Design of a Telescopic Linear Actuator Based on Hollow Shape Memory Springs

Shape memory alloys (SMAs) are smart materials exploited in many applications to build actuators with high power to mass ratio. Typical SMA drawbacks are: wires show poor stroke and excessive length, helical springs have limited mechanical bandwidth and high power consumption. This study is focused on the design of a large-scale linear SMA actuator conceived to maximize the stroke while limiting the overall size and the electric consumption. This result is achieved by adopting for the actuator a telescopic multi-stage architecture and using SMA helical springs with hollow cross section to power the stages. The hollow geometry leads to reduced axial size and mass of the actuator and to enhanced working frequency while the telescopic design confers to the actuator an indexable motion, with a number of different displacements being achieved through simple on-off control strategies. An analytical thermo-electro-mechanical model is developed to optimize the device. Output stroke and force are maximized while total size and power consumption are simultaneously minimized. Finally, the optimized actuator, showing good performance from all these points of view, is designed in detail.     

On estimating the interface normal and curvature in piecewise linear interface calculation-volume of fluid approach for three-dimensional arbitrary meshes

Volume of fluid (VOF) method with its Piecewise Linear Interface Calculation (PLIC) reconstruction algorithm is one of the most popular approaches in numerical simulation of interfacial flows with a wide range of applications in different areas. In an effort to evaluate the similarity of the PLIC-generated planes in comparison with the exact interface, a point-cloud, based on the polygon centers of PLIC planes is extracted, which later is used to form a triangular grid that represents the estimated interface. The main objective of this article is to evaluate the interface geometrical properties based on the extracted triangular grid of the interface. The methods presented in this article, characterized by a higher spatially convergence ratio, are compared with the commonly used methods. The proposed methods are tested for two 3-dimensional general test cases, where an evident improvement is seen in calculation accuracy and spatial convergence of the errors of interface normal vector and curvature.     

The Role of Plasma Extracellular Vesicles in Remote Ischemic Conditioning and Exercise-Induced Ischemic Tolerance

Ischemic conditioning and exercise have been suggested for protecting against brain ischemia-reperfusion injury. However, the endogenous protective mechanisms stimulated by these interventions remain unclear. Here, in a comprehensive translational study, we investigated the protective role of extracellular vesicles (EVs) released after remote ischemic conditioning (RIC), blood flow restricted resistance exercise (BFRRE), or high-load resistance exercise (HLRE). Blood samples were collected from human participants before and at serial time points after intervention. RIC and BFRRE plasma EVs released early after stimulation improved viability of endothelial cells subjected to oxygen-glucose deprivation. Furthermore, post-RIC EVs accumulated in the ischemic area of a stroke mouse model, and a mean decrease in infarct volume was observed for post-RIC EVs, although not reaching statistical significance. Thus, circulating EVs induced by RIC and BFRRE can mediate protection, but the in vivo and translational effects of conditioned EVs require further experimental verification.     

Reduced Levels of ABCA1 Transporter Are Responsible for the Cholesterol Efflux Impairment in β-Amyloid-Induced Reactive Astrocytes: Potential Rescue from Biomimetic HDLs

The cerebral synthesis of cholesterol is mainly handled by astrocytes, which are also responsible for apoproteins’ synthesis and lipoproteins’ assembly required for the cholesterol transport in the brain parenchyma. In Alzheimer disease (AD), these processes are impaired, likely because of the astrogliosis, a process characterized by morphological and functional changes in astrocytes. Several ATP-binding cassette transporters expressed by brain cells are involved in the formation of nascent discoidal lipoproteins, but the effect of beta-amyloid (Aβ) assemblies on this process is not fully understood. In this study, we investigated how of Aβ_1-42-induced astrogliosis affects the metabolism of cholesterol in vitro. We detected an impairment in the cholesterol efflux of reactive astrocytes attributable to reduced levels of ABCA1 transporters that could explain the decreased lipoproteins’ levels detected in AD patients. To approach this issue, we designed biomimetic HDLs and evaluated their performance as cholesterol acceptors. The results demonstrated the ability of apoA-I nanodiscs to cross the blood–brain barrier in vitro and to promote the cholesterol efflux from astrocytes, making them suitable as a potential supportive treatment for AD to compensate the depletion of cerebral HDLs.     

Sodium phthalamates as corrosion inhibitors for carbon steel in aqueous hydrochloric acid solution

Three compounds of N-alkyl-sodium phthalamates were synthesized and tested as corrosion inhibitors for carbon steel in 0.5 M aqueous hydrochloric acid. Tests showed that inhibitor efficiencies were related to aliphatic chain length and dependent on concentration. N-1-n-tetradecyl-sodium phthalamate displayed moderate efficiency against uniform corrosion, 42–86% at 25 °C and 25–60% at 40 °C. Tests indicated that compounds behave as mixed type inhibitors where molecular adsorption on steel followed Langmuir isotherm, whereas thermodynamic suggested that a physisorption process occurred. XPS analysis confirmed film formation on surface, where Fe⁺² complexes and Fe⁺² chelates with phthalamates prevented steel from further corrosion.     

Muscular synergy classification and myoelectric control using high-order cross-cumulants

High-order statistics (HOS) are well suited for describing non-Gaussian random processes. These techniques are increasingly being employed in myoelectric research, on both time and frequency domain techniques. This work presents HOS-based techniques using only HOS time domain features to classify myoelectric signals. The auto-, cross- and full- (joint) third-order cumulants are evaluated as EMG-signal feature vectors to be compared between them. Four surface EMG signals were processed for classify motions from the upper limbs. Synergy among channels is characterized by the features in both auto and cross modes, and their incidences for classifying five or six movements are analyzed. In contrast to the third-order auto-cumulants, it had been verified that the third-order cross-cumulants have the same classification rate by working with five or six movements. A myoelectric control scheme and its experimental application were executed with normal and disabled subjects, reaching a classification rates of 90%, in average. Accuracy in online experiments was similar to the off-line classification rate.

     

CMOS image sensors for sensor networks

We report on two generations of CMOS image sensors with digital output fabricated in a 0.6 μm CMOS process. The imagers embed an ALOHA MAC interface for unfettered self-timed pixel read-out targeted to energy-aware sensor network applications. Collision on the output is monitored using contention detector circuits. The image sensors present very high dynamic range and ultra-low power operation. This characteristics allow the sensor to operate in different lighting conditions and for years on the sensor network node power budget. Eugenio Culurciello (S’97–M’99) received the Ph.D. degree in Electrical and Computer Engineering in 2004 from Johns Hopkins University, Baltimore, MD. In July 2004 he joined the department of Electrical Engineering at Yale University, where he is currently an assistant professor. He founded and instrumented the E-Lab laboratory in 2004. His research interest is in analog and mixed-mode integrated circuits for biomedical applications, sensors and networks, biological sensors, Silicon on Insulator design and bio-inspired systems. Andreas G. Andreou received his Ph.D. in electrical engineering and computer science in 1986 from Johns Hopkins University. Between 1986 and 1989 he held post-doctoral fellow and associate research scientist positions in the Electrical and Computer engineering department while also a member of the professional staff at the Johns Hopkins Applied Physics Laboratory. Andreou became an assistant professor of Electrical and Computer engineering in 1989, associate professor in 1993 and professor in 1996. He is also a professor of Computer Science and of the Whitaker Biomedical Engineering Institute and director of the Institute’s Fabrication and Lithography Facility in Clark Hall. He is the co-founder of the Johns Hopkins University Center for Language and Speech Processing. Between 2001 and 2003 he was the founding director of the ABET accredited undergraduate Computer Engineering program. In 1996 and 1997 he was a visiting professor of the computation and neural systems program at the California Institute of Technology. In 1989 and 1991 he was awarded the R.W. Hart Prize for his work on mixed analog/digital integrated circuits for space applications. He is the recipient of the 1995 and 1997 Myril B. Reed Best Paper Award and the 2000 IEEE Circuits and Systems Society, Darlington Best Paper Award. During the summer of 2001 he was a visiting professor in the department of systems engineering and machine intelligence at Tohoku University. In 2006, Prof. Andreou was elected as an IEEE Fellow and a distinguished lecturer of the IEEE EDS society. Andreou’s research interests include sensors, micropower electronics, heterogeneous microsystems, and information processing in biological systems. He is a co-editor of the IEEE Press book: Low-Voltage/Low-Power Integrated Circuits and Systems, 1998 (translated in Japanese) and the Kluwer Academic Publishers book: Adaptive Resonance Theory Microchips, 1998. He is an associate editor of IEEE Transactions on Circuits and Systems I.     

Squeezing spectra from s -ordered quasiprobability distributions: application to dispersive optical bistability

It is well known that the squeezing spectrum of the field exiting a nonlinear cavity can be directly obtained from the fluctuation spectrum of normally ordered products of creation and annihilation operators of the cavity mode. In this article we show that the output field squeezing spectrum can be derived also by combining the fluctuation spectra of any pair of s -ordered products of creation and annihilation operators. The interesting result is that the spectrum obtained in this way from the linearized Langevin equations is exact, and this occurs in spite of the fact that no s -ordered quasiprobability distribution verifies a true Fokker–Planck equation; that is, the Langevin equations used for deriving the squeezing spectrum are not exact. The (linearized) intracavity squeezing obtained from any s -ordered distribution is also exact. These results are exemplified in the problem of dispersive optical bistability.     

Evolution of railway network flexibility: The Spanish broad gauge case

The length of the Spanish broad gauge network has decreased in the 1956–2006 period. When looking at different railway maps through this period, it seems that the network is offering fewer and fewer alternatives when a line is cut, that is, the network is becoming less and less flexible. The goal of this article is to prove that the flexibility of the Spanish broad gauge network has decreased substantially in the 1956–2006 period. We have considered the network as a graph (ignoring traditional railway quality indicators such as commercial speed, number of tracks, electrifications, signaling, …) and we have chosen two simple indicators as accurate in this sense: the number of cycles (cycles provide an alternative to reach a station if there is a problem in one line) and the number of stations of intermediate degree. To achieve this, we have developed a piece of software that is an ad hoc extension of Maple’s networks package.