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21.
Cheng-Chin Huang Ching-Yao Yang Chin-Chuan Su Kai-Min Fang Cheng-Chieh Yen Ching-Ting Lin Jui-Min Liu Kuan-I Lee Ya-Wen Chen Shing-Hwa Liu Chun-Fa Huang 《International journal of molecular sciences》2021,22(9)
4-methyl-2,4-bis(4-hydroxyphenyl)pent-1-ene (MBP), a major active metabolite of bisphenol A (BPA), is generated in the mammalian liver. Some studies have suggested that MBP exerts greater toxicity than BPA. However, the mechanism underlying MBP-induced pancreatic β-cell cytotoxicity remains largely unclear. This study demonstrated the cytotoxicity of MBP in pancreatic β-cells and elucidated the cellular mechanism involved in MBP-induced β-cell death. Our results showed that MBP exposure significantly reduced cell viability, caused insulin secretion dysfunction, and induced apoptotic events including increased caspase-3 activity and the expression of active forms of caspase-3/-7/-9 and PARP protein. In addition, MBP triggered endoplasmic reticulum (ER) stress, as indicated by the upregulation of GRP 78, CHOP, and cleaved caspase-12 proteins. Pretreatment with 4-phenylbutyric acid (4-PBA; a pharmacological inhibitor of ER stress) markedly reversed MBP-induced ER stress and apoptosis-related signals. Furthermore, exposure to MBP significantly induced the protein phosphorylation of JNK and AMP-activated protein kinase (AMPK)α. Pretreatment of β-cells with pharmacological inhibitors for JNK (SP600125) and AMPK (compound C), respectively, effectively abrogated the MBP-induced apoptosis-related signals. Both JNK and AMPK inhibitors also suppressed the MBP-induced activation of JNK and AMPKα and of each other. In conclusion, these findings suggest that MBP exposure exerts cytotoxicity on β-cells via the interdependent activation of JNK and AMPKα, which regulates the downstream apoptotic signaling pathway. 相似文献
22.
Fluorescence‐Activated Cell Sorters: Standing Surface Acoustic Wave (SSAW)‐Based Fluorescence‐Activated Cell Sorter (Small 40/2018)
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23.
Salim Hengky K. Padfield Rory Lee Chew Tin Syayuti Khadijah Papargyropoulou Effie Tham Mun Hou 《Clean Technologies and Environmental Policy》2018,20(3):529-538
Clean Technologies and Environmental Policy - Food production and consumption is one of the major causes of global environmental degradation. One way to address environmental impacts in the food... 相似文献
24.
Lee Sangyul Kim Minjae Kim Hajin 《Journal of Mechanical Science and Technology》2018,32(12):5961-5972
Journal of Mechanical Science and Technology - The shape of the combustion chamber plays an important role in the formation of the air-fuel mixture in the chamber, which has a great influence on... 相似文献
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Multimedia Systems - The preferences of Web information purchasers are changing. Cost-effectiveness (i.e., an emphasis on performance with respect to price) is becoming less regarded than... 相似文献
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The Journal of Supercomputing - Spark is one of the most widely used systems for the distributed processing of big data. Its performance bottlenecks are mainly due to the network I/O, disk I/O, and... 相似文献
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SPEEK/cSMM membrane for simultaneous electricity generation and wastewater treatment in microbial fuel cell
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