On the feasibility of introducing auxetic behavior into thin-walled structures

Classical elasticity theory indicates that the existence of negative Poisson’s ratios (NPRs), i.e. auxetic behavior in materials, will result in an increase in shear stiffness. Motivated by the assumption of gaining potential structural benefits, this study undertook to examine two main issues: (i) the feasibility of inducing auxetic behavior into thin-walled structures; and (ii) in cases where it is possible, whether it leads to shear stiffness enhancement. In the present study, the geometry of a membrane was chosen as a geometric model to address these issues. The results obtained in this study reveal that on the one hand the model effective elastic properties, E¹ and G¹, are lower than those of the material the surface is fabricated from, E¹ ～ 1% of the material elastic modulus and G¹ ～ 80% of its shear modulus. On the other hand, the obtained properties are much higher than those observed for other available auxetics like honeycombs, foams and polymers.     

Effects of persistency and production on the genetic parameters of milk and fat yield in Israeli-Holsteins

Herd-years of Israeli-Holsteins were stratified into three groups by two criteria: mean annualized milk yield [365 (total lactations yield/calving interval)] and mean persistency, estimated as the ratio of daily milk production at the 5th mo postpartum to daily production during the postpartum peak period. The latter was taken as an indication of the relative environmental stress on the cow. Primi- and multiparous cows were analyzed separately. Genetic parameters were estimated for annualized milk and fat production at each production and persistency group. Heritabilities increased with a rise in production for both primiparous and multiparous cows, but the effect was greater for multiparous cows. Even though persistency and production were correlated, no clear trends were evident for stratification by persistency; thus, a relationship between stress and heritability was not established. Genetic correlations among stratification groups were between .7 and .9 for persistency and between .6 and .86 for production; thus, sire x environmental interaction was greater for production than for persistency stratification. Production in a given year can be used as a criterion for selecting herds to test progeny of young sires in the following year.     

Internal friction of the glassy tektites

Tektites are naturally occurring glasses, perhaps of meteoritic origin. They occur all over the world. They range in size from μm to decimeter. They are based on the compounds silica and alumina, with smaller concentrations of alkali metal and transition metal oxides. Their origin is in vigorous dispute; some scientists think they are of terrestrial earth origin, others believe they come from interplanetary space, as is true of meteorites. We have secured seven specimens from various regions of the earth and have measured the internal friction spectrum of several in the kilocycle frequency range above room temperature, where internal friction peaks of synthetic glasses have been observed. A well defined loss peak is observed around 500 K in a number of specimens. We have also measured the loss spectrum of obsidian and of blast furnace slag. From comparison of these measurements, we conclude that tektites are probably of volcanic origin, the loss peaks being associated with the reorientation of Fe–oxygen complexes.     

Adenovirus-mediated gene transfer of inhibitors of apoptosis protein delays apoptosis in cerebellar granule neurons

The inhibitor of apoptosis (IAP) family of antiapoptotic genes, originally discovered in baculovirus, exists in animals ranging from insects to humans. Here, we investigated the ability of IAPs to suppress cell death in both a neuronal model of apoptosis and excitotoxicity. Cerebellar granule neurons undergo apoptosis when switched from 25 to 5 mM potassium, and excitotoxic cell death in response to glutamate. We examined the endogenous expression of four members of the IAP family, X chromosome-linked IAP (XIAP), rat IAP1 (RIAP1), RIAP2, and neuronal apoptosis inhibitory protein (NAIP), by semiquantitative reverse PCR and immunoblot analysis in cultured cerebellar granule neurons. Cerebellar granule neurons express significant levels of RIAP2 mRNA and protein, but expression of RIAP1, NAIP, and XIAP was not detected. RIAP2 mRNA content and protein levels did not change when cells were switched from 25 to 5 mM potassium. To determine whether ectopic expression of IAP influenced neuronal survival after potassium withdrawal or glutamate exposure, we used recombinant adenoviral vectors to target XIAP, human IAP1 (HIAP1), HIAP2, and NAIP into cerebellar granule neurons. We demonstrate that forced expression of IAPs efficiently blocked potassium withdrawal-induced N-acetyl-Asp-Glu-Val-Asp-specific caspase activity and reduced DNA fragmentation. However, neurons were only protected from apoptosis up to 24 h after potassium withdrawal, but not at later time points, suggesting that IAPs delay but do not block apoptosis in cerebellar granule neurons. In contrast, treatment with 100 microM or 1 mM glutamate did not induce caspase activity and adenoviral-mediated expression of IAPs had no influence on subsequent excitotoxic cell death.     

Zur Bestimmung der St?rke in Wurstwaaren

Ohne Zusammenfassung     

Limiting zeros of decouplable MIMO systems

For sufficiently rapid zero-order hold (ZOH) sampling, it is known that the zeros of single-input/single-output discrete-time systems expressed in the forward shift operator converge to values determined only by the degrees of the finite and infinite zeros of the underlying continuous-time system. In this paper, it is shown how this result can be generalized to multi-input/multi-output (MIMO) systems decouplable by static-state feedback (equivalently, having a diagonal interactor matrix). In the fast sampling limit, the authors show how invariant and infinite zero structure is mapped under ZOH sampling for discrete-time systems expressed in either the delta (forward difference) or forward shift operators     

Low-frequency pulsed electromagnetic field exposure can alter neuroprocessing in humans

Extremely low-frequency magnetic fields (from DC to 300 Hz) have been shown to affect pain sensitivity in snails, rodents and humans. Here, a functional magnetic resonance imaging study demonstrates how the neuromodulation effect of these magnetic fields influences the processing of acute thermal pain in normal volunteers. Significant interactions were found between pre- and post-exposure activation between the sham and exposed groups for the ipsilateral (right) insula, anterior cingulate and bilateral hippocampus/caudate areas. These results show, for the first time, that the neuromodulation induced by exposure to low-intensity low-frequency magnetic fields can be observed in humans using functional brain imaging and that the detection mechanism for these effects may be different from those used by animals for orientation and navigation. Magnetoreception may be more common than presently thought.     

New developments in diagnosis and therapy of primary non-Hodgkin's lymphoma of the central nervous system

Primary central nervous system lymphomas (PCNSLs) are increasing in frequency both in immunocompetent and immunodeficient individuals. The majority of PCNSLs are high grade B cell lymphomas. In AIDS patients most tumors contain EBV genome. PCNSLs usually present as intracerebral, often deep-seated lesions half of which are multilocular. Less frequent are diffuse periventricular, exclusively leptomeningeal, ocular or spinal spread. On imaging PCNSLs show as contrast-enhancing lesions with relatively little perifocal edema. CSF protein is usually elevated. Malignant cells are present in 20-30% of cases. Demonstration of a monoclonal B cell population by immunocytology or FACS analysis may also be diagnostic. Once PCNSL is suspected extensive systemic evaluation is not useful. Instead, (stereotactic) biopsy of brain lesion(s) should be performed. Prior to biopsy, corticosteroids should be withheld as they may obscure diagnosis. Symptomatic edema or increased intracranial pressure should therefore initially be treated with osmotherapeutics. All immunodeficient patients should receive empiric anti-toxoplasmosis therapy for about 14 days prior to biopsy. AIDS patients with PCNSL survive 3 to 5 months (median) after whole brain irradiation and usually do not benefit from chemotherapy. Immunocompetent patients have a median survival of 12 to 18 months after whole brain irradiation alone, but a median survival of 33 to 43 months after combined radiochemotherapy using cytostatic drugs which penetrate the blood-brain barrier. Based on these encouraging results current concepts aim to intensify chemotherapy and to reduce or delay radiotherapy in the treatment of immunocompetent patients.