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排序方式: 共有173条查询结果,搜索用时 15 毫秒
21.
Yuanjing Lin Mallika Bariya Hnin Yin Yin Nyein Liisa Kivimki Sanna Uusitalo Elina Jansson Wenbo Ji Zhen Yuan Tuomas Happonen Christina Liedert Jussi Hiltunen Zhiyong Fan Ali Javey 《Advanced functional materials》2019,29(33)
Development of reliable glucose sensors for noninvasive monitoring without interruption or limiting users' mobility is highly desirable, especially for diabetes diagnostics, which requires routine/long‐term monitoring. However, their applications are largely limited by the relatively poor stability. Herein, a porous membrane is synthesized for effective enzyme immobilization and it is robustly anchored to the modified nanotextured electrode solid contacts, so as to realize glucose sensors with significantly enhanced sensing stability and mechanical robustness. To the best of our knowledge, this is the first report of utilizing such nanoporous membranes for electrochemical sensor applications, which eliminates enzyme escape and provides a sufficient surface area for molecular/ion diffusion and interactions, thus ensuring the sustainable catalytic activities of the sensors and generating reliable measureable signals during noninvasive monitoring. The as‐assembled nanostructured glucose sensors demonstrate reliable long‐term stable monitoring with a minimal response drift for up to 20 h, which delivers a remarkable enhancement. Moreover, they can be integrated into a microfluidic sensing patch for noninvasive sweat glucose monitoring. The as‐synthesized nanostructured glucose sensors with remarkable stability can inspire developments of various enzymatic biosensors for reliable noninvasive composition analysis and their ultimate applications in predictive clinical diagnostics, personalized health‐care monitoring, and chronic diseases management. 相似文献
22.
从业十五载,从生产、行政到设计,多重身份的转变让他对珠宝有了更多的认识。以精巧细致追求完美,以灵动设计谋求共鸣。本期,就让我们跟随笔者的脚步,共同走近珠宝追梦人——黄颖聪的珠宝世界。梦幻宝石在黄颖聪的众多设计作品中,亚历山大变石可谓“常客”。 相似文献
23.
24.
Lassi Koski Cecilia Ronnevi Elina Berntsson Sebastian K. T. S. Wrmlnder Per M. Roos 《International journal of molecular sciences》2021,22(22)
Amyotrophic lateral sclerosis (ALS), Alzheimer’s disease, Parkinson’s disease and similar neurodegenerative disorders take their toll on patients, caregivers and society. A common denominator for these disorders is the accumulation of aggregated proteins in nerve cells, yet the triggers for these aggregation processes are currently unknown. In ALS, protein aggregation has been described for the SOD1, C9orf72, FUS and TDP-43 proteins. The latter is a nuclear protein normally binding to both DNA and RNA, contributing to gene expression and mRNA life cycle regulation. TDP-43 seems to have a specific role in ALS pathogenesis, and ubiquitinated and hyperphosphorylated cytoplasmic inclusions of aggregated TDP-43 are present in nerve cells in almost all sporadic ALS cases. ALS pathology appears to include metal imbalances, and environmental metal exposure is a known risk factor in ALS. However, studies on metal-to-TDP-43 interactions are scarce, even though this protein seems to have the capacity to bind to metals. This review discusses the possible role of metals in TDP-43 aggregation, with respect to ALS pathology. 相似文献
25.
Bettina Grauel Christian Würth Christian Homann Lisa Krukewitt Elina Andresen Janina Roik Sebastian Recknagel Markus Haase Ute Resch-Genger 《Nano Research》2022,(3):2362-2373
Despite considerable advances in synthesizing high-quality core/shell upconversion(UC)nanocrystals(NC;UCNC)and UCNC photophysics,the application of near-infrare... 相似文献
26.
Vladimir A. Dyakonov Ilgiz I. Islamov Lilya U. Dzhemileva Elina Kh. Makarova Usein M. Dzhemilev 《International journal of molecular sciences》2021,22(16)
An original synthetic route was developed for the preparation of previously unknown unsaturated polyaromatic macrolactones containing a 1Z,5Z-diene moiety in 48–71% yields and with >98% stereoselectivity. The method is based on intermolecular cyclocondensation of aromatic dicarboxylic acids with α,ω-alka-nZ,(n+4)Z-dienediols (1,12-dodeca-4Z,8Z-dienediol, 1,14-tetradeca-5Z,9Z-dienediol, 1,18-octadeca-7Z,11Z-dienediol) mediated by N-(3-dimethylaminopropyl)-N′-ethylcarbodiimide hydrochloride (EDC)/4-dimethylaminopyridine (DMAP). The unsaturated diols were prepared by successive homo-cyclomagnesiation of tetrahydropyran ethers of O-containing 1,2-dienes with EtMgBr in the presence of Mg metal and the Cp2TiCl2 catalyst (10 mol.%) and subsequent treatment with 0.1 equiv. of para-toluenesulfonic acid of pyran ethers formed after the acid hydrolysis of magnesacyclopentanes. The resulting cyclophanes exhibited high cytotoxic activity in vitro against Jurkat, K562, U937, and HL60 cancer lines. Additionally, the synthesized products were studied for their effect on mitochondria, ability to induce apoptosis, and influence on the cell cycle using modern flow cytometry methods. 相似文献
27.
Natthorn Intawiwat Elina Myhre Harry Øysæd Svein H. Jamtvedt Marit Kvalvåg Pettersen 《Polymer Engineering and Science》2012,52(9):2015-2024
Packaging material with optimal light barrier properties can prevent food quality deterioration. For dairy products, wavelength in the visible region between 400–450 nm and 600–650 nm should be blocked out due to the content of chlorophyll in dairy products. Six low density polyethylene blown films were formulated with the combination of four different pigments and additives: green, yellow, silver additive, and optical brightener, in addition to four reference samples. All films were transparent. Optical properties and light transmission were measured for each film, and microscopy analyses were used to investigate the surface topography. The sample containing high concentration of both green and yellow pigments had the lowest value in gloss and transmittance. This film blocked the light below 450 nm and transmitted 10% at 600–650 nm. Optical brightener had an effect only on visual appearance but not on light transmission properties. Samples containing silver additive were more intense green and gave a higher light transmission in blue region (380–500 nm) and lower in red region (600–700 nm) compared with samples without silver additive. These developed films can be applied in dairy products and other food products in the future. POLYM. ENG. SCI., 52:2015–2024, 2012. © 2012 Society of Plastics Engineers 相似文献
28.
Singhal R Orynbayeva Z Kalyana Sundaram RV Niu JJ Bhattacharyya S Vitol EA Schrlau MG Papazoglou ES Friedman G Gogotsi Y 《Nature nanotechnology》2011,6(1):57-64
Glass micropipettes, atomic force microscope tips and nanoneedles can be used to interrogate cells, but these devices either have conical geometries that can damage cells during penetration or are incapable of continuous fluid handling. Here, we report a carbon-nanotube-based endoscope for interrogating cells, transporting fluids and performing optical and electrochemical diagnostics at the single organelle level. The endoscope, which is made by placing a multiwalled carbon nanotube (length, 50-60?μm) at the tip of a glass pipette, can probe the intracellular environment with a spatial resolution of ~100?nm and can also access organelles without disrupting the cell. When the nanotube is filled with magnetic nanoparticles, the endoscope can be remotely manoeuvered to transport nanoparticles and attolitre volumes of fluids to and from precise locations. Because they are mounted on conventional glass micropipettes, the endoscopes readily fit standard instruments, creating a broad range of opportunities for minimally invasive intracellular probing, drug delivery and single-cell surgery. 相似文献
29.
Pekka Manninen Elina H?iv?l? Seppo Sarimo H. Kallio 《Zeitschrift für Lebensmitteluntersuchung und -Forschung A》1997,204(3):202-205
The distribution of vegetative microbial cells and their spores in a supercritical CO2 extraction process was studied. The seed and flesh/skin fractions of the press residue of sea buckthorn berries (Hippopha? rhamnoides) from a juice factory were used as raw materials. A pilot-scale extraction plant was operated at 30 MPa at temperatures of
40 and 60°C. The number of yeasts, moulds and bacteria in the pulp/skin fraction, in the extraction residues, in the extracted
oils as well as in the water phases separated from the extracted oils was estimated by the spread plate technique. The microbial
content of the flesh/skin material was increased in some extractions by the addition of bacterial spores. In general, the
extraction process led to a decrease in the bacterial count of the extracted material, whereas no microbial growth was detected
in the oils extracted or in the water phases separated from them. Neither yeasts nor moulds were found in any samples after
the extraction process. The microbial status of seed oil and flesh/skin oil obtained by industrial-scale CO2 extraction at 40°C and at 30 MPa before and after gelatine encapsulation remained unchanged. This proves that supercritical
CO2 can be used to manufacture edible oil products free of living micro-organisms and their spores.
Received: 14 May 1996 相似文献
30.
The present level of the development of water/wastewater treatment methods, including advanced oxidation processes, allows removal of pollutants of wide spectrum under no question. However, the overall process cost and, especially, associated energy consumption are of increased importance. The present review presents the energy cost calculations made for the pollutants removal reported in more than forty publications for over the last four decades. Phenol, glycols, methyl-tert-butyl ether (MTBE), aliphatic unsaturated compounds, humic acids and lignin were considered as water pollutants for economic evaluation of their removal. Two oxidation processes, ozonation and Fenton reaction, were chosen as water treatment methods. 相似文献