An exploratory study of the impact of antipatterns on class change- and fault-proneness

Antipatterns are poor design choices that are conjectured to make object-oriented systems harder to maintain. We investigate the impact of antipatterns on classes in object-oriented systems by studying the relation between the presence of antipatterns and the change- and fault-proneness of the classes. We detect 13 antipatterns in 54 releases of ArgoUML, Eclipse, Mylyn, and Rhino, and analyse (1) to what extent classes participating in antipatterns have higher odds to change or to be subject to fault-fixing than other classes, (2) to what extent these odds (if higher) are due to the sizes of the classes or to the presence of antipatterns, and (3) what kinds of changes affect classes participating in antipatterns. We show that, in almost all releases of the four systems, classes participating in antipatterns are more change-and fault-prone than others. We also show that size alone cannot explain the higher odds of classes with antipatterns to underwent a (fault-fixing) change than other classes. Finally, we show that structural changes affect more classes with antipatterns than others. We provide qualitative explanations of the increase of change- and fault-proneness in classes participating in antipatterns using release notes and bug reports. The obtained results justify a posteriori previous work on the specification and detection of antipatterns and could help to better focus quality assurance and testing activities.     

On the generalized successive approximations method

In this paper, denoted a continuous function from [0,1]² into [0,1] by f, we consider the iterative process:

Health resort treatment of eye diseases caused by ischemia]

The authors discuss the results of ophthalmodynamometric tests used for the assessment of cerebro-retinal vessels reactivity following carbon dioxide baths and "peat collars". An analysis of systemic and local blood pressure in the ophthalmic artery measured with Weigelin and Lobstein technique enables to assess changes in blood pressures following a/m balneologic procedures. It was found that blood pressure does not change parallelly due to the mechanism of cerebral autoregulation. Transient decrease in blood pressure in the ophthalmic artery is produced by the dilatation of the internal carotid artery indicating a potent vasodilating action of carbon dioxide.     

现代化多星座卫星导航系统性能分析研究

卫星定位系统因其全球性、全天候、高精度等优点而被广泛应用。然而单一卫星导航系统在地球特殊区域存在可见星数目有限,卫星几何构形不佳等问题。针对上述问题,结合各系统未来更新状况,提出使用MATLAB软件进行星座仿真,分析了北斗、GPS III、GLONASS、GALILEO各系统区域定位的局限性,并利用最小二乘法将四个系统进行组合,从可见星数目和GDOP值两方面对组合系统与单一系统展开性能比较。仿真结果表明,组合星座系统能够明显增加可见星数目,改善单一星座区域GDOP值,提高定位精度。     

曲线运动SAR成像算法研究

研究合成孔径雷达曲线运动时的优化成像质量问题。提出了一种结合了惯导加速度参数和根据回波数据两种运动补偿曲线运动合成孔径雷达成像算法,提高了成像质量。首先研究了合成孔径雷达曲线运动时的目标模型,分析了惯性导航系统的原理,并以频谱分析的子孔径成像为基础,加入运动补偿等辅助处理。进行仿真,根据一组仿真参数和曲线轨迹生成仿真回波数据,证明仿真成像算法的有效性。系统运算简单,可为曲线运动时的合成孔径雷达实时信号处理系统系统设计提供依据。     

Temperature dependence of resistivity for thermally diffused V3Si multilayer films

Results concerning V₃Si films produced by a simple annealed multilayer technique are reported together with X-ray diffraction patterns, Auger spectroscopy, and Rutherford backscattering analysis. Low-temperature electrical resistivity measurements are discussed. It is found that the V₃Si films exhibit aT ² dependence in the temperature rangeT _c T23 K and aT ^2.6 dependence in the rangeT _c T40 K. The normal-state resistivity in the whole temperature range (T _c T600 K) is analyzed in the framework of Cote-Meisel theory. Consistent values of the saturation resistivity _m and of the Debye temperature are obtained by fitting the experimental data with the Cote-Meisel expression for (T).     

基于数据挖掘的焊接生产管理平台

焊接生产规模不断向自动化和流水线方式发展 ,对生产管理水平提出了更高的要求。为了从车间已积累的大量的生产历史数据中获得潜在的规律性和趋势 ,为管理者提供决策支持 ,文中在已有的质量在线监测平台和数据库系统上开发了基于先进的数据挖掘技术的焊接生产管理平台 ,同时为了获得有效的挖掘模式 ,对数据进行了预处理 ,建立了焊接车间数据集市。该平台主要使用控制图控制焊接生产产量和废品数量 ;利用决策树方法分析废品产生因素 ,获得了有效的挖掘模型 ,对于指导焊接生产具有重要意义     

环磺酮代谢物合成工艺研究

针对环磺酮代谢物开展制备工艺研究.以环磺酮为原料,经拜耳-维利格氧化重排等反应制备得到3个代谢物,含量均大于98.5％,满足用于农药登记、农残质检等领域的应用,极具社会应用价值.     

Effect of Polyhexamethylene Biguanide in Combination with Undecylenamidopropyl Betaine or PslG on Biofilm Clearance

Hospital-acquired infection is a great challenge for clinical treatment due to pathogens’ biofilm formation and their antibiotic resistance. Here, we investigate the effect of antiseptic agent polyhexamethylene biguanide (PHMB) and undecylenamidopropyl betaine (UB) against biofilms of four pathogens that are often found in hospitals, including Gram-negative bacteria Pseudomonas aeruginosa and Escherichia coli, Gram-positive bacteria Staphylococcus aureus, and pathogenic fungus, Candida albicans. We show that 0.02% PHMB, which is 10-fold lower than the concentration of commercial products, has a strong inhibitory effect on the growth, initial attachment, and biofilm formation of all tested pathogens. PHMB can also disrupt the preformed biofilms of these pathogens. In contrast, 0.1% UB exhibits a mild inhibitory effect on biofilm formation of the four pathogens. This concentration inhibits the growth of S. aureus and C. albicans yet has no growth effect on P. aeruginosa or E. coli. UB only slightly enhances the anti-biofilm efficacy of PHMB on P. aeruginosa biofilms. However, pretreatment with PslG, a glycosyl hydrolase that can efficiently inhibit and disrupt P. aeruginosa biofilm, highly enhances the clearance effect of PHMB on P. aeruginosa biofilms. Meanwhile, PslG can also disassemble the preformed biofilms of the other three pathogens within 30 min to a similar extent as UB treatment for 24 h.     

The GAUGAA Motif Is Responsible for the Binding between circSMARCA5 and SRSF1 and Related Downstream Effects on Glioblastoma Multiforme Cell Migration and Angiogenic Potential

Circular RNAs (circRNAs) are a large class of RNAs with regulatory functions within cells. We recently showed that circSMARCA5 is a tumor suppressor in glioblastoma multiforme (GBM) and acts as a decoy for Serine and Arginine Rich Splicing Factor 1 (SRSF1) through six predicted binding sites (BSs). Here we characterized RNA motifs functionally involved in the interaction between circSMARCA5 and SRSF1. Three different circSMARCA5 molecules (Mut1, Mut2, Mut3), each mutated in two predicted SRSF1 BSs at once, were obtained through PCR-based replacement of wild-type (WT) BS sequences and cloned in three independent pcDNA3 vectors. Mut1 significantly decreased its capability to interact with SRSF1 as compared to WT, based on the RNA immunoprecipitation assay. In silico analysis through the “Find Individual Motif Occurrences” (FIMO) algorithm showed GAUGAA as an experimentally validated SRSF1 binding motif significantly overrepresented within both predicted SRSF1 BSs mutated in Mut1 (q-value = 0.0011). U87MG and CAS-1, transfected with Mut1, significantly increased their migration with respect to controls transfected with WT, as revealed by the cell exclusion zone assay. Immortalized human brain microvascular endothelial cells (IM-HBMEC) exposed to conditioned medium (CM) harvested from U87MG and CAS-1 transfected with Mut1 significantly sprouted more than those treated with CM harvested from U87MG and CAS-1 transfected with WT, as shown by the tube formation assay. qRT-PCR showed that the intracellular pro- to anti-angiogenic Vascular Endothelial Growth Factor A (VEGFA) mRNA isoform ratio and the amount of total VEGFA mRNA secreted in CM significantly increased in Mut1-transfected CAS-1 as compared to controls transfected with WT. Our data suggest that GAUGAA is the RNA motif responsible for the interaction between circSMARCA5 and SRSF1 as well as for the circSMARCA5-mediated control of GBM cell migration and angiogenic potential.