Effects of EGb 761 on nitric oxide and oxygen free radicals, myocardial damage and arrhythmia in ischemia-reperfusion injury in vivo

The cardioprotective effects of EGb 761 on the release of nitric oxide (NO), the concentration of serum thiobarbituric acid reaction substance (TBARS), the activity of creatine kinase (CK) and the incidence of ventricular arrhythmias were investigated in myocardial ischemia-reperfusion injury in vivo. Using sodium nitrite (NaNO2) as standard source of nitric oxide (NO), we compared the correlation coefficients of the three measuring methods used currently in the determination of NOFe2+(DETC)2 complex with that of the measuring method suggested in this study. The result showed that measuring the whole height of three splitting signals is the best linear correlation to the concentration of NO comparing with other methods in this system. Using this method, we observed the effects of EGb 761 on NOFe2+(DETC)2 complex in myocardial ischemia-reperfusion injury in vivo. The hearts of the Wistar rats were subjected to 30 min of ischemia and 10 min of reperfusion in vivo. Different doses of EGb 761 (25, 50, 100, 200 mg/kg i.p.), superoxide dismutase (SOD, 10(4) U/kg), l-arginine (50 mg/kg i.p.) and nitric oxide synthase (NOS) inhibitor NG-nitro-l-arginine (NNA, 50 mg/kg i.p.) were administered to the ischemia-reperfusion rats. EGb 761 under the dose of 100 mg/kg increased the signal intensity of NOFe2+(DETC)2 complex, while EGb 761 at 200 mg/kg showed an effect of decreasing the signal intensity of NOFe2+(DETC)2 complex. EGb 761 inhibited the formation of TBARS, the release of CK, and mitigated the incidence of ventricular arrhythmias in a dose dependent way. Both l-arginine and SOD increased the signal intensity of NOFe2+(DETC)2 complex and inhibited the formation of TBARS, the leakage of CK and the incidence of ventricular arrhythmia. NNA not only had no protective effects on myocardial injury, but also increased the incidence of reperfusion-induced arrhythmia. In conclusion, EGb 761 has cardiovascular protective effects by means of adjusting the level of NO and inhibiting oxygen free radicals induced lipid peroxidation in myocardial ischemia-reperfusion injury in vivo.     

Autonomic nervous activity at episodes of myocardial ischemia in patients with coronary artery disease by heart rate power spectral analysis

Heart rate power spectral analysis in 44 patients with coronary artery disease was obtained from 24-hour dynamic electrocardiogram. 195 episodes of transient myocardial ischemia that was defined as horizontal or down sloping depression of the ST segment of > or = 0.1 mV and lasted for > or = 2 minutes were studied. The area of low frequency components (LF, 0.02-0.10 Hz) representing predominontly sympathetic tone with some contribution from the parasympathetic tone and that of high frequency components (HF, 0.15-0.40 Hz) representing mainly parasympathetic tone and the value of LF/HF on 4 minute heart rate power spectral graph at the deepest depression of ST segment were compared with that before the episode of myocardial ischemia. The area of HF of fast rate myocardial ischemia occurring in night reduces significantly (P < 0.001), the value of LF/HF increases markedly (P < 0.05) and the area of LF increases slightly. The results suggest that there is a change of autonomic nervous activity during the episode of fast rate myocardial ischemia in night, parasympathetic nervous tone decreases markedly, there may be secondary increase of sympathetic nervous activity.     

折线链节点标注技术

针对传统多边形位置关系计算比较烦琐,以及简单多边形的理论难以拓展到一般多边形的问题,提出标注节点状态的方法.通过定义11种位置来描述折线链上每个节点的状态,再采用"线段端点与线段"和"线段端点与邻折线"的标注方法来实现任意折线链的标注,同时利用两线段分割预处理使相交仅发生在端点处,从而使算法更高效;然后给出折线链基本位置关系的节点特征,并且探讨了三维顶点的标注方法.该方法的标注原理简单、方法实用,算法空间和时间复杂度分别为O(n)和O(n2).实验结果表明,该方法对任意形状的折线链都能实现稳定标注;通过搜索节点状态特征可以求解折线链间的相互关系,还可以实现一般折线链的碰撞检测、相交区域计算以及多边形简单化分解等.     

基于区间树硬件加速索引的Marching Cubes算法

为了充分利用GPU的海量线程并行架构,提高等值面可视化效率,提出一种基于区间树硬件加速索引的Marching Cubes算法.该算法在预计算阶段利用GPU构造多区域的区间树作为体数据体素的值域索引;在实时运行阶段根据用户给定的阈值,通过该索引并行地搜索活跃体素,并生成活跃体素的多级索引,然后分配线程处理活跃体素,抽取并绘制等值面.将文中算法应用到不同体数据上的实验结果表明,其能够显著地提高现有Marching Cubes算法的效率;与现有的GPU基准算法相比,最高能达到4～10倍的加速比.     

MEMS惯性传感器ADIS16355在姿态测量中的应用

设计了基于微电子机械系统(Microelectro mechanical system,MEMS)惯性传感器集成模块ADIS16355的姿态测量系统。该姿态测量系统采用ADIS16355作为惯性测量单元,利用加速度计对重力向量的观测来修正陀螺给出的姿态信息,卡尔曼滤波实现传感器信息融合以计算运动载体的姿态角。介绍了ADIS16355的基本功能模块,阐述了两种传感器融合测量实时姿态角的方法并给出了卡尔曼滤波算法迭代过程。基于ARMv7架构的Cotex-M3微处理器设计了姿态测量系统硬件。采用AHRS500GA对该姿态测量系统性能进行了测量姿态角的验证实验。测试结果表明,该姿态测量系统能在动态条件下准确地测定运动物体实时姿态角,其误差一般在±1°左右。     

一种调整簇阀值的加速聚类分析算法及其应用

针对航运信息中大样本聚类问题,根据k-means聚类过程中大部分簇的调整发生在初始迭代阶段的特性,提出了一种调整簇阀值的加速聚类方法,并对该算法进行实例测试,实验结果证明了该方法在满足原有的聚类精度的基础上,减少了聚类的计算量。本文将该方法应用到船舶航线设计中。     

Learning Deep Patch representation for Probabilistic Graphical Model-Based Face Sketch Synthesis

International Journal of Computer Vision - Face sketch synthesis has a wide range of applications in both digital entertainment and law enforcement. State-of-the-art examplar-based methods...