Experiments on sediment trap efficiency in reservoirs

Sediment trap efficiency plays a key role in the effective operational life of reservoirs. This paper presents the results of five laboratory experiments on trap efficiency. An over‐spilling condition and four gaps located at the downstream end of a reservoir were analysed in this study. The experimental design assumed a river carrying two phases of sediment flowing into a one‐dimensional reservoir. The coarse sediment (sand) was deposited and formed a defined prograding delta. The fine sediment (mud) formed a dilute suspension of wash load in the river. As the river entered the reservoir, the muddy water plunged on the foreset, forming a turbidity current. The turbidity current deposits, in turn, formed a bottomset. Black coal slag and white glass beads were used to simulate sand and mud. Their specific densities were 2.6 and 2.5 for black coal and beads, respectively. The water surface elevation in the reservoir was approximately similar in all experiments. Neither the water nor sediment discharge conditions were changed during the experimental runs. Suspended sediment was sampled through seven siphons; six of these being components of a rake in which they were vertically stacked. The last siphon was positioned on the rake outlet. Sediment samples were taken three times, at approximately evenly spaced intervals in the experiments. Suspended sediment concentration and grain size distribution were calculated for each siphon. The bed sediment deposit was sampled after each experiment. Sediment trap efficiency in the reservoir was calculated. Experimental results show the maximum venting capacity (minimum trap efficiency) occurs under over‐spilling conditions.     

A new class of pseudopeptide antagonists of the kinin B1 receptor containing alkyl spacers

Four previously reported kinin receptor peptide antagonists, including the B1 receptor-selective peptides desArg10-HOE 140 (H-D-Arg-Arg-Pro-Hyp-Gly-Thi-Ser-D-Tic-Oic-OH) and B-9858 (H-Lys-Lys-Arg-Pro-Hyp-Gly-Igl-Ser-D-Igl-Oic-OH), have been modified by replacement of the central tetrapeptide Pro-Hyp-Gly-Xaa with linear alkyl spacers of variable length. The analogue of desArg10-HOE 140 containing the 11-aminoundecanoic acid as spacer, MEN 11575 [H-D-Arg-Arg-NH-(CH2)10-CO-Ser-D-Tic-Oic-OH], was found to be slightly more potent than the unmodified peptide (pA2 = 7.1) as a kinin B1 receptor antagonist in the rat ileum longitudinal smooth muscle assay. Moreover, MEN 11575 is devoid of residual agonist activity at the kinin B1 receptor (rat ileum) and antagonist activity at the kinin B2 receptor (guinea pig ileum longitudinal smooth muscle). Both these activities are displayed by the parent peptide desArg10-HOE 140. Therefore, despite its greatly simplified chemical structure, MEN 11575 shows an improved pharmacological profile in terms of both potency and selectivity, and it represents a good template for the development of new peptidomimetic kinin B1 receptor antagonists. We also report an attempt to investigate the conformational role of the flexible, linear spacer of MEN 11575 and to design more constrained analogues, possibly locked in the bioactive conformation, using semirigid spacers based on Calpha-tetrasubstituted alpha-amino acids of the family of 1-aminocycloalkane-1-carboxylic acids (Acnc).     

Temporal Sampling of Enzymes from Live Cells by Localized Electroporation and Quantification of Activity by SAMDI Mass Spectrometry

Measuring changes in enzymatic activity over time from small numbers of cells remains a significant technical challenge. In this work, a method for sampling the cytoplasm of cells is introduced to extract enzymes and measure their activity at multiple time points. A microfluidic device, termed the live cell analysis device (LCAD), is designed, where cells are cultured in microwell arrays fabricated on polymer membranes containing nanochannels. Localized electroporation of the cells opens transient pores in the cell membrane at the interface with the nanochannels, enabling extraction of enzymes into nanoliter‐volume chambers. In the extraction chambers, the enzymes modify immobilized substrates, and their activity is quantified by self‐assembled monolayers for matrix‐assisted laser desorption/ionization (SAMDI) mass spectrometry. By employing the LCAD‐SAMDI platform, protein delivery into cells is demonstrated. Next, it is shown that enzymes can be extracted, and their activity measured without a loss in viability. Lastly, cells are sampled at multiple time points to study changes in phosphatase activity in response to oxidation by hydrogen peroxide. With this unique sampling device and label‐free assay format, the LCAD with SAMDI enables a powerful new method for monitoring the dynamics of cellular activity from small populations of cells.     

Computing the distance between a nonlinear model and its linear approximation: an approach

In this paper we consider the following problem: viewing both a nonlinear system model and its linearization as mappings from input-to-state, we define the error between the state of the original nonlinear system and that of the linearization and find the region of the state space where this error is norm-bounded, in the integral-square (or -norm) sense. Using the Hamilton–Jacobi inequality we define the distance between these two systems as the upper bound of this error.     

Optimization of gear ratio and power distribution for a multimotor powertrain of an electric vehicle

The architecture and design of the propulsion system of electric vehicles are highly important for the reduction of energy losses. This work presents a powertrain composed of four electric motors in which each motor is connected with a different gear ratio to the differential of the rear axle. A strategy to reduce energy losses is proposed, in which two phases are applied. Phase 1 uses a divide-and-conquer approach to increase the overall output efficiency by obtaining the optimal torque distribution for the electric motors. Phase 2 applies a genetic algorithm to find the optimal value of the gear ratios, in which each individual of each generation applies Phase 1. The results show an optimized efficiency map for the output torque and speed of the powertrain. The increase in efficiency and the reduction of energy losses are validated by the use of numerical experiments in various driving cycles.     

The Top-Down Strategy for Building EuroWordNet: Vocabulary Coverage, Base Concepts and Top Ontology

This paper describes two fundamental aspects in the process of building of the EuroWordNet database. In EuroWordNet we have chosen for a flexible design in which local wordnets are built relatively independently as language-specific structures, which are linked to an Inter-Lingual-Index (ILI). To ensure compatibility between the wordnets, a core set of common concepts has been defined that has to be covered by every language. Furthermore, these concepts have been classified via the ILI in terms of a Top Ontology of 63 fundamental semantic distinctions used in various semantic theories and paradigms. This paper first discusses the process leading to the definition of the set of Base Concepts, and the structure and the rationale of the Top Ontology.     

Localization in time and space for wireless sensor networks: An efficient and lightweight algorithm

In many applications that use Wireless Sensor Networks (WSNs), detected events need to be localized in both time and space. As a result, sensor nodes need to have precisely synchronized clocks as well as to be localized in a common spatial reference system. While synchronization and localization algorithms have been proposed to solve these problems independently, in this work we propose to combine both synchronization and localization into a single problem that we refer to as the time–space localization problem. We then propose a novel and efficient time–space localization algorithm for wireless sensor networks which we refer to as the Lightness algorithm. Our proposed algorithm not only takes advantage of the additional hardware resources required by the positioning mechanism in order to improve the performance and scalability of synchronization, but also benefits from the additional communication needed by the synchronization mechanism in order to decrease positioning errors. We also present an extensive set of experiments to evaluate the performance of our algorithm. Our results indicate clearly that our proposed scheme is scalable while keeping a low synchronization error and a low communication overhead. Our results also indicate that the additional packets needed to compute clocks’ drift have the ability to decrease the positioning errors to almost one third of the initial positioning.