Scientific productivity paradox: The case of China's S&T system

Summary In 1985 China began the reform of its Science & Technology (S&T) sector inherited from the planned economy. To disclose the impact of the drawn-out reform on the efficiency of the whole sector, we measure the scientific productivity of China's S&T institutes. The analysis is based on R&D input and output data at the country aggregate and provincial level. We utilize Polynomial Distributed Lag model to uncover the structure of the lag between R&D input and output. The findings reveal that the growth rate of scientific productivity of China's S&T institutes has been negative since the 1990s.     

Adipose Tissue Dysfunction and Obesity-Related Male Hypogonadism

Obesity is a chronic illness associated with several metabolic derangements and comorbidities (i.e., insulin resistance, leptin resistance, diabetes, etc.) and often leads to impaired testicular function and male subfertility. Several mechanisms may indeed negatively affect the hypothalamic–pituitary–gonadal health, such as higher testosterone conversion to estradiol by aromatase activity in the adipose tissue, increased ROS production, and the release of several endocrine molecules affecting the hypothalamus–pituitary–testis axis by both direct and indirect mechanisms. In addition, androgen deficiency could further accelerate adipose tissue expansion and therefore exacerbate obesity, which in turn enhances hypogonadism, thus inducing a vicious cycle. Based on these considerations, we propose an overview on the relationship of adipose tissue dysfunction and male hypogonadism, highlighting the main biological pathways involved and the current therapeutic options to counteract this condition.     

Modeling Lung Carcinoids with Zebrafish Tumor Xenograft

Lung carcinoids are neuroendocrine tumors that comprise well-differentiated typical (TCs) and atypical carcinoids (ACs). Preclinical models are indispensable for cancer drug screening since current therapies for advanced carcinoids are not curative. We aimed to develop a novel in vivo model of lung carcinoids based on the xenograft of lung TC (NCI-H835, UMC-11, and NCI-H727) and AC (NCI-H720) cell lines and patient-derived cell cultures in Tg(fli1a:EGFP)^y1 zebrafish embryos. We exploited this platform to test the anti-tumor activity of sulfatinib. The tumorigenic potential of TC and AC implanted cells was evaluated by the quantification of tumor-induced angiogenesis and tumor cell migration as early as 24 h post-injection (hpi). The characterization of tumor-induced angiogenesis was performed in vivo and in real time, coupling the tumor xenograft with selective plane illumination microscopy on implanted zebrafish embryos. TC-implanted cells displayed a higher pro-angiogenic potential compared to AC cells, which inversely showed a relevant migratory behavior within 48 hpi. Sulfatinib inhibited tumor-induced angiogenesis, without affecting tumor cell spread in both TC and AC implanted embryos. In conclusion, zebrafish embryos implanted with TC and AC cells faithfully recapitulate the tumor behavior of human lung carcinoids and appear to be a promising platform for drug screening.     

Fix-and-Relax-Coordination for a multi-period location–allocation problem under uncertainty

A multi-period discrete facility location problem is introduced for a risk neutral strategy with uncertainty in the costs and some of the requirements along the planning horizon. A compact 0–1 formulation for the Deterministic Equivalent Model of the problem under two alternative strategies for the location decisions is presented. Furthermore, a new algorithmic matheuristic, Fix-and-Relax-Coordination, is introduced. This solution scheme is based on a specialization of the Branch-and-Fix Coordination methodology, which exploits the Nonanticipativity Constraints and uses the Twin Node Family concept. The results of an extensive computational experience allow to compare the alternative modeling strategies and assess the effectiveness of the proposed approach versus the plain use of a state-of-the-art MIP solver.     

Catalytic Reduction of 4-Nitrobenzoic Acid by cis-[Rh(CO)2(Amine)2](PF6) Complexes Under Water–Gas Shift Reaction Conditions: Kinetics Study

Rhodium(I) complexes of the type, cis-[Rh(CO)₂(amine)₂](PF₆) where (amine = 3-picoline, 2-picoline, pyridine, 2,6-lutidina or 3,5-lutidine) dissolved in 80% aqueous amine solutions catalyzed the selective reduction of 4-nitrobenzoic acid to 4-aminobenzoic acid under CO atmosphere. The importance of these catalytic systems is their high chemo selectivity for the aromatic nitro group of the 4-nitrobenzoic acid with respect to the carboxylic group, allowing the production of the desired aromatic amine in high yields. The 4-aminobenzoic acid production depends on the nature of the coordinated amine. The Rh/3,5-lutidine system, the most active catalyst among tested, displays turnover frequencies for 4-aminobenzoic acid production of about 173 moles per mole Rh per day for [Rh] = 1 × 10^?4 mol, [4-nitrobenzoic acid] = 3.82 × 10^?3mol, 10 mL of 80% aqueous 3,5-lutidine, P(CO) = 0.9 atm at 100 °C. Analyses of kinetic results for the Rh/3,5-lutidine system show a first order dependence on 4-nitrobenzoic acid concentration, a non-linear dependence on CO pressure, a segmented Arrhenius plot and dependence on the nature of the reducing gas agent. These data are discussed in terms of a possible mechanism.     

Vandetanib versus Cabozantinib in Medullary Thyroid Carcinoma: A Focus on Anti-Angiogenic Effects in Zebrafish Model

Medullary thyroid carcinoma (MTC) is a tumor deriving from the thyroid C cells. Vandetanib (VAN) and cabozantinib (CAB) are two tyrosine kinase inhibitors targeting REarranged during Transfection (RET) and other kinase receptors and are approved for the treatment of advanced MTC. We aim to compare the in vitro and in vivo anti-tumor activity of VAN and CAB in MTC. The effects of VAN and CAB on viability, cell cycle, and apoptosis of TT and MZ-CRC-1 cells are evaluated in vitro using an MTT assay, DNA flow cytometry with propidium iodide, and Annexin V-FITC/propidium iodide staining, respectively. In vivo, the anti-angiogenic potential of VAN and CAB is evaluated in Tg(fli1a:EGFP)^y1 transgenic fluorescent zebrafish embryos by analyzing the effects on the physiological development of the sub-intestinal vein plexus and the tumor-induced angiogenesis after TT and MZ-CRC-1 xenotransplantation. VAN and CAB exert comparable effects on TT and MZ-CRC-1 viability inhibition and cell cycle perturbation, and stimulated apoptosis with a prominent effect by VAN in MZ-CRC-1 and CAB in TT cells. Regarding zebrafish, both drugs inhibit angiogenesis in a dose-dependent manner, in particular CAB shows a more potent anti-angiogenic activity than VAN. To conclude, although VAN and CAB show comparable antiproliferative effects in MTC, the anti-angiogenic activity of CAB appears to be more relevant.     

Properties and Stability of Solid Lipid Particle Dispersions Based on Canola Stearin and Poloxamer 188

Solid lipid particles (SLP) are one strategy for encapsulating lipophilic molecules, including for controlled release and enhanced bioavailability applications. SLP based on fully hydrogenated canola stearin (CaSt, 5, 10, 20, and 30 wt%) and the non-ionic surfactant Poloxamer 188 (P188, 0.0, 0.5, 1.0, 2.5, 5.0 and 10.0 wt%) were produced by high pressure melt homogenization using a microfluidizer. Spherical particles in the region of 140 nm were formed, depending on compostion and processing parameters. Surfactant concentration and pressure had a significant influence on particle diameter (P < 0.05), although number of homogenization cycles did not (P > 0.05). A maximum surfactant surface load of approximately 4 mg m⁻² was observed and, at or above 2.5% P188, excess surfactant was present in the continuous phase after production. P188 had the effect of decreasing particle size and facilitating transitions from the α to the β polymorph (P < 0.05) both through surface nucleation and size reduction effects. A stability study of the 10% CaSt SLP with 0.0, 1.0, or 5.0% P188 revealed particle growth for the 0.0 and 1.0% P188 SLP, especially at 20 versus 4 °C, but no changes in the 5.0% P188 SLP, which were exclusively in the β form, at both temperatures for up to 240 days.     

Putting down roots: Afforestation and bank cohesion of Icelandic Rivers

Riparian vegetation is widely recognized as a critical component of functioning fluvial systems. Human pressures on woody vegetation including riparian areas have had lasting effects, especially at high latitude. In Iceland, prior to human settlement, native downy birch woodlands covered approximately 15%–40% of the land area compared to 1%–2% today. Afforestation efforts include planting seedlings, protecting native forest remnants, and acquiring land areas as national forests. The planted and protected nature of vegetation along rivers within forests provides a unique opportunity to evaluate the various taxa within riparian zones and the channel stabilizing characteristics of the vegetation used in afforestation. We investigated bank properties, sediment textures, and root characteristics within riparian zones along four rivers in forests in Iceland. Bank sediment textures are dominantly sandy loam overlying coarser textures. Undercut banks are common because of erosion of the less cohesive subsurface layer. Quantitative root data indicate that the woody taxa have greater root densities, rooting depths, and more complex root structures than forbs or graminoids. The native downy birch has the highest root densities, with <1 mm roots most abundant. Modeling of added bank cohesion indicates that willow provides up to six times and birch up to four times more added cohesion to the coarse sediment textures comprising stream banks compared to no vegetation. We conclude that planting and protecting the native birch and willow helps to reduce bank erosion, especially where long-term grazing exclusion can be maintained.     

Improving Implicit Stochastic Reservoir Optimization Models with Long-Term Mean Inflow Forecast

This technical note introduces a reservoir operation model based on implicit stochastic optimization (ISO) in which the release policy is guided by the forecast of the mean inflow for a given future horizon rather than by the prediction of the current-month inflow, such as in typical ISO models. The model also does not require the forecast of all inflows for the future horizon and shows to be more efficient in finding less vulnerable release policies when compared to several other explicit and implicit stochastic procedures.