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41.
Carmelo Gurnari Maria Teresa Voso Katia Girardi Angela Mastronuzzi Luisa Strocchio 《International journal of molecular sciences》2021,22(2)
Acute promyelocytic leukemia (APL) represents a paradigm of precision medicine. Indeed, in the last decades, the introduction of all-trans retinoic acid (ATRA) and arsenic trioxide (ATO) completely revolutionized the therapeutic approach to this previously highly fatal disorder. This entirely chemotherapy-free treatment, which provided excellent survival rates, has been initially validated in adults and, recently, translated in the pediatric setting. This review summarizes currently available data on the use of ATRA and ATO combination in pediatric APL, providing a particular focus on peculiar issues and challenges, such as the occurrence of pseudotumor cerebri and death during induction (early death), as well as the advantage offered by the ATO/ATRA combination in sparing long-term sequelae. 相似文献
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Andres Jimenez-Ramirez Irene Barba Juan Fernandez-Olivares Carmelo Del Valle Barbara Weber 《Knowledge and Information Systems》2018,57(3):655-684
Process-aware information systems (PAISs) are increasingly used to provide flexible support for business processes. The support given through a PAIS is greatly enhanced when it is able to provide accurate time predictions which is typically a very challenging task. Predictions should be (1) multi-dimensional and (2) not based on a single process instance. Furthermore, the prediction system should be able to (3) adapt to changing circumstances and (4) deal with multi-perspective declarative languages (e.g., models which consider time, resource, data and control flow perspectives). In this work, a novel approach for generating time predictions considering the aforementioned characteristics is proposed. For this, first, a multi-perspective constraint-based language is used to model the scenario. Thereafter, an optimized enactment plan (representing a potential execution alternative) is generated from such a model considering the current execution state of the process instances. Finally, predictions are performed by evaluating a desired function over this enactment plan. To evaluate the applicability of our approach in practical settings we apply it to a real process scenario. Despite the high complexity of the considered problems, results indicate that our approach produces a satisfactory number of good predictions in a reasonable time. 相似文献
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A significant number of real‐time control applications include computational activities where the results have to be delivered at precise instants, rather than within a deadline. The performance of such systems significantly degrades if outputs are generated before or after the desired target time. This work presents a general methodology that can be used to design and analyze target‐sensitive applications in which the timing parameters of the computational activities are tightly coupled with the physical characteristics of the system to be controlled. For the sake of clarity, the proposed methodology is illustrated through a sample case study used to show how to derive and verify real‐time constraints from the mission requirements. Software implementation issues necessary to map the computational activities into tasks running on a real‐time kernel are also discussed to identify the kernel mechanisms necessary to enforce timing constraints and analyze the feasibility of the application. A set of experiments are finally presented with the purpose of validating the proposed methodology. Copyright © 2015 John Wiley & Sons, Ltd. 相似文献
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Erick de A. Barboza Carmelo J. A. Bastos-Filho Joaquim F. Martins Filho Marcionilo J. da Silva Leonardo D. Coelho Uiara C. de Moura Juliano R. F. de Oliveira 《Photonic Network Communications》2017,33(2):194-207
In this work we present and analyze three approaches for the adaptive control of the operating point of a cascade of erbium-doped fiber amplifiers (EDFAs), aimed at optical networks performance enhancement. The first approach is called Annealing Search Heuristic with Backpropagation and flexible output (AsHB flex) and uses machine learning concepts to update the amplifier gains through an iterative process. The second one (Exhaustive Method) uses an exhaustive search to evaluate all possible solutions for the problem and obtain the optimum solution. The last one (MaxGain) is a heuristic method that uses previous knowledge about the problem to obtain the solutions. The amplifier characteristics and specifications were obtained experimentally through measurements of gain, noise figure, gain ripple and power consumption on commercially available EDFAs. We performed comparisons among these approaches and others found in the literature, and the results show that the three proposals outperformed the previous ones in terms of noise figure, gain ripple and BER. For example, in a link with four amplifiers the Exhaustive Method achieved a reduction in the cascade noise figure from 10.05 to 5.18 dB, a reduction in the gain ripple from 24.08 to 18.56 dB and a reduction in the BER in almost two orders of magnitude, when compared with the traditional approach, which defines the gain to compensate the loss of the previous link. However, the computation time of Exhaustive Method becomes prohibitive as the number of amplifiers in the link increases. Both MaxGain and AsHBflex obtained similar solutions, close to the optimum operation point in a reasonable time. 相似文献
46.
Electrical,mechanical, and piezoresistive properties of carbon nanotube–polyaniline hybrid filled polydimethylsiloxane composites 下载免费PDF全文
Saul Leyva Egurrola Teresa del Castillo Castro María Mónica Castillo Ortega José Carmelo Encinas Pedro Jesús Herrera Franco José Bonilla Cruz Tania E. Lara Ceniceros 《应用聚合物科学杂志》2017,134(18)
The electrical, mechanical, and piezoresistive properties of ternary composites based on elastomeric polydimethylsiloxane (PDMS), carbon nanotubes (CNTs), and polyaniline (PANI) were studied and compared with those of binary PDMS–CNT composites. The presence of PANI affected the percolating network of the CNTs. At lower PANI concentrations (2.5 and 5%), the conductive network of the CNTs was constructively modified; this led to an enhancement in the conductivity in the sample containing 2% CNTs. A higher PANI content (7.5%) hindered the flow of main charge carriers through the composite. The piezoresistive response of the binary and ternary composites was studied by cyclic experiments under compression loads. In all of the samples, the electrical resistance increased monotonically up to a 10% strain. The reproducibility of the piezoresistive behavior in the binary and ternary composites provided evidence that the fillers could reversibly recover their initial position together with the PDMS chains without a significant displacement with respect to their original positions. The reduction of the piezoresistive sensibility by PANI addition was attributed to the displacement restrictions of the CNTs within the composite under pressure because of the volume exclusion of PANI particles; this maintained the probability of CNT contact and increased the possibility of the formation of new CNT conductive channels. © 2017 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2017 , 134, 44780. 相似文献
47.
Carmelo García Barroso Rafael Cela Torrijos J. A. Pérez-Bustamante 《Zeitschrift für Lebensmitteluntersuchung und -Forschung A》1986,182(5):413-418
Summary The separation and determination of phenolic acids and aldehydes in Fino sherry wine, using high-perfomance liquid chromatography (HPLC), has enabled a study to be carried out of their evolution during the initial process in fino sherry wine production. A continuous extraction method with ethyl ether at pH 2 was chosen, by which the greatest reprodubility in the extraction of these compounds is achieved from must as well as from the wine. For stabilization of the must samples, a mixture of ascorbic acid (0.2%) and DMF (15%) was used, preventing the evolution of colour and the beginning of fermentation. These methods have permitted the study of changes in the content of the phenolic acids and aldehydes during the different stages of fino wine making.
Entwicklung phenolischer Säure und Aldehyde durch verschiedene Erzeugungsprozesse von Fino Xereswein
Zusammenfassung Die Anwendung der HPLC-Technik für die Trennung und quantitative Bestimmung phenolischer Säuren und Aldehyde in Fino Xereswein erlaubte, seine Entwicklung während des Anfangsprozesses der Fino Xereswein-Erzeugung zu beobachten. Ausgewählt wurde eine kontinuierliche Extraktionsmethode mit Ethylether bei pH 2, wodurch höchste Extraktionsreproduzierbarkeit für die in Frage kommenden Verbindungen aus Traubenmost und Wein erreicht werden konnte. Eine Mischung von Ascorbinsäure (0,2%) und Dimethylformamid (15% DMF) wurde zur Stabilisierung der Mostproben angewandt, wodurch die Farbentwicklung und die Gärung unterdrückt wurden. Die angewandte Methode erlaubte die Veränderungen der phenolischen Säuren und der Aldehyde während der verschiedenen Stadien der Weinherstellung zu verfolgen.相似文献
48.
It was the object of the present article to discuss the effect of the addition of a tetrafunctional resin, namely, tetraglycidyl‐4,4′‐diaminodiphenylmethane (TGDDM), and of a novel 40:60 polyethersulfone:polyetherethersulfone (PES:PEES) copolymer on a blend constituted by a difunctional resin, diglycidyl ether of bisphenol S (DGEBS), and an aromatic ammine, 4,4′‐diaminodiphenylsulfone (4,4′DDS). The formulated blends were fully characterized in terms of the morphology and the viscoelastic and mechanical properties. The modification by the tetrafunctional resin was proved to be a useful means to improve the glass transition temperature and, therefore, to widen the range of the working temperature. The addition of the novel copolymer resulted in a marked increase in toughness without negatively affecting the thermal and elastic properties of the blend. TEM analysis, despite the high amount of thermoplastic used, showed a homogeneous morphology that would lead to the conclusion of the existence of a full‐IPN network. Moisture‐uptake experiments were conducted both on the blend and on the resins on their own. It was shown that the combination of the difunctional resin with the tetrafunctional led to a decrease of the percent of the water absorbed. © 2003 Wiley Periodicals, Inc. J Appl Polym Sci 89: 268–273, 2003 相似文献
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