Molecular and geographic patterns of tuberculosis transmission after 15 years of directly observed therapy

Stevioside is a sweet-tasting glycoside, composed of stevia, a diterpenic carboxylic alcohol with three glucose molecules, mainly used as a substitute for non-alcoholic sweetener. It has previously been shown to reduce blood pressure in studies in animals and human. The effect of intravenous stevioside on the blood pressure was studied in spontaneously hypertensive rats (SHR). The hypotensive effect on both systolic and diastolic blood pressure was dose-dependent for intravenous doses of 50, 100 and 200 mg/kg in conscious SHR. The maximum reductions in systolic and diastolic blood pressure were 31.4 +/- 4.2% and 40.8 +/- 5.6% (mean +/- SEM) respectively and the hypotensive effect lasted for more than 60 min with a dose of 200 mg/kg. Serum dopamine, norepinephrine and epinephrine levels were not changed significantly 60 min after intravenous injection of stevioside 100 mg/kg in anesthetized SHR. The present data show that stevioside given intravenously to conscious SHR was effective in blood pressure reduction and there was no change in serum catecholamines in anaesthetized animals with this natural compound.     

Transcytosis of alpha1-acidic glycoprotein in the continuous microvascular endothelium

By using perfusions and bolus administration, coupled with postembedding immunocytochemical procedures, we have identified the structures involved in the transport of derivatized orosomucoid (alpha1-acidic glycoprotein) across the continuous microvascular endothelium of the murine myocardium. Our findings indicate that: (i) monomeric orosomucoid binds to the luminal surface of the endothelium; (ii) it is restricted to caveolae during its transport across the endothelium; (iii) it is detected in the perivascular spaces at early time points (by 1 min) and in larger quantities at later time points (>5 min) from the beginning of its perfusion or its intravascular administration; (iv) no orosomucoid molecules are found in the intercellular junctions or at the abluminal exits of interendothelial spaces; and (v) the vesicular transport of orosomucoid is strongly inhibited by N-ethylmaleimide (>80%). Because, by size and shape, the orosomucoid qualifies as a preferential probe for the postulated small pore system, our results are discussed in relation to the pore theory of capillary permeability.     

微量Si在W—7Ni—3Fe重合金中的行为

研究了掺到原料Ｗ粉中微量Ｓｉ（４００ｐｐｍ）在Ｗ－７Ｎｉ－３Ｆｅ重合金中的分布及在液相烧结过程中的行为。结果表明，Ｓｉ主要以固溶形式分布在Ｗ晶粒中。Ｘ射线光电子能谱（ＸＰＳ）分析发现，在掺杂Ｓｉ的Ｗ－Ｗ及Ｗ－基体相界面富集ＳｉＯ２和Ｎａ２ＳｉＯ３在未掺杂试样的断口表面发现了较弱的ＷＯ２的ＸＰＳ谱，而在掺杂合金中未发现ＷＯ２。     

Endotoxin-induced platelet aggregation in heparinised equine whole blood in vitro

Endotoxaemia is a leading cause of death among horses. Thrombocytopenia is a common finding in clinical and experimentally-induced cases of endotoxaemia and can lead to coagulopathies, including disseminated intravascular coagulopathy which is usually fatal. In this study it was shown that endotoxin (3 ng ml-1 to 25 micrograms ml-1) can aggregate equine platelets in heparinised whole blood in vitro. The endotoxin-induced aggregation (EIA) was shown to be dependent on the presence of leucocytes in the blood and did not occur when detoxified endotoxin was used, suggesting that lipid A was necessary for the response. Aspirin (1 mmol litre-1) had no effect on EIA whereas apyrase (40 micrograms ml-1) completely abolished it and CV3988 (3 to 30 mumol litre-1) (a competitive antagonist of platelet-activating factor) inhibited the response in a concentration-dependent manner. It is concluded that endotoxin activates equine platelets at low concentrations through an indirect mechanism that involves calcium, leucocytes, adenine nucleotides and platelet-activating factor.     

游艇概念设计方法与技术研究

针对游艇的概念设计方法与技术展开研究,从创意设计思维层面入手,建立了游艇设计概念引入、意象及内涵深化的设计创意库,包括海洋生物库、东方文化符号库、其它类产品创意库等三大类;分析了游艇概念设计从抽象到具体的过程,提出了游艇创意概念设计的底影套模法;探讨了游艇设计的参数化、模块化实现技术。     

双余度DSP数据采集装置在某型控制器中的应用

针对某型控制器设计的双余度DSP数据采集装置,采用以双端口RAM方式进行数据交换。结果表明,此数据采集装置既能快速完成模拟数据的采样,又能快速地在DSP间进行高速数据交换,同时,还能够满足基于DSP数据采集装置的高精度与小型化要求。     

江阴市"十四五"水利高质量发展规划的思考

总结江阴市"十三五"水利发展规划在水安全、水资源、水生态、农村水利、水管理服务及水利发展保障等方面的完成情况.分析江阴市水利发展存在的主要短板、问题.围绕建设高质量的水安全保障体系、水资源配置体系、水生态治理体系、水利管理体系、水利服务体系,系统提出江阴市"十四五"水利高质量发展规划思路.     

Scalable influence maximization for independent cascade model in large-scale social networks

Influence maximization, defined by Kempe et al. (SIGKDD 2003), is the problem of finding a small set of seed nodes in a social network that maximizes the spread of influence under certain influence cascade models. The scalability of influence maximization is a key factor for enabling prevalent viral marketing in large-scale online social networks. Prior solutions, such as the greedy algorithm of Kempe et al. (SIGKDD 2003) and its improvements are slow and not scalable, while other heuristic algorithms do not provide consistently good performance on influence spreads. In this article, we design a new heuristic algorithm that is easily scalable to millions of nodes and edges in our experiments. Our algorithm has a simple tunable parameter for users to control the balance between the running time and the influence spread of the algorithm. Our results from extensive simulations on several real-world and synthetic networks demonstrate that our algorithm is currently the best scalable solution to the influence maximization problem: (a) our algorithm scales beyond million-sized graphs where the greedy algorithm becomes infeasible, and (b) in all size ranges, our algorithm performs consistently well in influence spread—it is always among the best algorithms, and in most cases it significantly outperforms all other scalable heuristics to as much as 100–260% increase in influence spread.     

冠心病智能诊断算法仿真研究

研究冠心病诊断问题,冠心病影响指标多,指标体系中存在大量的重复信息,传统方法无法消除重复信息,冠心病诊断准确率低,误诊率高.为了提高冠心病诊断准确率,提出一种智能的冠心病诊断算法.首先科学、准确地选择冠心病指标体系,然后采用主成分分析对指标体系进行筛选,消除重复信息,最后采用支持向量机对冠心病建立分类器,实现冠心病智能诊断.仿真结果表明,相对于其它传统冠心病诊断方法,智能诊断算法有效提高了冠心病诊断准确率,克服了传统诊断缺限,为冠心病临床诊断提供了依据.