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61.
Cardiovascular (CV) disease is the single most significant cause of morbidity and mortality worldwide. The emerging global impact of CV disease means that the goals of early diagnosis and a wider range of treatment options are now increasingly pertinent. As such, there is a greater need to understand the molecular mechanisms involved and potential targets for intervention. Mitochondrial function is important for physiological maintenance of the cell, and when this function is altered, the cell can begin to suffer. Given the broad range and significant impacts of the cellular processes regulated by the mitochondria, it becomes important to understand the roles of the proteins associated with this organelle. Proteomic investigations of the mitochondria are hampered by the intrinsic properties of the organelle, including hydrophobic mitochondrial membranes; high proportion of basic proteins (pI greater than 8.0); and the relative dynamic range issues of the mitochondria. For these reasons, many proteomic studies investigate the mitochondria as a discrete subproteome. Once this has been achieved, the alterations that result in functional changes with CV disease can be observed. Those alterations that lead to changes in mitochondrial function, signaling and morphology, which have significant implications for the cardiomyocyte in the development of CV disease, are discussed. 相似文献
62.
Tanya Goette Caroline Collier Jennifer Daniels White 《Universal Access in the Information Society》2006,5(1):41-50
This paper focuses on Web accessibility. Relevant legislation and judicial decisions are reviewed, and prior empirical research is presented. This study presents the results from the Web accessibility analysis of the home pages of the 50 states and the District of Columbia. It found that twenty-nine percent of the home pages do not meet the requirements for Conformance Level A Web accessibility. Only one state meets Conformance Level AA standards, which are the minimum standards recommended for Web accessibility, and no state meets Conformance Level AAA standards. This paper also discusses how to address common accessibility problems.
相似文献
Tanya GoetteEmail: Phone: +1-478-4455721 |
63.
Gertrud K. Nürnberg Lewis A. Molot Eavan O'Connor Hamdi Jarjanazi Jennifer Winter Joelle Young 《Journal of Great Lakes research》2013
Hypoxia and cyanobacterial blooms were extensive in Lake Simcoe during the 1980s and are still a problem to a lesser degree despite extensive nutrient load reduction from the catchment basin. The continuing signs of productivity indicate a potential internal phosphorus (P) source. Internal P load, as a redox-dependent release from bottom sediments, is hard to determine in a large, relatively shallow and partially unstratified lake such as Lake Simcoe. Of the lake's three major basins, only Kempenfelt Bay stratifies long enough to develop hypoxia in the stagnant summer hypolimnion. The following indications of sediment P release are available from historic data: 1) hypolimnetic hypoxia still occurs in Kempenfelt Bay although the hypoxic factor (number of days that an area equal to the bay's surface area is overlain by water of ≤ 2 mg/L dissolved oxygen, DO) has decreased substantially and significantly from 15.8 d/yr (1980–1994) to 4.0 d/yr (1995–2011); 2) hypoxic factors for other lake sections and at different DO levels also indicate widespread hypoxia; 3) concentrations of redox dependent metals, Fe and Mn, increase with depth; and 4) euphotic zone P and chlorophyll concentrations increase and water clarity decreases during fall turnover. Cyanobacterial blooms appear to occur in response to internal load as supported by occasional cyanobacteria counts. These indicators provide evidence that internal loading is likely occurring and affecting the water quality in Lake Simcoe. We expect that further monitoring, specific for internal load, will corroborate these results. 相似文献
64.
Danielle M. Law Jennifer D. ShapkaShelley Hymel Brent F. OlsonTerry Waterhouse 《Computers in human behavior》2012,28(1):226-232
Electronic aggression, or cyberbullying, is a relatively new phenomenon. As such, consistency in how the construct is defined and operationalized has not yet been achieved, inhibiting a thorough understanding of the construct and how it relates to developmental outcomes. In a series of two studies, exploratory and confirmatory factor analyses (EFAs and CFAs respectively) were used to examine whether electronic aggression can be measured using items similar to that used for measuring traditional bullying, and whether adolescents respond to questions about electronic aggression in the same way they do for traditional bullying. For Study I (n = 17 551; 49% female), adolescents in grades 8-12 were asked to what extent they had experience with physical, verbal, social, and cyberbullying as a bully and victim. EFA and CFA results revealed that adolescents distinguished between the roles they play (bully, victim) in a bullying situation but not forms of bullying (physical, verbal, social, cyber). To examine this further, Study II (n = 733; 62% female), asked adolescents between the ages of 11 and 18 to respond to questions about their experience sending (bully), receiving (victim), and/or seeing (witness) specific online aggressive acts. EFA and CFA results revealed that adolescents did not differentiate between bullies, victims, and witnesses; rather, they made distinctions among the methods used for the aggressive act (i.e. sending mean messages or posting embarrassing pictures). In general, it appears that adolescents differentiated themselves as individuals who participated in specific mode of online aggression, rather than as individuals who played a particular role in online aggression. This distinction is discussed in terms of policy and educational implications. 相似文献
65.
Danielle M. Law Jennifer D. Shapka José F. Domene Monique H. Gagné 《Computers in human behavior》2012
Cyberbullying, or online aggression, is an issue of increasing concern, however little research has been conducted on the motivations underlying this form of aggression. Using a mixed-method approach, by means of survey and interview data, we explored whether online aggressive acts were motivated by proactive (intentionally aggressing to obtain a resource or a goal), and/or reactive (aggression that occurs in reaction to provocation) reasons. Participants for the survey portion of the study included 733 adolescents between the ages of 10 and 18, while a subset of 15 adolescents participated in semi-structured interviews. Factor analysis revealed that, in contrast to traditional forms of bullying, adolescents do not identify themselves according to the role they played in an internet aggressive situation (i.e. bully, victim, witness), but according to the method of aggression they used (i.e. sending mean messages, posting embarrassing photos, and developing hostile websites). More interestingly, regression analyses demonstrated that motivations for aggressing online also varied according to method of aggression rather than role. For example, adolescents who chose to aggress by posting mean messages or posting embarrassing photos were more likely to do so for reactive reasons, while adolescents who spent time creating hostile websites did so for proactive reasons. 相似文献
66.
Effects of Sexually Objectifying Media on Self-Objectification and Body Surveillance in Undergraduates: Results of a 2-Year Panel Study 总被引:2,自引:0,他引:2
Jennifer Stevens Aubrey 《The Journal of communication》2006,56(2):366-386
This study used objectification theory (B. L. Fredrickson & T.-A. Roberts, 1997) to predict that the media's insidious practice of objectifying bodies socializes individuals to take an outsider's perspective on the physical self (i.e., self-objectify) and to habitually monitor their appearance (i.e., engage in body surveillance). To test these hypotheses, a 2-year panel study using an undergraduate sample was conducted. Cross-lagged path models showed that exposure to sexually objectifying television measured during Year 1 increased trait self-objectification (trait SO) during Year 2 for both women and men. At the same time, trait SO during Year 1 decreased exposure to sexually objectifying television during Year 2, suggesting that both male and female participants selectively avoided sexually objectifying television based on antecedent trait SO. Moreover, exposure to sexually objectifying television and magazines increased body surveillance for men only. The discussion focuses on the process by which the media create body-focused perceptions. 相似文献
67.
Stern Emily R.; Horvitz Jon C.; C?té Lucien J.; Mangels Jennifer A. 《Canadian Metallurgical Quarterly》2005,19(1):54
The authors explored the effect of Parkinson's disease (PD) on the generation and maintenance of response readiness in a simple reaction time task. They compared performance of idiopathic PD patients without dementia, age-matched controls, and younger controls over short (1-, 3-, and 6-s) and long (12- and 18-s) foreperiod intervals. After each trial, the authors probed memory for visual information that also had to be maintained during the trial interval. Patients and controls did not differ overall in their ability to maintain readiness over long delays. However, within the PD group only, errors in maintaining visual information were correlated with difficulty in maintaining readiness, suggesting that systems impaired in PD may facilitate the maintenance of processing in both motor and cognitive domains. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
68.
Silk Jennifer S.; Sessa Frances M.; Sheffield Morris Amanda; Steinberg Laurence; Avenevoli Shelli 《Canadian Metallurgical Quarterly》2004,18(1):135
This study explored the moderating effects of children's neighborhoods on the link between hostile parenting and externalizing behavior. Participants were 1st- or 2nd-grade children in an urban northeastern community. Children were administered the Parenting and Neighborhood scales of the Child Puppet Interview, and mothers completed questionnaires on neighborhood quality and parenting practices. Census tract measures of neighborhood quality and teachers' reports of children's externalizing behavior also were obtained. Results indicated that children's and mothers' perceptions of neighborhood involvement-cohesion buffered the link between hostile parenting and externalizing problems. Children's externalizing behavior was unrelated to census tract variables. Findings highlight the protective effect of neighborhood social cohesion and the utility of including young children's perspectives in research on neighborhoods and families. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
69.
Biofiltration, a process in which contaminated air is passed through a biologically active bed, can be used to remove volatile organic pollutants from air streams. While most biofilters rely on bacteria to degrade organic pollutants, biofilters utilizing a fungal biofilm have the potential to be an efficient and robust treatment alternative. In this study, two surfactants were evaluated for their ability to activate the spores of the fungus Exophiala lecanii-corni and reduce the start-up period typically observed in fungal vapor-phase bioreactors. Sodium dodecyl sulfate, an anionic surfactant, was found to inhibit growth of E. lecanii-corni. Polyoxyethylene sorbitan monolaurate (Tween 20), a nonionic surfactant, stimulated bud formation and enhanced toluene degradation in E. lecanii-corni cultures. Tween 20 was also found to enhance inoculum development by shortening the lag period during culture growth. However, when bioreactors were presoaked in medium containing Tween 20, washout of the fungal cells occurred during inoculation, inhibiting the initial fungal biofilm development. After a seven-day start-up period, no detrimental effects on reactor performance due to residual Tween 20 were observed, and toluene elimination capacities of up to 150?g/m3?h were achieved. 相似文献
70.
Nigg Joel T.; Blaskey Lisa G.; Stawicki Julie Ann; Sachek Jennifer 《Canadian Metallurgical Quarterly》2004,113(4):614
Neurogenetic models predict neuropsychological weaknesses in the relatives of children with attention-deficit/ hyperactivity disorder (ADHD). The authors examined executive and regulatory measures in 386 relatives (307 parents, 79 siblings) of children with ADHD combined type, ADHD inattentive type, and controls. Predicted deficits were seen on trailmaking (relatives of ADHD combined type only), stop-signal reaction times (relatives of girls only), and response variability (mothers only) but not on naming or output speed. Effects generally held, even with relatives' ADHD status controlled. A neuropsychologically impaired subgroup of children with ADHD had relatives with clear neuropsychological weaknesses. The authors conclude that a neurogenetic model of ADHD etiology is supportable only for a subset of executive functions and that neuropsychological heterogeneity warrants more examination in ADHD. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献