Molecular Mechanisms of Parthanatos and Its Role in Diverse Diseases

Differential evolution of apoptosis, programmed necrosis, and autophagy, parthanatos is a form of cell death mediated by poly(ADP-ribose) polymerase 1 (PARP1), which is caused by DNA damage. PARP1 hyper-activation stimulates apoptosis-inducing factor (AIF) nucleus translocation, and accelerates nicotinamide adenine dinucleotide (NAD⁺) and adenosine triphosphate (ATP) depletion, leading to DNA fragmentation. The mechanisms of parthanatos mainly include DNA damage, PARP1 hyper-activation, PAR accumulation, NAD⁺ and ATP depletion, and AIF nucleus translocation. Now, it is reported that parthanatos widely exists in different diseases (tumors, retinal diseases, neurological diseases, diabetes, renal diseases, cardiovascular diseases, ischemia-reperfusion injury...). Excessive or defective parthanatos contributes to pathological cell damage; therefore, parthanatos is critical in the therapy and prevention of many diseases. In this work, the hallmarks and molecular mechanisms of parthanatos and its related disorders are summarized. The questions raised by the recent findings are also presented. Further understanding of parthanatos will provide a new treatment option for associated conditions.     

Recursive identification for Hammerstein–Wiener systems with dead-zone input nonlinearity

A new recursive algorithm is proposed for the identification of a special form of Hammerstein–Wiener system with dead-zone nonlinearity input block. The direct motivation of this work is to implement on-line control strategies on this kind of system to produce adaptive control algorithms. With the parameterization model of the Hammerstein–Wiener system, a special form of model estimation error is defined; and then its approximate formula is given for the following derivation. Based on these, a recursive identification algorithm is established that aims at minimizing the sum of the squared parameter estimation errors. The conditions of uniform convergence are obtained from the property analysis of the proposed algorithm and an adaptive setting method for a weighted factor in the algorithm is given, which enhances the convergence of the proposed algorithm. This algorithm can also be used for the identification of the Hammerstein systems with dead-zone nonlinearity input block. Three simulation examples show the validity of this algorithm.     

一种基于重心法的连锁经营企业区域物流配送中心选址模型

提出了配送中心吸引力指数的概念,建立了以吸引力指数最大为目标函数的选址理论模型.考虑了模型解决具体问题的实用性,引入交通区位和地价2个权重因素对不同候选地址的吸引力指数进行加权,实现连锁经营企业区域物流配送中心的选址优化.通过具体算例表明算法能够获得更切合实际的目标解,且搜索时间短、效率较高.     

高压线路加装避雷器可减少线路雷击跳闸率

减少线路雷击跳闸率已成为人们共同关注的课题。国内外运行经验表明，加装线路避雷器可有效降低线路雷击跳闸率。浙江电力部门针对雷击跳闸频繁的线路，在易击段加装了线路型避雷器，积累了新的线路防雷经验。     

数—模综合仿真接口算法分析

针对微电网的推广应用还面临着诸多技术难题的问题,将电力系统数字仿真与物理模拟各自的优点与不足结合起来,充分发挥各自优势便可形成数模综合仿真模型,该模型将在微电网技术研究中发挥重大的作用。数模综合仿真接口是数模综合仿真系统的核心部件,而接口算法的选取是数模综合仿真接口设计的基础。在总结现有算法的基础上重点分析了理想变压器模型的稳定性,提出加强稳定性的有效措施及不稳定情况的处理方案。最后,通过算例仿真验证了各措施的有效性。     

同源连杆机构构成特性和传动角的研究

从理论上揭示了原始机构及其同源机构在尺寸型上的内在联系,即它们的确生成了同一条轨迹.还提出,同源机构与原始机构的对应构件有相同的角速度;在通常使用情况下,同源四杆机构与原始四杆机构具有相同的传动角.     

非均匀介质透射波Goos-Hnchen位移的研究

基于不变嵌入理论,推导出电磁波入射到非均匀介质平板,反射系数和透射系数的耦合波方程;利用稳态相位方法,分析了透射波Goos-Hnchen(GH)位移的性质。通过数值计算,研究了入射角和介质厚度对透射率及GH位移的影响。结果显示,介质厚度一定时,透射率在特定角度具有极大值,对应的透射波发生负的GH位移,并且位移绝对值最大;入射角不变时,透射率和GH位移随厚度呈周期性变化,厚度增加,透射率呈下降趋势,但GH位移呈增大趋势。GH位移受入射角和介质厚度的影响很大,因此,可以通过调节厚度和入射角,获得合适的透射率和GH位移。     

利用故障录波数据对负荷模型进行校核的探讨

介绍了故障录波装置的特点,结合内蒙古自治区负荷特点,探讨了利用故障录波数据对负荷模型进行校核的方法。利用萨拉齐处故障录波数据进行负荷模型校验,结果表明,仿真得到的功率曲线与故障录波数据得到的功率曲线吻合得很好,说明所建立的负荷模型是合理的。     

A vacuum ultraviolet laser with a submicrometer spot for spatially resolved photoemission spectroscopy

Vacuum ultraviolet(VUV)lasers have demonstrated great potential as the light source for various spectroscopies,which,if they can be focused into a small beam spot,will not only allow investigation of mesoscopic materials and structures but also find application in the manufacture of nano-objects with excellent precision.In this work,we report the construction of a 177 nm VUV laser that can achieve a record-small(〜0.76 μm)focal spot at a long focal length(~45 mm)by using a flat lens without spherical aberration.The size of the beam spot of this VUV laser was tested using a metal grating and exfoliated graphene flakes,and we demonstrated its application in a fluorescence spectroscopy study on pure and Tm3+-doped NaYF4 microcrystals,revealing a new emission band that cannot be observed in the traditional up-conversion process.In addition,this laser system would be an ideal light source for spatially and angleresolved photoemission spectroscopy.