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11.
Zahra Nasri Mohsen Ahmadi Johanna Striesow Mehdi Ravandeh Thomas von Woedtke Kristian Wende 《International journal of molecular sciences》2022,23(11)
As a new field of oxidative stress-based therapy, cold physical plasma is a promising tool for several biomedical applications due to its potential to create a broad diversity of reactive oxygen and nitrogen species (RONS). Although proposed, the impact of plasma-derived RONS on the cell membrane lipids and properties is not fully understood. For this purpose, the changes in the lipid bilayer functionality under oxidative stress generated by an argon plasma jet (kINPen) were investigated by electrochemical techniques. In addition, liquid chromatography-tandem mass spectrometry was employed to analyze the plasma-induced modifications on the model lipids. Various asymmetric bilayers mimicking the structure and properties of the erythrocyte cell membrane were transferred onto a gold electrode surface by Langmuir-Blodgett/Langmuir-Schaefer deposition techniques. A strong impact of cholesterol on membrane permeabilization by plasma-derived species was revealed. Moreover, the maintenance of the barrier properties is influenced by the chemical composition of the head group. Mainly the head group size and its hydrogen bonding capacities are relevant, and phosphatidylcholines are significantly more susceptible than phosphatidylserines and other lipid classes, underlining the high relevance of this lipid class in membrane dynamics and cell physiology. 相似文献
12.
Nathalie M. Malewicz Zahra Rattray Sebastian Oeck Sebastian Jung Vicente Escamilla-Rivera Zeming Chen Xiangjun Tang Jiangbing Zhou Robert H. LaMotte 《International journal of molecular sciences》2022,23(9)
Background: Capsaicin, the hot pepper agent, produces burning followed by desensitization. To treat localized itch or pain with minimal burning, low capsaicin concentrations can be repeatedly applied. We hypothesized that alternatively controlled release of capsaicin from poly(lactic-co-glycolic acid) (PLGA) nanoparticles desensitizes superficially terminating nociceptors, reducing burning. Methods: Capsaicin-loaded PLGA nanoparticles were prepared (single-emulsion solvent evaporation) and characterized (size, morphology, capsaicin loading, encapsulation efficiency, in vitro release profile). Capsaicin-PLGA nanoparticles were applied to murine skin and evaluated in healthy human participants (n = 21) for 4 days under blinded conditions, and itch and nociceptive sensations evoked by mechanical, heat stimuli and pruritogens cowhage, β-alanine, BAM8-22 and histamine were evaluated. Results: Nanoparticles (loading: 58 µg capsaicin/mg) released in vitro 23% capsaicin within the first hour and had complete release at 72 h. In mice, 24 h post-application Capsaicin-PLGA nanoparticles penetrated the dermis and led to decreased nociceptive behavioral responses to heat and mechanical stimulation (desensitization). Application in humans produced a weak to moderate burning, dissipating after 3 h. A loss of heat pain up to 2 weeks was observed. After capsaicin nanoparticles, itch and nociceptive sensations were reduced in response to pruritogens cowhage, β-alanine or BAM8-22, but were normal to histamine. Conclusions: Capsaicin nanoparticles could be useful in reducing pain and itch associated with pruritic diseases that are histamine-independent. 相似文献
13.
Zahra Shabeh tu Syed Waqar A.A. Rafiq Nouman Shah Wiqar H. Iqbal Zafar 《Protection of Metals and Physical Chemistry of Surfaces》2021,57(2):321-328
Protection of Metals and Physical Chemistry of Surfaces - Chromium oxide thin films were grown on Al2O3 substrates by ablating a pure Cr2O3 target using a KrF excimer laser. The energy density on... 相似文献
14.
A simple and fast method based on solid phase extraction (SPE) applying zinc oxide (ZnO) nanoparticles and atomic absorption spectrometry (AAS) was developed for the trace amount determination of silver (Ag) in aqueous samples. The method linearity was in the range of 14 to 700 ng mL?1. The extraction efficiency of Ag was greater than 98% and limit of detection (LOD) was 4.2 ng mL?1. The preconcentration factor was 200 and the relative standard deviation (RSD%) of the method was 3.7% (n = 6). 相似文献
15.
In this work a newly semi polar extraction phase of carboxylated multiwalled carbon nanotube (MWCNTs) reinforced sol-gel immobilized polypropylene hollow fiber was prepared by low temperature hydrothermal process. It is coupled with flame atomic absorption spectroscopy was employed in the extraction and determination of cobalt and cadmium ions in wastewaters. The main factors influencing the pre-concentration and extraction of the metal ions have been examined in detail. Detection limits obtained in this way for Co(II) and Cd(II) ions were 0.0186 and 0.024 ng mL?1, respectively. 相似文献
16.
A magnetic solid phase extraction was developed for preconcentration of Cu(II) as a 4-bromo-2-(2,4-dichloro-phenylimino)-phenol complex on Fe3O4/SiO2 nanoparticles prior to its determination by atomic absorption spectroscopy. The effect of different parameters influencing the formation of the Cu complex and the extraction efficiency of the Cu complex were studied. Under optimal conditions, the calibration graph showed linearity in the range of 0.946–700 µg L?1 (R2 = 0.9995) of Cu(II). The limit of detection and relative standard deviation of the method (n = 6) were 0.283 µg L?1 and 3.0%, respectively. The method was successfully applied to determine copper (II) in water samples. 相似文献
17.
In this article, a novel method for synthesis of 2-substituted benzimidazoles using MnO2 nanoparticles as a convenient oxidant agent in ethanol-water (1:1) as solvent under ultrasound irradiation was demonstrated. In this protocol the desired products were purely obtained in high yields. The main advantages of this research are: mild procedure, simplicity of method, easily work-up, high yields, and short reaction times. The MnO2 nanoparticles were synthesized through a solid-state reaction route using simple strarting materials. Furthermore, their structure was characterized by X-ray diffraction (XRD), scanning electron microscopy (SEM), and Fourier transform infrared spectroscopy (FT-IR). 相似文献
18.
The shared housing sector is a growing private rental submarket. Researchers have sought to analyse the drivers of this growth, the benefits of shared housing for tenants, landlords and wider urban systems, as well as risks for tenants and local planning systems. Yet, there is limited research exploring the diversity of the shared housing sector. In particular, analysis of room or space sharing with non-related adults is lacking. This paper explores the characteristics, geography and impact of room sharing across Sydney. By analysing online accommodation listings this paper provides insights for policymakers seeking to monitor and regulate shared room accommodation. 相似文献
19.
Velayati Mahin Sabouri Zahra Masoudi Abdolhossein Mostafapour Asma Khatami Mehrdad Darroudi Majid 《SILICON》2022,14(13):7541-7554
Silicon - In this research, epoxy polyurethane-nano silica nanocomposites have been synthesized using an in-situ method, for which SiO2 nanocomposites had been initially ready in N,... 相似文献
20.
The thermo-oxidative behavior of unformulated (unfilled) samples of epoxy coatings has been studied at five temperatures ranging from 70 °C to 150 °C. Two epoxy networks based on diglycidyl ether of bisphenol A (DGEBA), respectively, cured by jeffamine (POPA) or polyamidoamine (PAA) were compared. Infrared spectrophotometry (IR), differential scanning (DSC) and sol–gel analysis (SGA) were used to monitor structural changes. 相似文献