Tissue dynamics spectroscopy for three-dimensional tissue-based drug screening

Tissue dynamics spectroscopy combines dynamic light scattering with short-coherence digital holography to capture intracellular motion inside multicellular tumor spheroid tissue models. The cellular mechanical activity becomes an endogenous imaging contrast agent for motility contrast imaging. Fluctuation spectroscopy is performed on dynamic speckle from the proliferating shell and hypoxic core to generate drug-response spectrograms that are frequency versus time representations of the changes in spectral content induced by an applied compound or an environmental perturbation. A combination of 28 reference compounds and conditions applied to rat osteogenic UMR-106 spheroids generated spectrograms that were crosscorrelated in a similarity matrix used for unsupervised hierarchical clustering of similar compound responses. This work establishes the feasibility of tissue dynamics spectroscopy for three-dimensional tissue-based phenotypic profiling of drug response as a fully endogenous probe of the response of tissue to reference compounds.     

Real-time foveation filtering using nonlinear Mipmap interpolation

In recent years, several techniques have been proposed to simulate the gaze effect of the Human Visual System (HVS). It is believed that this effect is due to the foveation filtering. Current techniques to simulate the foveation filtering in computer graphics are either slow or suffer from artifacts and limitations. In this paper, we present a new approach of foveation filtering based on the Mipmap Pyramid of the current view by considering the relationship between the Gaussian kernel and Mipmap level. Due to the nonlinear Mipmap interpolation under the Bilateral Filtering scheme, we are able to simulate the foveation filtering more naturally and efficiently than in previous work. Moreover, a detail enhancement method based on the Cornsweet illusion is proposed to augment the gazing effect. We demonstrate our new approach with a variety of examples and provide comparisons with recent approaches.     

曲线梁桥计算理论与设计实践问题探讨

曲线梁桥以其良好的适应性和动态美感在我国桥梁设计界出现频率逐年增高,然而其安全隐患和运营事故也随之出现.就此状况,从研究曲线梁桥的力学性能入手,结合工程实际对现有计算理论和设计方法进行归纳与分析,提出其中有待进一步研究解决的问题,以期为曲线梁桥的设计与实践提供参考建议.     

E-learning2.0理念下传统网络学习系统的改造

随着Web2.0观念的提出,数字学习也有了e-learning2.0的概念。Web2.0的相关技术主要包括Wikis、Blogs、微博、社会化网络及书签等,因此可以将Web2.0的相关工具整合到传统e-learning1.0平台中,改造传统网络学习平台,从而在技术层面上实现e-leanning2.0的理念。     

基于UC3637的永磁直线电机控制系统

由于旋转电机和直线电机的结构不同,其控制系统也有很大差异。该文介绍了1种将无刷直流旋转电机专用芯片UC3637在直线电机控制系统的应用实例,介绍了硬件和软件结构以及实验结果和应用。     

基于GSI的交互式网格安全认证研究

网格认证是网格安全的重要组成部分,是对网格实体身份有效性进行确定的过程。网格环境下虚拟组织为认证提出了新的要求。介绍了网格环境下虚拟组织的特点,阐述了网格认证的基本要求,分析了几项常用的认证技术不适合多结点网格认证的原因,在此基础上分析了Globus项目中基于GSI认证的相关技术及概念。网格技术是一项不断发展的技术,网格认证也处于不断完善之中。     

火力发电厂工业冷却水系统工艺分析

从技术、经济和安全三个方面分析了采用不锈钢管材凝汽器的火力发电厂的工业冷却水系统，采用闭式循环工艺运行方式的合理性。