Graph-Theoretic Method on Topology Identification of Stochastic Multi-weighted Complex Networks with Time-Varying Delayed Coupling Based on Adaptive Synchronization

Neural Processing Letters - This paper is concerned with topology identification of stochastic multi-weighted complex networks based on adaptive synchronization. Different from previous work,...     

Evaluation of the PSMA-Binding Ligand 212Pb-NG001 in Multicellular Tumour Spheroid and Mouse Models of Prostate Cancer

Radioligand therapy targeting the prostate-specific membrane antigen (PSMA) is rapidly evolving as a promising treatment for metastatic castration-resistant prostate cancer. The PSMA-targeting ligand p-SCN-Bn-TCMC-PSMA (NG001) labelled with ²¹²Pb efficiently targets PSMA-positive cells in vitro and in vivo. The aim of this preclinical study was to evaluate the therapeutic potential of ²¹²Pb-NG001 in multicellular tumour spheroid and mouse models of prostate cancer. The cytotoxic effect of ²¹²Pb-NG001 was tested in human prostate C4-2 spheroids. Biodistribution at various time points and therapeutic effects of different activities of the radioligand were investigated in male athymic nude mice bearing C4-2 tumours, while long-term toxicity was studied in immunocompetent BALB/c mice. The radioligand induced a selective cytotoxic effect in spheroids at activity concentrations of 3–10 kBq/mL. In mice, the radioligand accumulated rapidly in tumours and was retained over 24 h, while it rapidly cleared from nontargeted tissues. Treatment with 0.25, 0.30 or 0.40 MBq of ²¹²Pb-NG001 significantly inhibited tumour growth and improved median survival with therapeutic indexes of 1.5, 2.3 and 2.7, respectively. In BALB/c mice, no signs of long-term radiation toxicity were observed at activities of 0.05 and 0.33 MBq. The obtained results warrant clinical studies to evaluate the biodistribution, therapeutic efficacy and toxicity of ²¹²Pb-NG001.     

某水利枢纽工程纵向围堰坝段混凝土温控防裂要点研究

水利枢纽工程中,纵向围堰坝段作为永久性挡水建筑物,两个侧面分别具有提前挡水和长期暴露的特点,开裂风险较大,需要有针对性的防裂措施。以某水利枢纽工程混凝土纵向围堰坝段为例,采用有限元仿真的分析方法,就其过流面、暴露面温控防裂要点进行重点分析。结果表明:无温控措施时,侧面最大应力达2. 82 MPa,安全系数仅为0. 59;设置纵缝及24℃中期冷却后,过流面、暴露面最大应力分别为1. 22 MPa、1. 18 MPa,安全系数分别为1. 37、1. 41;进一步对过流侧进行25. 00 m高程以下堆渣、对暴露侧进行保温后,过流面、暴露面最大应力分别降低为0. 85 MPa、0. 71MPa,安全系数分别提高到1. 96、2. 35,均满足1. 65的设计标准。因此,对于提前过流侧面的针对性防裂措施为,设置纵缝、过流侧过流前中期冷却及堆渣;暴露面一侧由于长期暴露,易遭遇寒潮影响,其主要防裂措施为,设置纵缝、中期冷却及保温。     

单榫头叶片叶身精锻成形规律

利用自行开发的叶片锻造过程三维刚粘塑性有限元模拟系统对单榫头叶片精锻过程进行了模拟分析,揭示了其叶身精锻成形规律,并以塑泥为模拟材料,采用物理模拟的方法对其进行了试验验证。三维有限元数值模拟结果与物理模拟结果的良好吻合表明了单榫头叶片精锻过程三维数值模拟结果的可靠性。该研究对叶片精锻过程的预成形毛坯的优化设计具有重要的指导意义。     

An improved proportionate least mean <Emphasis Type="Italic">p</Emphasis>-power algorithm for adaptive filtering

The least mean p-power error criterion has been successfully used in adaptive filtering due to its strong robustness against large outliers. In this paper, we develop a new adaptive filtering algorithm, named the proportionate least mean p-power (PLMP) algorithm, which uses the mean p-power error as the adaptation cost function. Compared with the standard proportionate normalized least mean square algorithm, the PLMP can achieve much better performance in terms of the mean square deviation, especially in the presence of impulsive non-Gaussian noises. The mean and mean square convergence of the proposed algorithm are analyzed, and some related theoretical results are also obtained. Simulation results are presented to verify the effectiveness of our proposed algorithm.     

适用于三维有限元网格显示的逐步消隐法

在分析现有消隐方法及三维有限元网格划分特点的基础上,提出了一种将外法线法与线面比较法相结合的消隐方法──逐步消隐法,快速有效地实现了三维网格的可视化。结果表明,用于三维有限元网格划分的消隐是简便实用的。     

临坡条形基础下地基极限承载力多因素影响规律的数值分析

为了系统分析边坡对临坡基础极限承载力的影响,采用控制变量法和FLAC3D有限差分软件,分别针对不同坡顶距、坡角、相对密实度、基底宽度的荷载-位移曲线,研究了极限承载力、极限承载力弱化系数、极限承载力系数的多因素演化规律。结果表明:极限承载力、极限承载力弱化系数、极限承载力系数随坡顶距增加而增大,当坡顶距b与基底宽度B之比大于5时增长趋于停滞,但未达到平地地基数值;地基极限承载力、弱化系数随坡角增加近似线性减小,变化速率基本不受坡顶距的影响;地基极限承载力、极限承载力系数随砂土相对密实度增加而增大,同时受到坡顶距的影响,大坡顶距下随相对密实度的变化速率高于小坡顶距;地基极限承载力受基底宽度的影响程度小于坡顶距,随基底宽度增加小幅度增大,极限承载力系数随基底宽度的增大而减小;地基极限承载力弱化系数对相对密实度、基底宽度不敏感;减小坡角、提高相对密实度与增大坡顶距对极限承载力的提高有类似的效果,单纯通过增大坡顶距仍不能达到接近平地极限承载力的水平,适当地减小坡角、增加相对密实度可增大接近平地地基极限承载力的可能性。研究结果可为临坡工程施工方案选择提供借鉴,对推动临坡地基的工程定量计算具有重要作用。     

库水位升降作用下锦屏一级水电站左岸边坡地下水渗流特征研究

为了研究锦屏一级水电站蓄水过程中库水位变化对边坡地下水渗流特征的影响,将左岸边坡构建精细的地质模型,并以饱和—非饱和渗流理论为基础,应用Geostudio Seep/W分别对5个库水位升降工况进行数值计算。结果表明:当库水位上升时,地下水渗流方向会由指向坡外变为指向坡内,而坡表的孔隙水压力首先增大,浸润线呈现出上凹的特征。当库水位下降时,地下水渗流方向会由指向坡内变为指向坡外,坡表的孔隙水压力快速减小,浸润线呈现出下凹的特征。而无论是库水位下降还是上升,岸坡内的渗流场变化始终会滞后于库水位的变化。产生这种滞后现象的原因与库水位升降速率和坡体渗透系数的大小有关。当渗透系数小于升降速率时,渗流场的动态变化就会产生滞后现象,并且库水位升降速率越快这种滞后现象越明显。     

考虑黏聚力损失的岩石残余强度模型与数值验证

岩石的峰后力学性质对于维持岩土工程结构的稳定性至关重要,为研究岩石峰后残余强度的确定方法,利用岩石进入残余强度阶段后摩擦力强度增强、黏聚力强度减小的特点,通过假定岩石进入残余变形阶段后黏聚力强度为0,基于HOEK-BROWN破坏准则,建立了一种考虑岩石进入残余强度阶段时黏聚力损失的岩石残余强度模型。用该模型拟合完整粗晶大理岩的室内三轴试验结果,并与已有M-C模型和Joseph模型等方法对比分析,讨论了模型的优势。将该模型嵌入到FLAC3D软件中进行数值模拟验证,结果表明:该岩石残余强度模型能正确反映不同围压条件下岩石力学响应的基本规律,得到的残余强度值与试验结果吻合良好,其随围压变化的拟合曲线符合试验数据拟合结果的特点,即经过原点及高围压条件下未出现应变硬化现象。研究成果对分析岩石残余强度的确定方法具有较强的参考价值或指导意义。     

丹江口水库汛期水位动态控制方案研究

丹江口水库加高完成后,为保障汉江中下游防洪安全和南水北调供水的顺利进行,防洪和蓄水的矛盾更加突出,根据目前的蓄水方案,蓄满率可能进一步降低。以62 a实测洪水资料为输入,对丹江口水库的运行方式进行了模拟调度和预泄能力分析,并根据汉江流域洪水特性,提出了不同时期丹江口水库的运行水位动态控制方案。根据提出的运行方案,丹江口水库在保证各项设计功能正常发挥的前提下,可进一步挖掘水库的防洪效益,并做到风险可控,供水保证率可提高10%左右,发电效益可增加5%左右。