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11.
Polymorphonuclear leucocyte (PMNL) accumulation in extravascular tissues and inflammatory exudates is dependent on their migration through blood vessel endothelium and then through connective tissue. Previously we utilized a barrier of human synovial and dermal fibroblasts (HSF or HDF) grown on microporous filters, as a model of PMNL migration through connective tissue. Those studies showed that beta 2 (CD18) and the beta 1 integrins, very late activation antigen-5 (VLA-5) and VLA-6, in part mediate this PMNL migration. Here we report that VLA-4, which can also be expressed at low levels on activated PMNL, is also involved in PMNL migration induced by C5a through fibroblast (HSF and HDF) barriers, because monoclonal antibody (mAb) to VLA-4 significantly inhibited (by 20-30%) PMNL migration. Blocking the function of CD18, VLA-5 or VLA-6 was not required for detection of the VLA-4-mediated migration. Combination treatment with mAb to VLA-4 and with mAb to VLA-5 or to VLA-6 further inhibited PMNL migration, irrespective of whether CD11/CD18 mechanisms were blocked with anti-CD18 mAb or not. Treatment of PMNL with a peptide based on the VLA-4-binding domain in the CS-1 fragment of fibronectin, but not a control peptide, inhibited PMNL migration to a comparable extent to treatment with mAb to VLA-4. A low level of VLA-4 was expressed on C5a-activated PMNL, detected by immunofluorescence flow cytometry. These results suggest that VLA-4 can be mobilized by human peripheral blood PMNL and can, in addition to VLA-5, VLA-6 and CD11/CD18 integrins, mediate PMNL migration through connective tissue. This is in marked contrast to PMNL transendothelial migration, where beta 1 integrins appear to play no significant role. 相似文献
12.
介绍了军用飞机电子吊舱蒸汽压缩制冷环境控制系统的工作特点,给出了电子膨胀阀在电子吊舱地面模拟制冷系统中的初步试验研究结果。 相似文献
13.
文章对非标准工况下的空分设备增产氩措施进行了研究。以宝钢6#60000m3/h空分设备为例,通过设计型算法和校核型算法,建立了空分设备精馏的数学模型,通过改变数学模型的参数,分析了在非标准工况下精馏塔内的组分浓度分布,并提出了优化后的操作方案和操作参数,实施后提高了空分设备的氩提取率,取得了显著的经济效益。 相似文献
14.
Chen J.J. Gao G.-B. Chyi J.-I. Morkoc H. 《Electron Devices, IEEE Transactions on》1989,36(10):2165-2172
Avalanche breakdown behavior at the collector junction of the GaAs/AlGaAs HBT (heterojunction bipolar transistor) has been studied. Junction breakdown characteristics displaying hard breakdown, soft breakdown, and negative resistance breakdown behavior were observed and are interpreted by analysis of localized microplasma effects, uniform microplasma-free behavior, and associated current gain measurements. Light emission from the collector-base junction of the GaAs/AlGaAs HBT was observed and used to investigate breakdown uniformity. Using a simple punchthrough breakdown model, the theoretical breakdown curves at different collector doping concentrations and thicknesses were computed and found to be in agreement with maximum breakdown voltages measured from devices displaying the most uniform junction breakdown. The serious current gain degradation of GaAs/AlGaAs HBTs at low current densities was analyzed in connection with the measurement of a large collector-emitter breakdown voltage. The unexpected functional relationship between the collector-emitter breakdown voltage and collector-base breakdown voltage is explained by the absence of a hole-feedback effect for devices not exhibiting transistor action 相似文献
15.
This study examined why Websites were co-linked using Canadian university Websites as the test set. Pages that co-linked to
these university Websites were located using Yahool. A random sample of 859 co-linking pages (the page that initiated the
co-link) was retrieved and the contents of the page, as well as the context of the link, were manually examined to record
the following variables: language, country, type of Website, and the reasons for co-linking. The study found that in over
94% of cases, the two co-linked universities were related academically; many of these cases (38%) showed a relationship specifically
in teaching or research. This confirms results, from previous quantitative studies, that Web co-links can be a measure of
the similarity or relatedness of sites being co-linked and that Web co-link analysis can thus be used to study relationships
among linked Websites. 相似文献
16.
研究了元素含量变化对8011铝合金防盗盖板综合性能的影响,在8011合金中改变Cu、Mn元素含量后可提高防盗盖板的强度,同时研究了烘烤处理后的强度变化问题。本文研究出了8011铝合金防盗盖板新的生产工艺制度。 相似文献
17.
研究了钒渣中钼与硫氰酸铵的显色反应,结果表明λmax=460nm,在0~50mg/50ml范围内吸光度与钼量的关系符合比尔定律,用于钒渣中钼的测定,结果令人满意。 相似文献
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20.
小秦岭地区金矿床严格受构造控制,各成矿阶段及矿物学特征明显,通过对矿物学特征的研究找出矿物学标志,认为今后找矿要注意各阶段石英的颜色、黄铁矿中金的含量以及矿石中银的含量,这些与金有密切关系. 相似文献