Bufo arenarum were prepared for a study of the development of ventral mesoderm. Only combinations including components of the deep ventral marginal zone and the animal pole successfully differentiated into blood cells (erythrocytes). Histological studies indicated that, while prospective mesodermal cells constituted the only source of such cells, prospective ectodermal cells provided the necessary stimulus for this kind of differentiation. Differentiated cultures, in which the tracer of cell-lineage fluorescein dextran amine was used to label these components, confirmed the above conclusions. These findings are discussed in the context of current concepts about the formation of mesoderm.     

Topical use of aprotinin in open heart operations

Among various pharmacological agents used to reduce bleeding after open-heart operations, high-dose aprotinin therapy seems most promising. However, its long-term effects are still obscure; there is almost always possibility of bypass graft occlusions produced by the hypercoagulable state induced by aprotinin in coronary bypass operations. Topical application of aprotinin into the pericardial cavity could prevent the adverse effects. Fifty patients were prospectively studied to evaluate the effects of topical aprotinin. One million KIU of aprotinin was poured into the pericardial cavity before closure of the sternotomy in group 1 (n = 25). Patients in group 2 (n = 25) served as controls. Total postoperative bleeding was significantly reduced in group 1 when compared with that of group 2 (722.7 +/- 230.8 versus 1,282.6 +/- 225.7 mL; p < 0.01). The use of banked donor blood products was significantly less in group 1 than in group 2 (0.33 +/- 0.67 versus 1.36 +/- 0.86 units; p < 0.01). These results show that topical use of aprotinin reduces post-operative blood loss and need for transfusion. It seems promising and warrants further studies to be done.     

Improving the emf and dc voltage measuring system (discussion paper)

The concept of a new system of emf and dc voltage measurements is and methods of its implementation capable to satisfy the predicted demands of the Russian economy for 2003–2010 are proposed as a matter of discussion. Translated from Izmeritel'naya Tekhnika, No. 10, pp. 34–37, October, 1998.     

Calculi with the greatest number

Translated from Kibernetika i Sistemnyi Analiz, No. 3, pp. 71–86, May–June, 1995.     

Changes in activity of alpha amylase and its salivary isoenzyme in serum and urine after surgical treatment of ovarian neoplasms

Serum and urinary activity of alpha-amylase and isoamylase salivary was assessed in 40 patients with different types of ovarian cancer. The measurements were performed before surgical procedure and the 7th day after surgical removal of the tumor. Significant increases activity was found in patients with serosal ovarian cancer p < 0.001. On the 7th day after operation the activity of alpha-amylase and her of isoenzyme salivary reached control values.