With more than 25 million people affected, heart failure (HF) is a global threat. As energy production pathways are known to play a pivotal role in HF, we sought here to identify key metabolic changes in ischemic- and non-ischemic HF by using a multi-OMICS approach. Serum metabolites and mRNAseq and epigenetic DNA methylation profiles were analyzed from blood and left ventricular heart biopsy specimens of the same individuals. In total we collected serum from n = 82 patients with Dilated Cardiomyopathy (DCM) and n = 51 controls in the screening stage. We identified several metabolites involved in glycolysis and citric acid cycle to be elevated up to 5.7-fold in DCM (p = 1.7 × 10−6). Interestingly, cardiac mRNA and epigenetic changes of genes encoding rate-limiting enzymes of these pathways could also be found and validated in our second stage of metabolite assessment in n = 52 DCM, n = 39 ischemic HF and n = 57 controls. In conclusion, we identified a new set of metabolomic biomarkers for HF. We were able to identify underlying biological cascades that potentially represent suitable intervention targets. 相似文献
Silicon - In this study, a new magnetic ZrFe2O4@SiO2-TCPP nanocatalyst with high efficiency was used for the oxidation of cyclohexane to cyclohexanone (Ke) and cyclohexanol (Al). The mesoporous... 相似文献
Silicon - Magnesium calcium silicate nanostructures (MCSNS) loaded with (0.0, 0.6, 0.9, and 1.2 wt%) of Cephradine-drug consisting of mesoporous particles were functionally prepared by sol-gel... 相似文献
Today, the design of antenna arrays is very important in providing effective and efficient wireless communication. The purpose of antenna array synthesis is to obtain a radiation pattern with a low side lobe level (SLL) at a desired half power beam width in far-field. The amplitude and position values of the array elements can be optimized to obtain a radiation pattern with suppressed SLLs. In this paper, swarm-based metaheuristic algorithms including particle swarm optimization (PSO), artificial bee colony (ABC), mayfly algorithm (MA) and jellyfish search (JS) are compared to determine the optimal design of linear antenna arrays. Extensive experiments are conducted on designing 10-, 16-, 24- and 32-element linear arrays by determining the amplitude and positions. Experiments are repeated 30 times due to the random nature of swarm-based optimizers, and statistical results show that the performance of the novel algorithms, MA and JS, is better than that of the well-known PSO and ABC methods.
Nonalcoholic fatty liver disease (NAFLD) is strongly associated to the features of metabolic syndrome which can progress to cirrhosis, liver failure and hepatocellular carcinoma. However, the most common cause of mortality in people with NAFLD is not liver-related but stems from atherosclerotic cardiovascular disease (CVD). The prevalence of NAFLD is on the rise, mainly as a consequence of its close association with two major worldwide epidemics, obesity and type 2 diabetes (T2D). The exact pathogenesis of NAFLD and especially the mechanisms leading to disease progression and CVD have not been completely elucidated. Human fetuin-A (alpha-2-Heremans Schmid glycoprotein), a glycoprotein produced by the liver and abundantly secreted into the circulation appears to play a role in insulin resistance, metabolic syndrome and inflammation. This review discusses the links between NAFLD and CVD by specifically focusing on fetuin-A’s function in the pathogenesis of NAFLD and atherosclerotic CVD. 相似文献
The objective of this study is to identify defects such as surface cracks, subsurface defects and metal losses using feature based pulsed eddy current sensors. A new feature, termed as the rising point, related to the propagation time of electromagnetic waves in metallic targets is proposed for defect classification. Experimental studies of the validation, robustness of the new feature of rising time are reported. In addition to other features, defects can be detected and quantified robustly and lift-off can also be derived from the rising time. Conclusion and further work are derived on the basis of the findings. 相似文献
This paper reports on experimental results of aqueous heterophase polymerizations with monomers of quite different solubility in water ranging from the water-soluble 2-hydroxyethyl methacrylate to lauryl methacrylate with solubility in water of only about 10−4 mM. A calorimetric study revealed the strong influence of both the hydrophilicity of the monomer and the stirrer speed on the rate of polymerization in the absence of surfactants. In order to obtain maximum latex yield and high efficiency (which is a measure considering colloidal properties, polymerization recipe, and polymerization parameters) the initiator-surfactant combination must be properly chosen in dependence on the hydrophilicity of the monomer. Results are presented for sodium alkyl sulfates or disodium-N-stearoyl-l-glutamate as surfactant and potassium peroxodisulfate, or poly(ethylene glycol)-azo- compounds, or 2,2′-azobis(N-2′-methylpropanoyl-2-amino-alkyl-1)-sulfonates as initiators. 相似文献
Pre- and/or post-compensators are designed to square down a general MIMO system to a uniform rank system, the structure of which is almost similar to a SISO system. The method of squaring down either does not change the finite zero structure of the given MIMO system or simply adds additional finite zeros in the left half s-plane. The significance of such a squaring down lies in the simplicity of the structure of a uniform rank system lending itself for easy analysis and control design. 相似文献
The current work reports on the realization of movable micromachining devices using self-aligned single-mask fabrication process. Only dry etching process utilizing inductively coupled plasma reactive ion etching was used to release 3D micro structures from single crystal silicon substrate. No wet etching process is required to release the structures as is the case with silicon on insulator (SOI) wafers. Also the developed process does not require an SOI substrate and accordingly dispensing with the application of a wet etching step, thus yielding uniform structures without stiction. The optimized process was applied to realize thermally actuated microgrippers. The article presents the development of the fabrication process and demonstrates the operation of the fabricated device. The optimized process provides an avenue for low cost fabrication of movable micromachining devices without the use of complicated wet etching steps typically associated with SOI substrates. 相似文献