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21.
Banendu Sunder Dash Gils Jose Yu-Jen Lu Jyh-Ping Chen 《International journal of molecular sciences》2021,22(6)
Cancer is one of the deadliest diseases in human history with extremely poor prognosis. Although many traditional therapeutic modalities—such as surgery, chemotherapy, and radiation therapy—have proved to be successful in inhibiting the growth of tumor cells, their side effects may vastly limited the actual benefits and patient acceptance. In this context, a nanomedicine approach for cancer therapy using functionalized nanomaterial has been gaining ground recently. Considering the ability to carry various anticancer drugs and to act as a photothermal agent, the use of carbon-based nanomaterials for cancer therapy has advanced rapidly. Within those nanomaterials, reduced graphene oxide (rGO), a graphene family 2D carbon nanomaterial, emerged as a good candidate for cancer photothermal therapy due to its excellent photothermal conversion in the near infrared range, large specific surface area for drug loading, as well as functional groups for functionalization with molecules such as photosensitizers, siRNA, ligands, etc. By unique design, multifunctional nanosystems could be designed based on rGO, which are endowed with promising temperature/pH-dependent drug/gene delivery abilities for multimodal cancer therapy. This could be further augmented by additional advantages offered by functionalized rGO, such as high biocompatibility, targeted delivery, and enhanced photothermal effects. Herewith, we first provide an overview of the most effective reducing agents for rGO synthesis via chemical reduction. This was followed by in-depth review of application of functionalized rGO in different cancer treatment modalities such as chemotherapy, photothermal therapy and/or photodynamic therapy, gene therapy, chemotherapy/phototherapy, and photothermal/immunotherapy. 相似文献
22.
Ignacio Hernandez Laura Tesoro Rafael Ramirez-Carracedo Javier Diez-Mata Sandra Sanchez Marta Saura Jose Luis Zamorano Carlos Zaragoza Laura Botana 《International journal of molecular sciences》2021,22(6)
In response to cardiac ischemia/reperfusion, proteolysis mediated by extracellular matrix metalloproteinase inducer (EMMPRIN) and its secreted ligand cyclophilin-A (CyPA) significantly contributes to cardiac injury and necrosis. Here, we aimed to investigate if, in addition to the effect on the funny current (I(f)), Ivabradine may also play a role against cardiac necrosis by reducing EMMPRIN/CyPA-mediated cardiac inflammation. In a porcine model of cardiac ischemia/reperfusion (IR), we found that administration of 0.3 mg/kg Ivabradine significantly improved cardiac function and reduced cardiac necrosis by day 7 after IR, detecting a significant increase in cardiac CyPA in the necrotic compared to the risk areas, which was inversely correlated with the levels of circulating CyPA detected in plasma samples from the same subjects. In testing whether Ivabradine may regulate the levels of CyPA, no changes in tissue CyPA were found in healthy pigs treated with 0.3 mg/kg Ivabradine, but interestingly, when analyzing the complex EMMPRIN/CyPA, rather high glycosylated EMMPRIN, which is required for EMMPRIN-mediated matrix metalloproteinase (MMP) activation and increased CyPA bonding to low-glycosylated forms of EMMPRIN were detected by day 7 after IR in pigs treated with Ivabradine. To study the mechanism by which Ivabradine may prevent secretion of CyPA, we first found that Ivabradine was time-dependent in inhibiting co-localization of CyPA with the granule exocytosis marker vesicle-associated membrane protein 1 (VAMP1). However, Ivabradine had no effect on mRNA expression nor in the proteasome and lysosome degradation of CyPA. In conclusion, our results point toward CyPA, its ligand EMMPRIN, and the complex CyPA/EMMPRIN as important targets of Ivabradine in cardiac protection against IR. 相似文献
23.
24.
Aintzane Rueda-Martínez Aiara Garitazelaia Ariadna Cilleros-Portet Sergi Marí Rebeca Arauzo Jokin de Miguel Brbara P. Gonzlez-García Nora Fernandez-Jimenez Jose Ramon Bilbao Iraia García-Santisteban 《International journal of molecular sciences》2021,22(11)
Endometriosis is a common gynecological disorder that has been associated with endometrial, breast and epithelial ovarian cancers in epidemiological studies. Since complex diseases are a result of multiple environmental and genetic factors, we hypothesized that the biological mechanism underlying their comorbidity might be explained, at least in part, by shared genetics. To assess their potential genetic relationship, we performed a two-sample mendelian randomization (2SMR) analysis on results from public genome-wide association studies (GWAS). This analysis confirmed previously reported genetic pleiotropy between endometriosis and endometrial cancer. We present robust evidence supporting a causal genetic association between endometriosis and ovarian cancer, particularly with the clear cell and endometrioid subtypes. Our study also identified genetic variants that could explain those associations, opening the door to further functional experiments. Overall, this work demonstrates the value of genomic analyses to support epidemiological data, and to identify targets of relevance in multiple disorders. 相似文献
25.
Joo Batista A. Silva Regina C. M. de Paula Judith P. A. Feitosa Eduardo Diogo Gurgel‐Filho Claudio Maniglia‐Ferreira Francisco Jose de Souza Filho 《应用聚合物科学杂志》2006,100(5):4082-4088
Gutta‐percha cone is the most widely used material for root canal filling. The in vivo aging of this cone focus on the degradation of its main organic component, trans‐1,4‐polyisoprene, was studied. Aged cones (25 samples) from 2 to 30 years of root canal filling were extracted from different patients in the occasion of retreatment by mechanical way. The information about the aging time was given by the patients. Gel‐permeation chromatography (GPC) and infrared spectroscopy (FTIR) were the analytical techniques used. Polyisoprene degrades with time of aging, but in a slow process. Decrease in polymer molar mass from 5.7 × 105 to 1.7 × 105 g/mol was observed in polyisoprene from cone after 30 years of root canal filling and inside a noninfected tooth. In tooth with caries and periodontal infection, the decrease in molar mass is higher (4.6 × 104 g/mol in cone with 10 years of aging). The production of carbonyl and hydroxyl groups in the aged material indicates that the process is oxidative, even in closed teeth. In these cases, the oxygen could be provided from tissue fluid. The degradation mechanism is complex and depends on many factors, besides time of root canal filling. The dental problem caused by the aging could be the production and migration of cytotoxic substances to periodontal ligament and the reduction on the canal sealing property due to the polymer weight loss. Both of them could contribute to the root canal treatment failure. © 2006 Wiley Periodicals, Inc. J Appl Polym Sci 100:4082–4088, 2006 相似文献
26.
Jose Gerde Connie Hardy Walter Fehr Pamela J. White 《Journal of the American Oil Chemists' Society》2007,84(6):557-563
Two extruded-expelled physically refined soybean oils with reduced contents of linolenic acid, ultra-low- linolenic acid (ULL,
1.5%) and low-linolenic acid (LL, 2.6%), and a extruded-expelled physically refined control oil (control, 5.3% linolenic acid)
were evaluated by frying French fries in a commercial-like setting for 6 h day−1 during 23 days. The oils became darker, increased in yellow color at the beginning, and became redder and less green throughout
the process. Free fatty acids levels were not different among the oils until day 14, after which, ULL was different from the
control for the remainder of frying. The conjugated dienoic acid values were greatest in the control. Generally, ULL and LL
oils had lower percentages of polar compounds than did the control, providing a frying life 2 days longer than the control
and ~30% increase in frying time. A trained sensory panel evaluated the French fries on days 2, 5, and 6. Buttery and potato
flavors decreased, and rancid and painty flavors increased over frying time for all products. Rancid flavor was highest in
the fries from the control oil. Overall, the ULL and LL oils performed better than did the control oil and ULL tended to perform
better than the LL. 相似文献
27.
The humic acids, HA, extracted from a Spanish lignite and the nitrohumic acids, NHA, and nitrofulvic acids, NFA, extracted from the same lignite after its nitration, are hydrolysed with 6N HCI under reflux. The α-amino acids present in the hydrolysates are determined and thirteen α-amino acids are identified. The amounts of nitrogen in the amino-acids released by the hydrolysis increase according to the sequence: NFA > NHA > HA. 相似文献
28.
Dr. Christoph Goebel Prof.?Dr. Hans-Arno Jacobsen Victor del Razo Mag.? Christoph Doblander Dipl.-Ing. Jose Rivera Dipl-Inform.?Wirt Jens Ilg Dr. Christoph Flath Prof.?Dr. Hartmut Schmeck Prof.?Dr. Christof Weinhardt Dipl-Inform. Daniel Pathmaperuma Prof.?Dr. Dr.?h.?c. Hans-Jürgen Appelrath Prof.?Dr. Michael Sonnenschein Prof.?Dr. Sebastian Lehnhoff Prof.?Dr. Oliver Kramer Prof.?Dr. Thorsten Staake Prof.?Dr. Elgar Fleisch Prof.?Dr. Dirk Neumann Prof.?Dr. Jens Strüker Dr. Koray Erek Prof.?Dr. Rüdiger Zarnekow Dr. Holger Ziekow Prof.?Dr. J?rg L?ssig 《WIRTSCHAFTSINFORMATIK》2014,56(1):31-39
Due to the increasing importance of producing and consuming energy more sustainably, Energy Informatics (EI) has evolved into a thriving research area within the CS/IS community. The article attempts to characterize this young and highly dynamic field of research by describing current EI research topics and methods and provides an outlook of how the field might evolve in the future. It is shown that two general research questions have received the most attention so far and are likely to dominate the EI research agenda in the coming years: How to leverage information and communication technology (ICT) to (1) improve energy efficiency, and (2) to integrate decentralized renewable energy sources into the power grid. Selected EI streams are reviewed, highlighting how the respective research questions are broken down into specific research projects and how EI researchers have made contributions based on their individual academic background. 相似文献
29.
Jose Avalos 《个人电脑》2014,(11):94-95
正数字标牌的发展可以说是一场技术革命,它在不同的环境下有着不同的应用潜能。如今,凭借智能、互联、精准和可视性强等突出优势,数字标牌正已成为仅次于电视的第二大媒体形式,同时也是零售物联网的重要媒介,帮助实现真正的O2O业务模式。数字标牌,可能对很多人来说还是一个十分陌生的词汇,但它其实已在"不经意"间走入了你的生活:在商场里,装有人脸识别系统的数字标牌成为商家进行精准营销的"虚拟店铺";在街头,具有移动支付功能的自动售货机可提供多种便民服务;在学校内,安装了教学系统的电子白板可帮助师生实时 相似文献
30.
Jose Ygnacio Pastor Jaime Planas Manuel Elices 《Journal of the American Ceramic Society》1993,76(11):2927-2929
A new technique that provides stable fracture tests in brittle ceramic materials at room and at high temperature is presented. This technique uses the crack mouth opening displacement signal from a laser extensometer to feed the servo control of a hydraulic testing machine. In this way it is possible to obtain—in addition to the fracture toughness—the fracture energy and the R -curve, in a single test. 相似文献