Biodegradable Polymeric Nanoparticles Containing an Immune Checkpoint Inhibitor (aPDL1) to Locally Induce Immune Responses in the Central Nervous System

Immunotherapy is an efficient approach to clinical oncology. However, the immune privilege of the central nervous system (CNS) limits the application of immunotherapeutic strategies for brain cancers, especially glioblastoma (GBM). Tumor resistance to immune checkpoint inhibitors is a further challenge in immunotherapies. To overcome the immunological tolerance of brain tumors, a novel multifunctional nanoparticle (NP) for highly efficient synergetic immunotherapy is reported. The NP contains an anti-PDL1 antibody (aPDL1), upconverting NPs, and the photosensitizer 5-ALA; the surface of the NP is conjugated with the B1R kinin ligand to facilitate transport across the blood-tumor-barrier. Upon irradiation with a 980 nm laser, 5-ALA is transformed into protoporphyrin IX, generating reactive oxygen species. Photodynamic therapy (PDT) further promotes intratumoral infiltration of cytotoxic T lymphocytes and sensitizes tumors to PDL1 blockade therapy. It is demonstrated that combining PDT and aPDL1 can effectively suppress GBM growth in mouse models. The proposed NPs provide a novel and effective strategy for boosting anti-GBM photoimmunotherapy.     

Targeted Delivery of Anesthetic Agents to Bone Tissues using Conductive Microneedles Enhanced Iontophoresis for Painless Dental Anesthesia

Pain management during dental procedures is a cornerstone for successful daily practice. In current practice, the traditional needle and syringe injection is used to administer local anesthesia. However, the appearance of long needles and the pain associated with it often leads to dental anxiety deterring timely interventions. Microneedles (MNs) have emerged as a minimally invasive alternative to hypodermic needles and shown to be effective in transdermal drug delivery applications. In this article, the potential use of MNs for local anesthesia delivery in dentistry is explored. The development of a novel conductive MN array that can be used in combination with iontophoresis technique to achieve drug penetration through the oral mucosa and the underlying bone tissue is presented. The conductive MN array plays a dual-role, creating micro-conduits and lowering the resistance of the oral mucosa. The reduced tissue resistance further enhances the application of a low-voltage current that is able to direct and accelerate the drug molecules to target the sensory nerves supplying teeth. The successful delivery of lidocaine using this new strategy in a clinically relevant rabbit incisor model is shown to be as effective as the current gold standard.     

嵌入式Linux下S3C2410的调色板彩色显示

嵌入式应用中,由于计算能力以及硬件资源的限制,常需要降低颜色深度,以获得较高的分辨率,因此调色板彩色显示是一种很重要的手段。在此以ARM9核的S3C2410芯片为例,探讨分析调色板的概念及配置方法,通过修改驱动程序,实现了调色板彩色显示,给出了编程实例,总结了实现方法。试验表明,当LCD分辨率较高时,采用调色板彩色显示,解决了屏幕抖动和不连贯现象的发生。     

集成仿真系统中时间一致性问题分析

在实验室射频-数学集成仿真系统构建的基础上,对仿真系统集成过程中面对的时间一致性问题进行了理论研究,从仿真系统的时间分辨率、时间源和时间推进机制三方面详细分析了导致时间不一致原因,最后在深入分析的基础上,提出了解决时间不一致问题的方法。     

基于改进Sammon映射的辐射源个体特征有效性分析

Sammon映射算法将特征数据从高维映射到低维可视空间,并保持了高维空间中数据样本点之间的距离,可以对数据特征的有效性进行直观的可视化研究。利用自组织映射对特征数据的样本数量进行压缩预处理,降低Sammon算法的计算量,由此提出了改进型的SOSammon算法。通过对实测数据的分析表明,改进算法速度上优于原始算法,能够较好显示个体特征的散布特性。     

计算两不同平行轴间距柱形电容器电容的保角变换法

介绍了保角变换法,利用保角变换中常用的对数变换和分式变换,分别计算了不同平行轴间距的柱形电容器的电容,并进行了讨论。结果表明,当两轴间距离平方等于内外圆柱半径平方之和的2倍时,电容器的电容与同轴电容器是等效的;当两轴间距分别为大于内外半径之和,或小于内外半径之差时,两种情况下,两轴间距的平方之和等于内外圆柱半径平方之和的2倍时,两种电容器的电容等效。     

基于WiFi Halow的无线工业物联网应用

文章首先阐述了WiFi Halow技术内涵,分析了WiFi Halow技术的应用优势及其前景,最后重点探讨了基于WiFi Halow的无线工业物联网应用,以期为WiFi Halow技术在无线工业物联网中的高质量发展提供参考.     

基于移动端与电脑端互补模式的“计算机基础”课程教学改革

为培养计算机人才,适应时代的需求,计算机相关课程在各高校推广开来。文章主要探讨了“计算机基础”课程的发展进程以及该课程教学内容和形式,介绍了当前形势下所采用的移动端学习通与电脑端万维自动化考试系统相结合的教学模式及效果。     

增益与光强的相关系数对光栅外腔半导体激光器稳态特性的影响

本文引入增益与光强的相关系数h,建立了光栅外腔半导体激光器的稳态模型。数值计算结果表明:激光器的其它参数必须与h相匹配,才能使激光输出的稳定区增大,且可在一定波长范围内进行选频,保证很好的单模性。     

氮激光诱导荧光光谱法对动脉粥样硬化斑块的诊断研究

采用波长为337nm的N_2分子激光作光源,利用激光诱导荧光光谱法测量血管组织的自荧光,选择波长为390nm和476nm处的荧光强度比值可以很好地鉴别动脉血管的正常组织和粥样硬化斑块,阈值为1.25。