Handle height and expectation of cart movement affect the control of trunk motion at movement onset in cart pushing

As unexpected sudden unloading of the trunk may cause low-back injury, the objective of the present study was to investigate whether handle height and the expectation of cart movement in pushing affect trunk control at movement onset. Eleven healthy male participants pushed a 200-kg cart with handles at shoulder and hip heights. The cart would suddenly move when externally released (externally triggered condition) or when static friction was overcome (self-initiated condition). Before self-initiated cart movement, trunk stiffness and muscle activity were significantly higher than before an externally triggered onset at comparable pushing force. Lower muscle activity and trunk stiffness at shoulder height compared with the hip height before the onset resulted in higher trunk inclination after the onset. In conclusion, higher preparatory activation of trunk muscles serves to increase trunk stiffness in anticipation of cart movement and may reduce the impact of the perturbation associated with the onset of cart movement. STATEMENT OF RELEVANCE: Sudden cart movement in pushing causes an unexpected unloading perturbation to the trunk. This perturbation was shown to cause uncontrolled trunk movement, which may explain how pushing tasks can be associated with low-back injury. Effects of handle height and awareness of the subjects of the possible cart movement suggest directions for prevention.     

European new build and fuel cycles in the 21st century

Nuclear energy is back on the agenda worldwide. In order to prepare for the next decades and to set priorities in nuclear R&D and investment, it is important to assess the future nuclear fuel cycle. This allows to identify the triggers which influence the market penetration of future nuclear reactor technologies.To this purpose, fuel cycle scenarios for a future nuclear reactor park in Europe have been analysed applying an integrated dynamic process modelling technique. The assessment was undertaken using the DANESS code (Dynamic Analysis of Nuclear Energy System Strategies, developed by Argonne National Laboratory (US)). This code allows to provide a complete picture of mass flows and economics of the various nuclear fuel cycle scenarios.The present assessment recognizes the integrated nuclear fuel cycle and concentrates on the evolution under consideration of increased uranium prices, increased costs for geological disposal, lifetime extension of the current reactor park, and various nuclear energy demand scenarios. The analyses show that the future European nuclear park will consist of a mix of Gen-III and Gen-IV reactors. The relative shares of the reactor types in the total mix depend on the applied boundary conditions such as the future nuclear energy demand, the reactor characteristics, and the assumed economical factors. Furthermore, the analyses highlight the triggers influencing the choices between different nuclear energy deployment scenarios, and enable an evaluation of future types and amounts of nuclear waste. In addition, a dynamic assessment is made with regard to employment of manpower for a future nuclear fleet in the different scenarios. Finally an estimate is provided of the radiological impact on the regional population due to the release of potentially hazardous radionuclides during the different steps in the nuclear fuel cycle.     

Galactose in the Post-Weaning Diet Programs Improved Circulating Adiponectin Concentrations and Skeletal Muscle Insulin Signaling

Short-term post-weaning nutrition can result in long-lasting effects in later life. Partial replacement of glucose by galactose in the post-weaning diet showed direct effects on liver inflammation. Here, we examined this program on body weight, body composition, and insulin sensitivity at the adult age. Three-week-old female C57BL/6JRccHsd mice were fed a diet with glucose plus galactose (GAL; 16 energy% (en%) each) or a control diet with glucose (GLU; 32 en%) for three weeks, and afterward, both groups were given the same high-fat diet (HFD). After five weeks on a HFD, an oral glucose tolerance test was performed. After nine weeks on a HFD, energy metabolism was assessed by indirect calorimetry, and fasted mice were sacrificed fifteen minutes after a glucose bolus, followed by serum and tissue analyses. Body weight and body composition were not different between the post-weaning dietary groups, during the post-weaning period, or the HFD period. Glucose tolerance and energy metabolism in adulthood were not affected by the post-weaning diet. Serum adiponectin concentrations were significantly higher (p = 0.02) in GAL mice while insulin, leptin, and insulin-like growth factor 1 concentrations were not affected. Expression of Adipoq mRNA was significantly higher in gonadal white adipose tissue (gWAT; p = 0.03), while its receptors in the liver and skeletal muscles remained unaffected. Irs2 expression was significantly lower in skeletal muscles (p = 0.01), but not in gWAT or Irs1 expression (in both tissues). Gene expressions of inflammatory markers in gWAT and the liver were also not affected. Conclusively, galactose in the post-weaning diet significantly improved circulating adiponectin concentrations and reduced skeletal muscle Irs2 expression in adulthood without alterations in fat mass, glucose tolerance, and inflammation.     

Validation of multiparametric MRI by histopathology after nephrectomy: a case study

Magnetic Resonance Materials in Physics, Biology and Medicine - Renal multiparametric MRI (mpMRI) is a promising tool to monitor renal allograft health to enable timely treatment of chronic...     

Sulfide-induced nitrate reduction in the sludge of an anaerobic digester of a zero-discharge recirculating mariculture system

The anaerobic digester is a vital component in a zero-discharge mariculture system as therein most of the organic matter is mineralized and nitrogen-containing compounds are converted to gaseous N₂. Although denitrification is a major respiratory process in this nitrate-rich treatment stage, also sulfate respiration takes place and may cause undesirable high sulfide concentrations in the effluent water. To examine the effect of sulfide on nitrate reduction, in situ depth profiles of inorganic nitrogen and sulfur compounds were determined. Additionally, nitrate reduction was examined as a function of ambient sulfide concentrations in sludge collected from different locations in the anaerobic reactor. Depth profiles showed high concentrations of nitrate and low concentrations of sulfide and ammonia in the aqueous layer of the reactor. A sharp decrease of nitrate and an increase in sulfide and ammonia concentrations was measured at the water-sludge interface. Nitrate reduction was highest in this interface zone with rates of up to 8.05 ± 0.57 μmol NO₃⁻ h⁻¹ g_(sludge)⁻¹. Addition of sulfide increased the nitrate reduction rate at all sludge depths, pointing to the important role of autotrophic denitrification in the anaerobic reactor. Dissimilatory nitrate reduction to ammonia (DNRA) was found to be low in all sludge layers but was enhanced when sludge was incubated at high sulfide concentrations. Although nitrate reduction rates increased as a result of sulfide addition to sludge samples, no differences in nitrate reduction rates were observed between the samples incubated with different initial sulfide concentrations. This as opposed to sulfide oxidation rates, which followed Michaelis-Menten enzymatic kinetics. Partial oxidation of sulfide to elemental sulfur instead of a complete oxidation to sulfate, could explain the observed patterns of nitrate reduction and sulfide oxidation in sludge incubated with different initial sulfide concentrations.     

Residence time distribution in a single‐phase rotor–stator spinning disk reactor

A reactor model for the single‐phase rotor–stator spinning disk reactor based on residence time distribution measurements is described. For the experimental validation of the model, the axial clearance between the rotor and both stators is varied from 1.0 × 10^?3 to 3.0 × 10^?3 m, the rotational disk speed is varied from 50 to 2000 RPM, and the volumetric flow rate is varied from 7.5 × 10^?6 to 22.5 × 10^?6 m³ s^?1. Tracer injection experiments show that the residence time distribution can be described by a plug flow model in combination with 2–3 ideally stirred tanks‐in‐series. The resulting reactor model is explained with the effect of turbulence, the formation of Von Kármán and Bödewadt boundary layers, and the effect of the volumetric flow rate. © 2013 American Institute of Chemical Engineers AIChE J, 59: 2686–2693, 2013     

Separation and recovery of the constituents from lignocellulosic biomass by using ionic liquids and acetic acid as co-solvents for mild hydrolysis

Previously, ionic liquids were found to partially dissolve lignocellulosic biomass. Here, it is reported that the biomass itself does not dissolve directly, but that it is hydrolyzed first before the constituents (cellulose, hemicellulose and lignin) dissolve into the ionic liquid. By addition of an acidic catalyst, this hydrolysis step can take place at milder conditions. Acetic acid is chosen as a suitable acidic catalyst, because it is already present in lignocellulosic biomass in the form of acetyl groups on the hemicellulose. Here, it is shown that acetic acid also works as co-solvent, increasing the solubility of the constituents of lignocellulosic biomass in the ionic liquid. The milder conditions for hydrolysis result in a higher degree of utilization of the lignocellulosic biomass, whereby all constituents can be fully recovered and further processed and the ionic liquid can be reused.     

Office workers' computer use patterns are associated with workplace stressors

This field study examined associations between workplace stressors and office workers' computer use patterns. We collected keyboard and mouse activities of 93 office workers (68F, 25M) for approximately two work weeks. Linear regression analyses examined the associations between self-reported effort, reward, overcommitment, and perceived stress and software-recorded computer use duration, number of short and long computer breaks, and pace of input device usage. Daily duration of computer use was, on average, 30 min longer for workers with high compared to low levels of overcommitment and perceived stress. The number of short computer breaks (30 s–5 min long) was approximately 20% lower for those with high compared to low effort and for those with low compared to high reward. These outcomes support the hypothesis that office workers' computer use patterns vary across individuals with different levels of workplace stressors.     

Intensification of convective heat transfer in a stator–rotor–stator spinning disc reactor

A stator–rotor–stator spinning disc reactor is presented, which aims at intensification of convective heat‐transfer rates for chemical conversion processes. Single phase fluid‐rotor heat‐transfer coefficients h_r are presented for rotor angular velocities rad s^?1 and volumetric throughflow rates m³s^?1. The values of h_r are independent of and increase from 0.95 kWm^?2K^?1 at ω = 0 rad s^?1 to 34 kWm^?2K^?1 at ω = 157 rad s^?1. This is a factor 2–3 higher than values achievable in passively enhanced reactor‐heat exchangers, due to the 1–2 orders of magnitude larger specific energy input achievable in the stator–rotor–stator spinning disc reactor. Moreover, as h_r is independent of , the heat‐transfer rates are independent of residence time. Together with the high mass‐transfer rates reported for rotor–stator spinning disc reactors, this makes the stator–rotor–stator spinning disc reactor a promising tool to intensify heat‐transfer rates for highly exothermal chemical reactions. © 2015 American Institute of Chemical Engineers AIChE J, 61: 2307–2318, 2015     

Designing flow and temperature uniformities in parallel microchannels reactor

A design methodology is proposed to maintain gas and liquid flow nonuniformities below an acceptable limit in a parallel micro/millichannels reactor by determining the maximum allowed temperature deviation in each part of the reactor. The effect of temperature deviation on flow distribution was quantified using a hydraulic resistive network model. The effect of flow rate on temperature deviation was demonstrated using a one‐dimensional energy balance model. Experiments were conducted using the barrier‐based micro/millichannels reactor (BMMR). Flow distribution in the BMMR is based on placing hydraulic resistances (barrier channels) in the gas and liquid manifolds to regulate the flows. Temperature deviation in the barrier channels affects flow nonuniformity by 10 times more than in the reaction channels. Above a certain critical liquid residence time, flow rate has no significant effect on the temperature deviation which depends on the liquid used, reactor material of construction, and its geometrical dimensions. © 2014 American Institute of Chemical Engineers AIChE J, 60: 1941–1952, 2014